Surgical management of intraocular lens dislocation in highly myopic eyes
In brief
Tailored surgery improved vision in 28 highly myopic eyes with IOL dislocation
In this single-center retrospective study, vision improved six months after surgery tailored to the eye's capsular support; among 18 eyes retaining an intraocular lens, most stayed within the study's thresholds for tilt and decentration. Corneal endothelial cell counts fell by about 12%, though no corneal decompensation occurred. The small study cannot establish which approach works best, and retinal blood-flow findings were inconsistent.
- Journal
- Frontiers in medicine (Q1)
- Published
- 5 October 2026
- Study design
- Unclassified
- Evidence level
- Level 5, Expert Opinion (CEBM 5)
- Authors
- Shiyu Tang, Chenxi Li, Zihan Xie, Fan Yang, Yuye Zhang, Wenting Cai, et al.
- PMID
- 42898689
- DOI
- 10.3389/fmed.2026.1922084
Why clinicians should know about it
- Picked for Ophthalmology (paper of the day, 24 October 2026): Evaluates visual outcomes and safety after IOL dislocation surgery
Abstract
OBJECTIVE: To evaluate the postoperative visual function, intraocular lens (IOL) positional stability and ocular safety of surgical strategies tailored to capsular support status for the treatment of IOL dislocation in patients with high myopia, and to explore the potential impact of such complex surgeries on macular microcirculation. METHODS: This single-center retrospective included 28 patients (28 eyes) with high myopia and IOL dislocation who underwent surgical treatment from January 2024 to August 2025. Surgical approaches were selected based on preoperative anatomical conditions and capsular status, including IOL explantation without secondary IOL implantation in 10 eyes, in-the-bag IOL repositioning in 6 eyes, and sutured scleral fixation of a posterior chamber IOL in 12 eyes. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and IOL tilt and decentration before surgery and at 6 months postoperatively. Safety measures included intraocular pressure (IOP), corneal endothelial cell density (ECD), postoperative complications. Postoperative retinal microcirculation parameters assessed by WF-OCTA were included as exploratory outcomes. Whereas the IOL-position comparison included only the 18 operated eyes retaining an IOL and their corresponding 18 matched control eyes. Before quantitative analysis, all OCTA images were reviewed for image quality. RESULTS: Compared with preoperative values, UDVA (0.59 ± 0.46 logMAR, P = 0.005) and CDVA (0.38 ± 0.59 logMAR, P = 0.031) were significantly improved at 6 months postoperatively. Postoperative IOL position was evaluated in the 18 eyes retaining an IOL; 3 (16.7%) exceeded the 6° tilt threshold and 2 (11.1%) exceeded the 0.6 mm decentration threshold. The postoperative 2D tilt of IOL was 4.51 ± 2.17°, 2D decentration was 0.45 ± 0.33 mm, 3D tilt was 4.41 ± 2.09°, and 3D decentration was 0.44 ± 0.34 mm. Corneal ECD decreased from 2672.72 ± 312.26 cells/mm2 preoperatively to 2356.61 ± 420.15 cells/mm2 postoperatively (P < 0.001), yet no corneal decompensation occurred. IOP remained stable during the follow-up period, and the incidence of complications was low. Regional WF-OCTA parameters varied between the operated and matched control eyes, without a consistent pattern across macular regions. CONCLUSION: In patients with high myopia and IOL dislocation, different surgical approaches can achieve stable intraocular optical reconstruction and improve mid-to-long-term visual function under the corresponding anatomical conditions. Although the magnitude of visual acuity improvement is limited in this population due to high myopia- related high-risk fundus factors.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.