Short- and Long-Term Control of Hypertension After Bariatric Surgery: A 10-Year Prospective Study
In brief
Bariatric surgery patients had 71% blood pressure control at 10 years
In a prospective study of 248 Chinese patients with obesity and hypertension, blood pressure fell soon after bariatric surgery and remained about 15 mmHg lower systolic at follow-up; 70.8% of those assessed at 10 years had blood pressure below 140/90 mmHg. Long-term results came from smaller subsets, so durability across the full cohort remains uncertain.
- Journal
- MedComm (Q1)
- Published
- 29 October 2026
- Study design
- Prospective / inception cohort
- Evidence level
- Level 4, Very Low (CEBM 4)
- Authors
- Xiaoxiao Zhong, Yaoquan Cao, Xulong Sun, Pengzhou Li, Weizheng Li, Hong Yuan, et al.
- PMID
- 42959411
- DOI
- 10.1002/mco2.71097
Why clinicians should know about it
- Picked for Bariatric and Metabolic Surgery (paper of the day, 1 November 2026): Ten-year prospective evidence on hypertension control after bariatric surgery
Abstract
Current guidelines support bariatric surgery (BS) as an effective treatment mainly for patients with severe obesity and poorly controlled hypertension. However, evidence in non-severely obese Asian populations remains limited. This multicenter prospective cohort study included 248 Chinese patients with obesity and hypertension who underwent BS between 2010 and 2019 and were followed for up to 10 years. An exploratory mechanistic substudy (n = 14) evaluated 24-h ambulatory blood pressure (BP), various biomarkers, and urinary electrolytes before and after BS. Compared with baseline, adjusted mean systolic blood pressure (SBP) was lower by 16.4, 14.8, 15.1, 18.0, and 15.2 mmHg, while diastolic blood pressure (DBP) decreased by 11.4, 9.1, 9.9, 10.5, and 11.4 mmHg at 3 months, 6 months, and 1, 5, 10 years postoperatively. During postoperative Days 1 to 7 (POD1-7), mean SBP and DBP dropped by 8.6 and 10.4 mmHg, and the proportion achieving BP < 140/90 mmHg increased to 62.9% and remained at 70.8% even 10 years later. The substudy has observed that early BP reduction was accompanied by increased electrolytes and water excretion, as well as a transient suppression of renin-angiotensin-aldosterone system (RAAS)-related biomarkers, providing a direction for future in-depth exploration. These findings suggest that BS in Chinese patients was followed by rapid BP reductions, with lower BP observed among the smaller subsets assessed longer term, including those without severe obesity. Trial Registration: NCT07183137.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.