Continuous clinical and radiological follow-up of isainlay reverse shoulder prostheses: results from the isa registry with a minimum of 1-year follow-up
In brief
Inlay reverse shoulder prosthesis lifts Constant score from 28 to 72 over five years
In a registry of 856 patients, the isainlay inlay-stem reverse shoulder implant raised the Constant-Murley functional score from a pre-operative average of 28 points to 72 points at five-year follow-up, with consistent pain relief and functional gains across all measured scores. Radiographs showed very few cases of osteolysis and none involving all stem zones, suggesting durable mid-term performance comparable to other reverse designs.
- Journal
- Journal of shoulder and elbow arthroplasty (Q1)
- Published
- 26 June 2026
- Study design
- Retrospective cohort
- Evidence level
- Level 3, Low (CEBM 3b)
- Authors
- Lauriane C Flores, Flore A Bordes, Virginie E Guinet
- PMID
- 42571468
- DOI
- 10.1016/j.jsea.2026.100056
Why clinicians should know about it
- Picked for Orthopedics and Sports Medicine (paper of the day, 10 August 2026): Mid‑term outcomes of inlay reverse shoulder prosthesis
Abstract
BACKGROUND: Reverse total shoulder arthroplasty (rTSA) has been the subject of numerous studies reporting promising clinical outcomes which has led to its widespread use as the most common implant in shoulder arthroplasty today. However, few mid-term studies have reported outcomes of newer stem designs. This study evaluates the clinical and radiographic outcomes of a reverse shoulder prosthesis with an inlay stem design, through a multicenter, retrospective cohort analysis. METHODS: This retrospective study included 856 patients who underwent primary implantation of the isainlay, a reverse total shoulder prosthesis with an inlay stem design, between March 2019 and October 2024. Data were collected at pre-operative and post-operative time points (1 year, 3 years, and 5 years). The clinical outcomes were assessed using: Constant-Murley Score, American Shoulder and Elbow Surgeons score, Simple Shoulder Test, Subjective Shoulder Value, and visual analog scale for pain. Radiological assessments, including the presence of osteolysis around the humeral stems of the prostheses, were also performed at the key follow-up visits. RESULTS: At each follow-up, patients implanted with the isainlay stem design prosthesis demonstrated significant improvements in both pain and shoulder function (P < .0001) across all evaluated clinical scores. The primary outcome measure, the Constant-Murley Score, improved from 28 pre-operatively to 72 at 5 years. Radiographic analysis showed a low incidence of osteolysis, with no cases involving all stem zones. CONCLUSION: Over the 5-year results, this reverse prosthesis design demonstrated favorable clinical and radiographic outcomes, comparable to those of other rTSA implants.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.