Association between Trust and Patient-Reported Outcomes and Experience in Prostate Cancer Patients
In brief
Higher trust linked to 80% higher odds of active prostate cancer treatment
In a secondary analysis of a multicenter trial, men with localized prostate cancer who reported higher trust in their physician had 80% higher odds of choosing surgery or radiation over active surveillance. Higher trust also tracked with better physical and mental quality of life and greater satisfaction through 24 months, but the analysis shows association, not that trust caused these differences.
- Journal
- Medical decision making : an international journal of the Society for Medical Decision Making (Q1)
- Published
- 15 October 2026
- Study design
- Randomized controlled trial
- Evidence level
- Level 1, High (CEBM 1b)
- Authors
- Sumedha Chhatre, Joseph J Gallo, Thomas Guzzo, Knashawn H Morales, Neha Vapiwala, S Bruce Malkowicz, et al.
- PMID
- 42878269
- DOI
- 10.1177/0272989X261493550
Why clinicians should know about it
- Picked for Urology (top studies of the week, 18 October 2026): Higher trust linked to active treatment choice
Abstract
PURPOSE: To evaluate the association between patient-physician trust, treatment choice, patient-reported outcomes, and patient-reported experiences among patients with localized prostate cancer. MATERIALS AND METHODS: We conducted a secondary analysis of data from a multicenter randomized controlled trial among patients with localized prostate cancer. Trust was measured at baseline, prior to treatment, using the Patient Trust-Wake Forest Physician Trust Scale (PTWF). Outcomes were assessed at baseline and at 3, 6, 12, and 24 mo. Treatments were robotic-assisted laparoscopic radical prostatectomy, radiation therapy, and active surveillance. The primary treatment outcome was receipt of active treatment (surgery or radiation therapy) versus active surveillance. Multivariable logistic regression and linear mixed-effects models were adjusted for age, race/ethnicity, marital status, education, employment, insurance, prostate cancer risk group, intervention assignment, and study site. Sensitivity analyses modeling trust as a continuous variable yielded findings that were materially consistent with the primary analyses. RESULTS: The high-trust group had higher odds of receiving active treatment than the low-trust group did (adjusted odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.14-2.87; P = 0.013). Higher baseline trust was also consistently associated with better physical and mental health-related quality of life and higher satisfaction with care and treatment decision making across follow-up assessments through 24 mo. Sensitivity analyses using trust as a continuous measure produced similar findings. CONCLUSIONS: Higher patient-physician trust was independently associated with treatment choice, patient-reported outcomes, and patient-reported experience. These findings underscore the importance of patient-physician trust as a component of patient-centered cancer care and shared decision making. Future studies should evaluate interventions designed to strengthen trust and improve patient-centered outcomes across diverse clinical settings.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.