Latest Obstetrics and Gynecology research

Top 10 this week

Week of 20 September 2026

1. 1

   Association Between Proteinuria and Pregnancy Outcomes in Women With Preterm Pre-Eclampsia Undergoing Expectant Management: Secondary Analysis of Two Randomised Trials

   BJOG : an international journal of obstetrics and gynaecology · Q1 journal · RCT · Evidence level 1 (High) · 18 September 2026

   Proteinuria levels predict latency and maternal outcomes in pre‑eclampsia

2. 2

   Risk factors for wound complications after second-degree tears or episiotomy - a secondary analysis of the REPAIR study

   American journal of obstetrics and gynecology · Q1 journal · RCT · Evidence level 1 (High) · 14 September 2026

   Prophylactic antibiotics reduced wound complications

3. 3

   Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trial

   Annals of medicine · Q1 journal · RCT · Evidence level 1 (High) · 16 September 2026

   Double‑blind RCT of opioid‑free analgesia after gyn laparoscopy

4. 4

   Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial

   JAMA · Q1 journal · RCT · Evidence level 1 (High) · 17 September 2026

   In a double-blind trial of 370 nulliparous women, a 10 mL intrauterine dose of mepivacaine lowered average pain scores from 59 mm to 44 mm during IUD insertion, and 98% reported tolerable pain versus 91% with saline. The modest but statistically solid benefit suggests a simple option to improve comfort, though its impact on overall IUD uptake remains to be seen.

5. 5

   Combined pelvic floor training and hormonal therapy for endometriosis pain recurrence: a propensity score-matched study

   Frontiers in medicine · Q1 journal · RCT · Evidence level 1 (High) · 31 August 2026

   Pelvic floor training plus hormonal therapy for endometriosis

6. 6

   Identifying systemic vulnerability phenotypes associated with programmed regimens in frozen embryo transfer: a secondary analysis of a multicentre randomized clinical trial

   Frontiers in medicine · Q1 journal · RCT · Evidence level 1 (High) · 3 September 2026

   Secondary analysis of RCT on FET regimens and pre‑eclampsia

7. 7

   Effect of homeopathy on symptom severity and quality of life among menopausal women: A meta-analysis

   International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 18 September 2026

   Meta‑analysis of homeopathy for menopause, not obstetric focus

8. 8

   Comparison of the effects of two sexual counseling models, GES (Good Enough Sex) and PLISSIT (Permission, Limited Information, Specific Suggestions, Intensive Therapy), on sexual dysfunction in postmenopausal women: a randomized controlled trial

   Menopause (New York, N.Y.) · Q1 journal · RCT · Evidence level 1 (High) · 15 September 2026

   Sexual counseling RCT in postmenopausal women

9. 9

   Effects of Withania somnifera root extract on sleep quality, body composition, and menopausal symptoms in postmenopausal women: a randomized, double-blind, placebo-controlled trial

   Menopause (New York, N.Y.) · Q1 journal · RCT · Evidence level 1 (High) · 15 September 2026

   Ashwagandha trial in postmenopausal women

10. 10

    Clinical outcomes of selective dorsal cryoneurolysis in patients with lifelong premature ejaculation: a retrospective cohort of 108 men

    The journal of sexual medicine · Q1 journal · RCT · Evidence level 1 (High) · 14 September 2026

    In a retrospective series of 108 men with lifelong premature ejaculation, median intravaginal ejaculatory latency time rose from 54 seconds to 231 seconds and stayed elevated through 12 months, while patient-reported scores improved and no erectile dysfunction occurred. About one in ten men did not achieve a meaningful response, and the procedure's long-term comparative efficacy remains unproven.

Paper of the day, last two weeks

• Incidence of pre-eclampsia in triplet pregnancies with and without embryo reduction

  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · Q1 journal · Retrospective cohort · Evidence level 3 (Low) · 19 September 2026

  In a multicenter review of 1,020 triplet gestations, 9.9% of non-reduced trips developed pre-eclampsia before 37 weeks and 7.2% before 34 weeks, representing a 21-times greater risk than singletons and eight-times greater than twins. Reducing triplets to a singleton lowered the risk to that of singletons, suggesting embryo reduction may mitigate early pre-eclampsia, but prospective data are needed.

• Antihypertensive Treatment Escalation and Maternal Outcomes During Expectant Management of Early-Onset Preeclampsia With Severe Features

  American journal of obstetrics and gynecology · Q1 journal · Retrospective cohort · Evidence level 3 (Low) · 18 September 2026

  Antihypertensive escalation linked to early‑onset preeclampsia outcomes

• Development and Validation of a Prenatal Doppler Hemodynamic-Clinical Risk Model for Predicting Adverse Perinatal Outcomes in Fetuses with Umbilical Artery Thrombosis

  Journal of clinical medicine · Q1 journal · Cohort · Evidence level 3 (Low) · 1 September 2026

  Multivariable model predicts adverse perinatal outcomes in UAT

• Syndecan-1 polymorphisms are associated with preeclampsia

  Placenta · Q1 journal · Case-control · Evidence level 3 (Low) · 11 September 2026

  In a case-control study of 130 women with preeclampsia and 1,300 normotensive pregnancies, carriers of the SDC1 rs2230924 C/T genotype or T allele had roughly 1.6 times higher odds of developing the disorder, and a specific haplotype doubled the risk. Affected women also showed lower circulating and placental SDC1 levels, suggesting a mechanistic link, but larger multi-ethnic studies are needed before testing this marker clinically.

• Development and internal validation of an intrapartum caesarean risk prediction model to guide rural obstetric transfer decisions: a population-based study using BORN Ontario data

  BMJ open · Q1 journal · Retrospective cohort · Evidence level 3 (Low) · 11 September 2026

  Prediction model for emergency caesarean delivery

• Aspirin prophylaxis for superimposed preeclampsia in women with chronic hypertension: a retrospective cohort study

  Pregnancy hypertension · Q1 journal · Prospective cohort · Evidence level 2 (Moderate) · 12 September 2026

  In a Chinese cohort of 504 pregnancies with chronic hypertension, women who started low-dose aspirin between 8 and 20 weeks had roughly an 80% lower odds of developing superimposed preeclampsia, and a 90% lower odds of early-onset disease. The drug also lowered rates of preterm birth and serious neonatal complications without raising bleeding risk, though the optimal dose needs prospective testing.

• Predictors of Shoulder Dystocia: A Retrospective Case-Control Study

  Birth (Berkeley, Calif.) · Q1 journal · Cohort · Evidence level 3 (Low) · 10 September 2026

  Fetal macrosomia predicts shoulder dystocia

• Trends of induction of labor with success rates: Experience of a tertiary care center

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · Q1 journal · Prospective cohort · Evidence level 2 (Moderate) · 10 September 2026

  Success rates and predictors of prostaglandin E2 induction of labor

• Posttraumatic stress disorder 2 months after induced vaginal delivery: A multicenter prospective study

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · Q1 journal · RCT · Evidence level 1 (High) · 11 September 2026

  Post‑traumatic stress after induced vaginal delivery

• Pharmacological pain relief and postpartum bleeding in women with moderate or severe anemia: A cohort analysis of the WOMAN-2 trial

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · Q1 journal · Unclassified · Evidence level 5 (Expert Opinion) · 7 September 2026

  Pharmacological pain relief and postpartum bleeding in women with moderate

• Connecting Risk Prediction to Intervention: Evidence from a Randomized Trial Testing Patient Navigation and Education to Improve Postpartum Outcomes

  American journal of obstetrics & gynecology MFM · Q1 journal · RCT · Evidence level 1 (High) · 7 September 2026

  Connecting Risk Prediction to Intervention: Evidence from a Randomized Trial

• Molecular groups predict response to fertility-sparing treatment of endometrial carcinoma: a systematic review and metanalysis

  Gynecologic oncology · Q1 journal · SR of cohorts · Evidence level 4 (Very Low) · 4 September 2026

  Molecular groups predict fertility‑sparing EC response

Evidence summaries in Obstetrics and Gynecology

• Endometriosis
• Preeclampsia
• Cervical Cancer
• Ectopic Pregnancy