Deep Dive — Evidence Details
References
- [1]
Kidane B, Bott M, Spicer J et al.. “The American Association for Thoracic Surgery (AATS) 2023 Expert Consensus Document: Staging and multidisciplinary management of patients with early-stage non-small cell lung cancer.” The Journal of thoracic and cardiovascular surgery (2023). PMID: 37306641 ↗
L5GUIDELINECited in: Bottom Line, Current Evidence and Standard, On the Horizon - [2]
Scherpereel A, Martin E, Brouchet L et al.. “Reaching multidisciplinary consensus on the management of non-bulky/non-infiltrative stage IIIA N2 non-small cell lung cancer.” Lung cancer (Amsterdam, Netherlands) (2023). PMID: 36682142 ↗
L5GUIDELINECited in: Bottom Line, Current Evidence and Standard, On the Horizon - [3]
. “[Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2025 edition)].” Zhonghua zhong liu za zhi [Chinese journal of oncology] (2025). PMID: 40796288 ↗
L5GUIDELINECited in: Bottom Line, Current Evidence and Standard - [4]
Bertoglio P, Gallina FT, Balzani E et al.. “Surgical outcomes after neoadjuvant chemoimmunotherapy for resectable NSCLC: a systematic review and meta-analysis.” European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2026). PMID: 42000405 ↗
L1SR_OBSCited in: Bottom Line, Current Evidence and Standard - [5]
Barbosa S, de Siqueira Silva A, Rodrigues LB. “Robotic-assisted versus video-assisted thoracoscopic surgery for non-small cell lung cancer after neoadjuvant immunotherapy: a systematic review and meta-analysis.” Journal of robotic surgery (2026). PMID: 41931195 ↗
L1SR_OBSCited in: Bottom Line, Current Evidence and Standard - [6]
Liu W, Feng Z, Zhang M et al.. “Predicting neoadjuvant immunotherapy efficacy with machine learning models in non-small cell lung cancer: A systematic review and meta analysis.” International journal of medical informatics (2026). PMID: 41719848 ↗
L1SR_OBSCited in: Bottom Line, Current Evidence and Standard - [7]
Spicer JD, Cascone T, Wynes MW et al.. “Neoadjuvant and Adjuvant Treatments for Early Stage Resectable NSCLC: Consensus Recommendations From the International Association for the Study of Lung Cancer.” Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024). PMID: 38901648 ↗
L5OTHERCited in: Bottom Line, Current Evidence and Standard, On the Horizon - [8]
Kim SS, Cooke DT, Kidane B et al.. “The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer.” The Annals of thoracic surgery (2024). PMID: 39424119 ↗
L5REVIEW_NARRATIVECited in: Bottom Line, Current Evidence and Standard, On the Horizon - [9]
Mitome N, Hamada A, Wakabayashi M et al.. “A Multi-Institutional Randomized Phase III Trial of Neoadjuvant Chemoimmunotherapy Followed By Surgery Versus Upfront Surgery in Patients With Resectable Clinical Stage II-III Non-Small Cell Lung Cancer: JCOG2317 (NATCH-ICI).” Clinical lung cancer (2026). PMID: 42107198 ↗
L1RCTCited in: Bottom Line, Current Evidence and Standard - [10]
Provencio M, Awad MM, Spicer JD et al.. “Clinical outcomes with perioperative nivolumab by nodal status in patients with stage III resectable NSCLC: phase 3 CheckMate 77T exploratory analysis.” Nature cancer (2026). PMID: 41507539 ↗
L1RCTCited in: Bottom Line, Current Evidence and Standard, Applicability and Caveats - [11]
Tanaka F, Watanabe Y, Sugawara S et al.. “Perioperative Nivolumab in Resectable Non-Small Cell Lung Cancer: A Subanalysis of Japanese Patients From CheckMate 77T.” Cancer science (2025). PMID: 41431434 ↗
L1RCTCited in: Bottom Line, Current Evidence and Standard, Applicability and Caveats - [12]
Cuppens K, Wiesweg M, Baas P et al.. “Long-term outcomes of preoperative nivolumab with or without relatlimab in patients with resectable non-small-cell lung cancer (NEOpredict-Lung).” European journal of cancer (Oxford, England : 1990) (2025). PMID: 41389771 ↗
L1RCTCited in: Bottom Line, Current Evidence and Standard, Applicability and Caveats - [13]
Wang C, Wang W, Liu H et al.. “Perioperative tislelizumab plus neoadjuvant chemotherapy for patients with resectable non-small-cell lung cancer: final analysis of the randomized RATIONALE-315 trial.” Annals of oncology : official journal of the European Society for Medical Oncology (2025). PMID: 41344593 ↗
L1RCTCited in: Bottom Line, Current Evidence and Standard - [14]
Martin LW, Wang X, Kozono D et al.. “CHIO3: CHemotherapy combined with immune checkpoint inhibitor for operable stage IIIA/B (N2) Non-Small cell lung cancer (AFT-46).” Lung cancer (Amsterdam, Netherlands) (2026). PMID: 41880691 ↗
L4TRIAL_NONRANDOMCited in: Bottom Line, Current Evidence and Standard - [15]
Yan Y, Han Y, Niu Z et al.. “Conversion Surgery After Induction Therapy for Initially Unresectable Stage III Non-small Cell Lung Cancer: A Proof-of-Concept Trial.” Annals of surgical oncology (2026). PMID: 41880079 ↗
L4TRIAL_NONRANDOMCited in: Bottom Line, Current Evidence and Standard - [16]
Zhai W, Liang D, Yu X et al.. “Surgery after neoadjuvant immunochemotherapy versus immuno-chemoradiotherapy in patients with cN3 non-small cell lung cancer: A cohort study in two academic centers.” Lung cancer (Amsterdam, Netherlands) (2026). PMID: 41980306 ↗
L3COHORTCited in: Current Evidence and Standard - [17]
Pan Y, Sun C, Xu H et al.. “Pathologic response and nodal status guide adjuvant immunotherapy in non-small cell lung cancer after neoadjuvant chemoimmunotherapy: An eastern Asian cohort study.” The Journal of thoracic and cardiovascular surgery (2026). PMID: 41765326 ↗
L3COHORTCited in: Current Evidence and Standard - [18]
Zhang W, Dai T, Wang D et al.. “Efficacy of neoadjuvant PD-1/PD-L1 inhibitor in resectable NSCLC: a meta-analysis based on randomized controlled trials.” BMC cancer (2024). PMID: 39696048 ↗
L1SR_MA_RCTCited in: Applicability and Caveats, On the Horizon - [19]
de Moraes FCA, Pasqualotto E, de Oliveira Rodrigues ALS et al.. “Racial/ethnic differences in survival and treatment response with PD-1/PD-L1 inhibitors in resectable non-small cell lung cancer: a meta-analysis of randomized controlled trials.” European journal of clinical pharmacology (2024). PMID: 39542906 ↗
L1SR_MA_RCTCited in: Applicability and Caveats - [20]
Teodonio L, Peritore V, Andreetti C. “Current indications for surgery in patients with lung cancer after neoadjuvant targeted therapy: a systematic review.” Updates in surgery (2025). PMID: 40996635 ↗
L2SR_OBSCited in: Applicability and Caveats - [21]
Zhang Z, Lin Y, Chen S. “Efficacy of neoadjuvant, adjuvant, and perioperative immunotherapy in non-small cell lung cancer across different PD-L1 expression levels: a systematic review and meta-analysis.” Frontiers in immunology (2025). PMID: 40463367 ↗
L1SR_OBSCited in: Applicability and Caveats - [22]
Yang X, Xing Z, Long S et al.. “Comparative effectiveness for early-stage NSCLC without lymph node involvement based on prospective studies.” International journal of surgery (London, England) (2025). PMID: 40434735 ↗
L1SR_OBSCited in: Applicability and Caveats - [23]
Liu Y, Long J, Deng H et al.. “Neoadjuvant immunotherapy for NSCLC: superior combination strategies, optimal treatment cycles, and predictive indicators from a Bayesian meta-analysis.” Frontiers in immunology (2025). PMID: 40213564 ↗
L1SR_OBSCited in: Applicability and Caveats - [24]
Nuccio A, Salomone F, Servetto A et al.. “Neoadjuvant vs perioperative chemo-immunotherapy according to pathological response in resectable non-small cell lung cancer: a reconstructed individual patient data meta-analysis.” Journal of the National Cancer Institute (2025). PMID: 40210599 ↗
L1SR_OBSCited in: Applicability and Caveats - [25]
. “[Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2023 edition)].” Zhonghua zhong liu za zhi [Chinese journal of oncology] (2023). PMID: 37460438 ↗
L5GUIDELINECited in: On the Horizon - [26]
Chen K, Wang X, Yue R et al.. “Efficacy and safety of immune checkpoint inhibitors as neoadjuvant therapy in perioperative patients with non-small cell lung cancer: a network meta-analysis and systematic review based on randomized controlled trials.” Frontiers in immunology (2024). PMID: 39416776 ↗
L1SR_MA_RCTCited in: On the Horizon - [27]
Patel AJ, Hemead H, Law J et al.. “Impact of the timing of immunotherapy administration on overall survival for resectable non-small cell lung cancer (iACORN study): A systematic review and meta-analysis of randomised trials.” European journal of cancer (Oxford, England : 1990) (2024). PMID: 39551030 ↗
L1SR_OBSCited in: On the Horizon - [28]
Marinelli D, Nuccio A, Di Federico A et al.. “Improved Event-Free Survival After Complete or Major Pathologic Response in Patients With Resectable NSCLC Treated With Neoadjuvant Chemoimmunotherapy Regardless of Adjuvant Treatment: A Systematic Review and Individual Patient Data Meta-Analysis.” Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024). PMID: 39389220 ↗
L1SR_OBSCited in: On the Horizon - [29]
Han Y, Xiao X, Qin T et al.. “Efficacy and safety of perioperative immunotherapy combinations for resectable non-small cell lung cancer: a systematic review and network meta-analysis.” Cancer immunology, immunotherapy : CII (2024). PMID: 39382658 ↗
L1SR_OBSCited in: On the Horizon - [30]
Zhou N, Leung CH, William WN et al.. “Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancer.” Journal for immunotherapy of cancer (2024). PMID: 39448200 ↗
L2RCTCited in: On the Horizon - [31]
Ross HJ, Kozono D, Wang XF et al.. “Atezolizumab Before and After Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer: A Phase II Nonrandomized Controlled Trial.” JAMA oncology (2024). PMID: 39052256 ↗
L2RCTCited in: On the Horizon - [32]
Papaporfyriou A, Bartziokas K, Apessos I et al.. “Comparative Efficacy and Safety of Neoadjuvant Immunotherapy with Nivolumab vs. Pembrolizumab in Resectable Non-Small Cell Lung Cancer: A Systematic Review.” Current oncology (Toronto, Ont.) (2024). PMID: 39451773 ↗
L5SR_OBSCited in: On the Horizon
