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Latest Histology research

The 10 most useful histology studies published this week, chosen from Q1 journals and graded on the Oxford CEBM evidence hierarchy. Each paper links to a short summary and the original on PubMed. Updated 22 September 2026.

Top 10 this week

Week of 20 September 2026

  1. 1

    Efficacy of efruxifermin in improving liver fibrosis in patients with metabolic dysfunction-associated steatohepatitis/nonalcoholic steatohepatitis: a systematic review and meta-analysis of randomized controlled trials

    European journal of gastroenterology & hepatology · Q2 journal · SR/MA of RCTs · Evidence level 1 (High) · 5 August 2026

  2. 2

    Beyond Weight Reduction: An Updated Systematic Review and Meta-Analysis of Metabolic Syndrome Components and Metabolic Dysfunction-Associated Steatotic Liver Disease Outcomes After Endoscopic Sleeve Gastroplasty

    Journal of clinical medicine · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 27 August 2026

    In 12-month follow-up of 4,452 obese adults, ESG produced an average 0.33% drop in glycated haemoglobin, along with modest improvements in insulin resistance, triglycerides, LDL cholesterol and liver enzyme scores, while achieving roughly 16% weight loss. Evidence quality was low and the liver benefit may be weight-dependent, so larger randomized trials with biopsy endpoints are still needed.

  3. 3

    Orthobiologic Injections Adjunctive to Cartilage-Preserving Surgery May Improve Outcomes for Focal Knee Chondral Defects: A Systematic Review of Randomized Controlled Trials With Subgroup Meta-analyses

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 18 September 2026

    Orthobiologic injections for knee cartilage defects

  4. 4

    Patient-level predictors of safety and recurrence after cold versus hot snare resection of large, non-pedunculated colorectal polyps: an individual patient data meta-analysis of four randomised-controlled trials

    Gut · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 15 September 2026

    In a pooled analysis of four RCTs involving 1,423 patients with large (at least 20 mm) non-pedunculated polyps, cold snare resection lowered major adverse events to 1.7% versus 5.9% with hot EMR, yet residual or recurrent adenoma rose to 26.5% compared with 12.8%. The trade-off may favor cold snare for sessile serrated lesions or high-risk patients, but higher recurrence-especially in high-grade dysplasia-remains a concern.

  5. 5

    Transfection of Hypoxia-Inducible Factor-1α in Wound Healing: A Systematic Review

    The Journal of surgical research · Q1 journal · SR/MA of RCTs · Evidence level 1 (High) · 17 September 2026

    In seven pre-clinical studies, local application of HIF-1α increased angiogenesis-related gene expression two- to three-fold, boosted circulating angiogenic cells ten-fold, and reduced wound size compared with controls. Treated wounds showed more mature vessels and less necrosis, but the evidence is limited to normal and diabetic mouse models, so human safety and efficacy remain untested.

  6. 6

    Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model

    Journal of clinical medicine · Q1 journal · RCT · Evidence level 1 (High) · 3 September 2026

    Animal model of RV overload, cardiac pathology focus

  7. 7

    The yield of artificial intelligence (GI genius) in Lynch syndrome -A randomized tandem-colonoscopy trial

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · Q1 journal · RCT · Evidence level 1 (High) · 15 September 2026

    AI colonoscopy trial, disease focus

  8. 8

    Plasma Cell Counting Methodology Determines Chronic Endometritis Prevalence

    Reproductive medicine and biology · Q1 journal · Cohort · Evidence level 3 (Low) · 16 September 2026

    Plasma cell counting methodology determines chronic endometritis prevalence

  9. 9

    Orcein is a more sensitive stain than EVG for detecting large vessel (venous) invasion in colorectal cancer

    Histopathology · Q1 journal · Unclassified · Evidence level 5 (Expert Opinion) · 18 September 2026

    Orcein more sensitive than EVG for vessel invasion detection

  10. 10

    Ki67 proliferation indices in advanced jejunoileal well-differentiated neuroendocrine tumours are most prognostic when evaluated in mesenteric tumour deposits

    Histopathology · Q1 journal · Unclassified · Evidence level 5 (Expert Opinion) · 15 September 2026

    Ki67 in neuroendocrine tumors, not normal tissue

Paper of the day, last two weeks

Evidence summaries in Histology

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For healthcare professionals. Summaries are generated by AI from the published abstract and are not medical advice. Read the original paper before changing practice.