Dietary Supplements and Oxidative Stress Management in Young Adults Following Intensive Exercise: A Systematic Review

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Abstract

Strenuous exercise is a well-established physiological stimulus that enhances muscular strength and hypertrophy but can also increase reactive oxygen species production, leading to oxidative stress (OS). Numerous studies have investigated whether dietary supplements can attenuate exercise-induced OS, yet findings remain inconsistent, and methodological quality varies. This systematic review aimed to synthesize current clinical evidence on dietary supplementation for OS management in young adults undergoing intensive exercise and to evaluate study methodology critically. The review was conducted in accordance with PRISMA 2021 guidelines and the Cochrane Risk of Bias (RoB 2.0) framework and was prospectively registered in PROSPERO. A comprehensive search of MEDLINE (PubMed), Scopus, Cochrane Central, ClinicalTrials.gov, OpenGrey, and ISRCTN identified interventional and observational human studies assessing supplementation and OS biomarkers. Forty-six studies met the inclusion criteria. The analysis revealed substantial heterogeneity in study design and reporting quality. Frequent methodological limitations included incomplete reporting of allocation concealment, participant and investigator blinding, examiner involvement, and deviations from intended interventions. Despite these limitations, several studies reported favorable effects of specific supplements on OS modulation and post-exercise recovery. Overall, the findings highlight widespread methodological shortcomings and emphasize the need for standardized trial designs, consistent biomarker selection, and transparent reporting. Well-designed, long-term randomized controlled trials are required to establish robust, evidence-based guidelines for dietary supplement use in managing exercise-induced OS in young adults.

Abstract as published, via PubMed.