Predicting risk of infection in infants with gastroschisis
- Journal
- Journal of perinatology : official journal of the California Perinatal Association (Q1)
- Published
- 21 September 2026
- Study design
- Cohort / observational study
- Evidence level
- Level 3, Low (CEBM 3b)
- Authors
- Stefanie Riddle, Isabella Zaniletti, Karna Murthy, Alaina Pyle, Ellen Bendel-Stenzel, Elizabeth Jacobson, et al.
- PMID
- 42768138
- DOI
- 10.1038/s41372-026-02880-x
Why clinicians should know about it
- Picked for Pediatric Surgery (paper of the day, 23 September 2026): Predictors of BSI and UTI in gastroschisis infants
Abstract
OBJECTIVE: Identify clinical predictors of bloodstream (BSI) and urinary tract infections (UTI) in infants with gastroschisis. STUDY DESIGN: Retrospective analysis of infants with gastroschisis admitted to 47 neonatal intensive care units (NICUs) contributing to the Children's Hospitals Neonatal Database (CHND) from 2010-23. Outcomes were occurrence of BSI or UTI before discharge. Generalized linear models with generalized estimating equation (GEE) to account for hospitals as clusters utilized to identify factors independently related to the outcomes. RESULT: Of 3987 eligible infants, rates of early BSI (within 3 days of birth) were 0.4%, any BSI 7.6% and UTI 3.5%. Median age of infection was 32 days for BSI and 39 days for UTI. Bowel atresia, silo/staged closure, patch closure, and additional anomalies were independently associated with these infections. CONCLUSION: We identified clinical predictors of BSI and UTI, which should facilitate limitation of antibiotic use in low risk patients.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.