Syndecan-1 polymorphisms are associated with preeclampsia
In brief
SDC1 rs2230924 C/T genotype raises preeclampsia risk by about 60%
In a case-control study of 130 women with preeclampsia and 1,300 normotensive pregnancies, carriers of the SDC1 rs2230924 C/T genotype or T allele had roughly 1.6 times higher odds of developing the disorder, and a specific haplotype doubled the risk. Affected women also showed lower circulating and placental SDC1 levels, suggesting a mechanistic link, but larger multi-ethnic studies are needed before testing this marker clinically.
- Journal
- Placenta (Q1)
- Published
- 11 September 2026
- Study design
- Case-control study
- Evidence level
- Level 3, Low (CEBM 3b)
- Authors
- Tzu-Yang Chang, Yi-Yung Chen, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen
- PMID
- 42748810
- DOI
- 10.1016/j.placenta.2026.09.004
Why clinicians should know about it
- Picked for Obstetrics and Gynecology (paper of the day, 18 September 2026): Case‑control study of SDC1 polymorphisms and preeclampsia
Abstract
OBJECTIVES: Preeclampsia (PE), a major obstetrical challenge, involves intricate inflammatory and oxidative stress pathways. In this study, we investigated the genetic association between the syndecan-1 (SDC1) gene, a key regulator in these mechanisms, and PE risk. METHODS: A hospital-based case-control study including 130 pregnant women with PE and 1300 healthy pregnant women (controls) was conducted. SDC1 rs2230924 C/T and rs1131351 C/G polymorphisms were genotyped. Plasma SDC1 and placental SDC1 expression levels were measured using ELISA and Western blotting. RESULTS: We identified that the SDC1 rs2230924 C/T genotype and the T allele were associated with an increased risk of PE (odds ratios: 1.65 and 1.61; P = 0.02 and 0.01; Pc = 0.04 and 0.02). Moreover, the rs2230924 T-rs1131351 C haplotype significantly increases the risk of developing PE (odds ratio: 2.12, P = 0.007, Pc = 0.03). PE women had lower plasma SDC1 levels than controls (P = 0.032). Plasma SDC1 levels were lower in controls with the rs2230924 C/T and T/T genotypes than in those with the C/C genotype (P = 0.002 and P = 0.025). A significant reduction of SDC1 protein expression was also observed in placentae from PE cases (P = 0.03). DISCUSSION: The SDC1 rs2230924 C/T genotype and T allele may increase PE risk in pregnant women. Validation in larger and multi-ethnic cohorts is necessary before clinical application.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.