Latest Ophthalmology research

Top 10 this week

Week of 20 September 2026

1. 1

   Safety and Efficacy of Brolucizumab in the Treatment of Patients with Diabetic Macular Edema and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

   Journal of clinical medicine · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 23 August 2026

   Brolucizumab meta‑analysis for DME and DR

2. 2

   Gas Versus Air Tamponade in Surgery for Full-Thickness Macular Hole: A Systematic Review and Meta-analysis

   Ophthalmology. Retina · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 18 September 2026

   Systematic review, gas vs air tamponade outcomes

3. 3

   Effect of Intracameral Air Injection on Corneal Endothelial Cell Loss After Phacoemulsification for Cataracts of LOCS III Nuclear Grade 4 or Higher: A Randomised Clinical Trial

   Clinical & experimental ophthalmology · Q1 journal · RCT · Evidence level 1 (High) · 14 September 2026

   Intracameral air reduces endothelial cell loss after phacoemulsification

4. 4

   Longitudinal Prediction of Retinal Sensitivity Based on Disease Progression Quantified From Optical Coherence Tomography in Geographic Atrophy

   Investigative ophthalmology & visual science · Q1 journal · RCT · Evidence level 1 (High) · 1 September 2026

   In a longitudinal analysis of 406 patients with geographic atrophy, each micrometer reduction in OCT-measured ellipsoid zone thickness was linked to a 0.1 decibel decline in microperimetry sensitivity, while thicker baseline zones correlated with better function (0.3 dB per µm). The study shows automated OCT metrics can forecast functional loss, but validation in larger cohorts is needed.

5. 5

   Effect of a mobile application-based whole-course nutrition management intervention in patients with age-related macular degeneration: a randomized controlled trial

   Frontiers in public health · Q1 journal · RCT · Evidence level 1 (High) · 3 September 2026

   App‑based nutrition improves AMD nutrient intake and QoL

6. 6

   COSMYC: a Core Outcome Set for MYopia clinical trials with Children and young people

   The British journal of ophthalmology · Q1 journal · RCT · Evidence level 1 (High) · 18 September 2026

   A three-phase COMET consensus process involving children, parents, eye-care professionals and researchers identified ten essential outcomes-such as axial length, visual acuity, eye health and quality of life-for myopia trials in youth. The study also produced stakeholder-endorsed recommendations for how each outcome should be measured, aiming to standardize future research and improve comparability.

7. 7

   Relationship of Neighborhood Socioeconomic Deprivation with Glaucoma Severity and Medication Adherence in Veterans

   Journal of glaucoma · Q1 journal · RCT · Evidence level 1 (High) · 7 September 2026

   Neighborhood deprivation not linked to glaucoma severity or adherence

8. 8

   Mucoadhesive recombinant human catalase for dry eye disease: From protein engineering to first-in-human study

   Med (New York, N.Y.) · Q1 journal · RCT · Evidence level 1 (High) · 18 September 2026

   High-quality evidence in a top journal

9. 9

   Temporal Variations in Inflammatory-Related Ocular Surface Parameters: A Systematic Review and Meta-Analysis

   Investigative ophthalmology & visual science · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 1 September 2026

   Very low certainty evidence on ocular surface inflammation timing

10. 10

    Efficacy and Effectiveness of the Recombinant Zoster Vaccine Against Herpes Zoster, Herpes Zoster Ophthalmicus, Postherpetic Neuralgia and Dementia: A Systematic Review and Meta-Analysis

    Reviews in medical virology · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 1 September 2026

    RZV provides very high protection against herpes zoster ophthalmicus

Paper of the day, last two weeks

• Long-Term Safety and Effectiveness of STREAMLINE Canaloplasty with Phacoemulsification in a Hispanic Population with Open-Angle Glaucoma

  Clinical ophthalmology (Auckland, N.Z.) · Q1 journal · Non-randomized trial · Evidence level 2 (Moderate) · 14 September 2026

  STREAMLINE canaloplasty long‑term outcomes

• Retrospective single-center study of endogenous endophthalmitis, Northeastern China, 2010-2023

  Frontiers in cellular and infection microbiology · Q1 journal · Unclassified · Evidence level 5 (Expert Opinion) · 3 September 2026

  Intravitreal injection reduces risk of poor visual prognosis

• Outcomes of As-Needed Aflibercept Treatment After Complete Regression in Polypoidal Choroidal Vasculopathy

  JAMA ophthalmology · Q1 journal · Prospective cohort · Evidence level 2 (Moderate) · 17 September 2026

  In a prospective Thai cohort, 32 of 81 eyes achieved complete polypoidal regression, and after switching to PRN aflibercept, about 50% remained fluid-free for two years while the other half redeveloped exudation. Recurrences were linked to baseline OCT features, suggesting imaging biomarkers could guide which patients need continued therapy.

• Intraocular Pressure-Lowering Effect of Netarsudil Across Glaucoma Severity

  Journal of glaucoma · Q1 journal · Cohort · Evidence level 3 (Low) · 28 August 2026

  Netarsudil IOP lowering across glaucoma severity stages

• Comparison of current treatment strategies for AMD-related submacular haemorrhage: Real-world outcomes

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · Q1 journal · Cohort · Evidence level 4 (Very Low) · 12 September 2026

  Real‑world outcomes of AMD submacular haemorrhage treatments

• Visual performance of a refractive extended depth of field intraocular lens in monovision and emmetropic settings

  American journal of ophthalmology · Q1 journal · Unclassified · Evidence level 5 (Expert Opinion) · 12 September 2026

  EDF IOL visual performance trial

• Autonomous AI-driven point-of-care screening for diabetic retinopathy compared to reading center multi-expert clinical review: results from three prospective controlled pivotal validation studies with AEYE-DS in over 1,200 patients

  Frontiers in digital health · Q1 journal · Review / opinion · Evidence level 5 (Expert Opinion) · 25 August 2026

  In three prospective studies of over 1,200 patients, the autonomous AEYE-DS algorithm identified more-than-mild diabetic retinopathy with about 93% sensitivity and 91-94% specificity compared with multi-expert reading-center grading. Imageability exceeded 99% and reproducibility was high across handheld and desktop cameras, suggesting the tool could expand point-of-care screening access.

• Faricimab in previously treated nAMD: Real-World Outcomes of a No-Loading-Dose Switching Protocol

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · Q1 journal · Retrospective cohort · Evidence level 4 (Very Low) · 10 September 2026

  Real‑world faricimab switch protocol in nAMD, interval extension

• Efficacy of conbercept pro re nata (PRN) versus treat-and-extend (T&E) regimens following five initial monthly doses in diabetic macular edema: a 24-month retrospective cohort study

  Frontiers in endocrinology · Q1 journal · Retrospective cohort · Evidence level 3 (Low) · 26 August 2026

  PRN vs T&E conbercept regimens in DME

• Intereye Correlation in Bilateral Geographic Atrophy: Morphology and Growth Rates in the Age-Related Eye Disease Study

  Ophthalmology science · Q1 journal · RCT · Evidence level 1 (High) · 4 August 2026

  Inter‑eye GA morphology and growth analysis

• Reticular Pseudodrusen Subtypes and Their Interaction With Soft Drusen: Longitudinal Structure-Function Analysis

  American journal of ophthalmology · Q1 journal · Retrospective cohort · Evidence level 3 (Low) · 7 September 2026

  RPD subtypes impact retinal sensitivity in AMD

• ELIOS Excimer Laser Trabeculostomy with Phacoemulsification in Primary Open-Angle Glaucoma: 24-Month Outcomes of Pivotal Trial

  Ophthalmology. Glaucoma · Q1 journal · Non-randomized trial · Evidence level 2 (Moderate) · 8 September 2026

  In a multicenter trial of 318 eyes, excimer laser trabeculostomy performed at the time of cataract surgery lowered unmedicated intraocular pressure by about 8 mm Hg, with 76% of patients maintaining at least a 20% drop at 24 months and 82% off glaucoma drops. The procedure showed no intra-operative complications and a safety profile similar to cataract surgery alone, suggesting it as a viable MIGS option for mild-to-moderate POAG.

Evidence summaries in Ophthalmology

• Glaucoma
• Primary Open-Angle Glaucoma
• Age-Related Macular Degeneration
• Diabetic Retinopathy