CONNECT4 APOE: A randomized trial of telephone versus real-time two-way videoconference for disclosure of APOE genotype results in cognitively unimpaired adults
- Journal
- Alzheimer's & dementia : the journal of the Alzheimer's Association (Q1)
- Published
- 1 July 2026
- Study design
- Randomized controlled trial
- Evidence level
- Level 1, High (CEBM 1b)
- Authors
- Elisabeth McCarty Wood, Jessica B Langbaum, Brian L Egleston, Demetrios Ofidis, Cara Cacioppo, Carolyn M Langlois, et al.
- PMID
- 42509665
- DOI
- 10.1002/alz.71658
Why clinicians should know about it
- Picked for Geriatrics and Gerontology (paper of the day, 29 July 2026).
- Picked for Psychiatry and Mental Health (paper of the day, 29 July 2026).
Abstract
INTRODUCTION: Data are needed to inform best practices for disclosing apolipoprotein E (APOE) results given increasing indications for testing. METHODS: CONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60-75 years of age. Outcomes were collected at baseline, 2-7 days, 6 weeks, and 6 months. RESULTS: A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70-75 year), whereas teleconference reduced depressive symptoms more for younger participants (60-64 years) and videoconference increased knowledge for non-White participants as compared to White participants. DISCUSSION: These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.
Abstract as published, via PubMed.
For healthcare professionals. The summary is generated by AI from the published abstract, and the evidence level is assigned automatically from the study design on the Oxford CEBM hierarchy. Neither is medical advice. Read the full paper before changing practice.