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Vascular Medicine›Condition·Updated Apr 17, 2026·v1

Deep Vein Thrombosis

Deep vein thrombosis is a common and potentially lethal condition requiring a high index of suspicion. Diagnosis is streamlined through the Wells score and D-dimer, with compression ultrasound providing definitive evidence. Modern management favors DOACs for their ease of use and safety profile, while LMWH remains the standard for pregnancy and cancer. Long-term care focuses on preventing recurrence and managing the sequelae of chronic venous insufficiency.

High Evidence189 references·6,288 words·26 min read·v1
Vascular MedicineHematologyEmergency MedicineVenous ThromboembolismAnticoagulation

Quick Reference

RxDrug of choiceApixaban (10mg BID x7d, then 5mg BID) or Rivaroxaban (15mg BID x21d, then 20mg daily)
AltAlternativesEnoxaparin (1mg/kg BID) followed by Warfarin (Target INR 2.0-3.0) or Edoxaban
⊘AvoidDOACs in pregnancy; DOACs in mechanical heart valves; DOACs in triple-positive Antiphospholipid Syndrome
DxTest of choiceCompression Ultrasonography (CUS)
ScKey scoreWells Criteria for DVT
→When to referPhlegmasia cerulea dolens (emergency); contraindication to anticoagulation (for IVC filter); recurrent DVT on therapy; suspected May-Thurner syndrome
Diagnose via Wells score and ultrasound; treat with 3-6 months of DOACs for provoked cases and consider indefinite therapy for unprovoked or high-risk patients.
Deep vein thrombosis (DVT) is the formation of a blood clot within the deep venous system, most commonly in the lower extremities, and represents a critical component of venous thromboembolism (VTE). The primary clinical danger of DVT is the acute risk of embolization to the lungs, resulting in a potentially fatal [[pulmonary embolism]] (PE), and the long-term risk of post-thrombotic syndrome (PTS), which causes chronic venous hypertension, pain, and ulceration. Diagnosis relies on integrating clinical probability scores, such as the Wells criteria, with D-dimer testing and compression ultrasonography. Management has shifted significantly toward direct oral anticoagulants (DOACs) as first-line therapy for most patients, though specific populations like pregnant women or those with massive limb-threatening swelling (phlegmasia) require specialized interventions. Early recognition and rapid initiation of anticoagulation are the cornerstones of preventing morbidity and mortality.

Overview and Recommendations

Background

  • •Define deep vein thrombosis as the presence of a thrombus in the deep veins, which are surrounded by muscle and carry the majority of venous return, as opposed to superficial veins. DVT and are considered two manifestations of the same disease process, VTE, sharing the same risk factors and management principles.
  • •Classify DVT by anatomical location into proximal and distal (isolated calf) variants. Proximal DVT involves the popliteal, femoral, or iliac veins and carries a much higher risk of PE and PTS, whereas distal DVT is confined to the calf veins (posterior tibial, anterior tibial, and peroneal) and has a lower, though non-zero, risk of propagation.
  • •Understand the etiologic distinction between provoked and unprovoked DVT to guide the duration of therapy. Provoked DVT occurs in the setting of transient risk factors like major surgery, trauma, or immobilization, while unprovoked DVT occurs without an obvious trigger and suggests a higher baseline risk of recurrence.
  • •Recognize the role of Virchow’s Triad—venous stasis, endothelial injury, and hypercoagulability—in the pathogenesis of clot formation. Common triggers include malignancy, pregnancy, hormonal therapy, and inherited thrombophilias such as Factor V Leiden.
  • •Identify life-threatening variants such as phlegmasia cerulea dolens, which is characterized by massive venous occlusion leading to limb cyanosis and potential arterial compromise. This is a surgical emergency that requires aggressive intervention to prevent gangrene and limb loss.

Evaluation

  • •Suspect DVT in any patient presenting with unilateral leg pain, swelling, warmth, or erythema. While these signs are non-specific, the presence of a 'heavy' sensation in the limb or pain that worsens with weight-bearing should increase clinical suspicion.
  • •Perform a focused physical examination comparing the affected limb to the contralateral side. Measure the calf circumference 10 cm below the tibial tuberosity; a difference of >3 cm is a significant predictor of DVT.
  • •Assess for pitting edema and the presence of prominent, non-varicose collateral superficial veins. Palpate along the course of the deep veins to identify localized tenderness, particularly in the popliteal fossa or along the medial thigh.
  • •Calculate the Wells Score for DVT to categorize the patient’s pre-test probability as low (0 points), moderate (1-2 points), or high (≥3 points). This score includes factors such as active cancer, recent immobilization, and the absence of a more likely alternative diagnosis.
  • •Order a high-sensitivity D-dimer test for patients with a low or moderate pre-test probability. A negative D-dimer (<500 ng/mL or age-adjusted threshold) effectively rules out DVT in these groups without the need for imaging.
  • •Apply age-adjusted D-dimer thresholds for patients over 50 years old to improve specificity. The formula is age × 10 µg/L (e.g., a 70-year-old has a cutoff of 700 µg/L).
  • •Obtain a compression ultrasonography (CUS) as the first-line imaging study for patients with a high Wells score or a positive D-dimer. The diagnostic hallmark is the non-compressibility of a venous segment under the ultrasound probe.
  • •Utilize whole-leg ultrasound if there is high suspicion of distal (calf) DVT, though many protocols focus on proximal CUS (groin to popliteal) due to the higher clinical significance of proximal clots.
  • •Consider CT or MR venography for suspected DVT in atypical locations, such as the iliac veins, vena cava, or upper extremities, especially when CUS is inconclusive or technically limited by body habitus.
  • •Rule out common mimics such as , ruptured Baker’s cyst (popliteal cyst), muscle tear (e.g., 'tennis leg'), or lymphedema. Cellulitis typically presents with higher fever and more diffuse erythema, while a ruptured cyst often shows a 'crescent sign' of bruising near the malleolus.
  • •Screen for underlying malignancy in patients with a first-time unprovoked DVT. This should generally be limited to age-appropriate cancer screening (e.g., colonoscopy, mammography) rather than extensive 'fishing' with whole-body CT scans unless symptoms suggest a specific primary site.

Management

  • •Initiate anticoagulation immediately upon diagnostic confirmation, or even prior to imaging if suspicion is high and the bleeding risk is low. The primary goal is to prevent thrombus propagation and embolization.
  • •Administer direct oral anticoagulants (DOACs) as first-line therapy for most non-pregnant patients. Apixaban is dosed at 10 mg BID for 7 days followed by 5 mg BID; Rivaroxaban is dosed at 15 mg BID for 21 days followed by 20 mg daily.
  • •Utilize Low-Molecular-Weight Heparin (LMWH), such as Enoxaparin 1 mg/kg every 12 hours, as the preferred agent for patients with active malignancy or those who are pregnant. LMWH is also used as a bridge for patients starting Warfarin.
  • •Prescribe Warfarin for patients with severe renal failure (CrCl <15 mL/min) or (APS). Target an International Normalized Ratio (INR) of 2.0–3.0, maintaining LMWH bridging until the INR is therapeutic for at least 24 hours.
  • •Treat provoked DVT (e.g., post-surgery) for a fixed duration of 3 months. Extending therapy beyond 3 months in these cases increases bleeding risk without significantly reducing recurrence.
  • •Consider indefinite anticoagulation for patients with unprovoked DVT or persistent risk factors like active cancer, provided the bleeding risk is acceptable. Re-evaluate the risk-benefit ratio annually.
  • •Avoid the routine use of Inferior Vena Cava (IVC) filters. These should be reserved strictly for patients with proven acute proximal DVT who have an absolute contraindication to anticoagulation (e.g., active intracranial hemorrhage).
  • •Refer patients with phlegmasia cerulea dolens or massive iliofemoral DVT with impending limb ischemia for catheter-directed thrombolysis or surgical thrombectomy. These interventions are not indicated for routine DVT.
  • •Encourage early ambulation as soon as therapeutic anticoagulation is achieved. Bed rest does not reduce the risk of PE and may actually promote further stasis and clot propagation.
  • •Prescribe graduated compression stockings (30–40 mmHg) for symptomatic relief of edema, though they are no longer routinely recommended solely for the prevention of post-thrombotic syndrome based on recent trial data.
  • •Monitor for treatment-related bleeding. Educate patients on signs of hemorrhage and the importance of medication adherence. For patients on DOACs, routine coagulation monitoring (PT/INR) is not required.
  • •Manage isolated distal (calf) DVT with either 3 months of anticoagulation or serial ultrasound monitoring over 2 weeks. Anticoagulation is preferred if the patient is severely symptomatic or has high-risk features for propagation.
  • •Evaluate for May-Thurner Syndrome in young patients, particularly women, presenting with left-sided iliofemoral DVT. This involves compression of the left common iliac vein by the right common iliac artery and may require stenting after initial anticoagulation.

Board Review — High Yield

  • •Wells Score — A score of ≥3 indicates high probability; <2 with a negative D-dimer rules out DVT.
  • •Age-adjusted D-dimer — Use (Age x 10) ng/mL for patients >50 years to reduce false positives.
  • •Phlegmasia cerulea dolens — Massive venous congestion causing a cyanotic, painful, swollen limb; high risk of gangrene.
  • •May-Thurner Syndrome — Compression of the left common iliac vein by the right common iliac artery; suspect in young females with left-leg DVT.
  • •Paget-Schroetter Syndrome — Upper extremity DVT caused by repetitive overhead activity (effort thrombosis).
  • •Post-thrombotic Syndrome (PTS) — Chronic complication featuring edema, skin hyperpigmentation, and ulcers due to venous valve damage.
  • •Trousseau Syndrome — Migratory superficial thrombophlebitis associated with visceral malignancy (especially pancreatic cancer).
  • •Factor V Leiden — The most common inherited thrombophilia; caused by resistance to activated protein C.

Deep Dive — Evidence Details

References

  1. [1]

    Eklof B, Perrin M, Delis KT et al.. “Updated terminology of chronic venous disorders: the VEIN-TERM transatlantic interdisciplinary consensus document.” Journal of vascular surgery (2009). PMID: 19216970 ↗

    L1cGUIDELINECited in: Definition, Synonyms, and Classification
  2. [2]

    Sun CR, Liu MY, Ni QH et al.. “Clinical Guidelines on Compression Therapy in Venous Diseases.” Annals of vascular surgery (2025). PMID: 39032593 ↗

    L1cGUIDELINECited in: Definition, Synonyms, and Classification
  3. [3]

    Stevens SM, Woller SC, Baumann Kreuziger L et al.. “Antithrombotic Therapy for VTE Disease: Compendium and Review of CHEST Guidelines 2012-2021.” Chest (2024). PMID: 38458430 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  4. [4]

    Bayraktar Y. “Portal ductopathy: clinical importance and nomenclature.” World journal of gastroenterology (2011). PMID: 21472098 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  5. [5]

    Kumar A, Sharma P, Arora A. “Review article: portal vein obstruction--epidemiology, pathogenesis, natural history, prognosis and treatment.” Alimentary pharmacology & therapeutics (2015). PMID: 25475582 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  6. [6]

    Shenoy A, Davis JPE. “Contemporary management of portal vein thromboses in patients with and without cirrhosis.” Current opinion in gastroenterology (2025). PMID: 39998941 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  7. [7]

    Bayraktar Y, Harmanci O. “Etiology and consequences of thrombosis in abdominal vessels.” World journal of gastroenterology (2006). PMID: 16534866 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  8. [8]

    Harmanci O, Bayraktar Y. “Portal hypertension due to portal venous thrombosis: etiology, clinical outcomes.” World journal of gastroenterology (2007). PMID: 17552000 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  9. [9]

    Yamagishi T, Hikone M, Sugiyama K et al.. “Purpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report.” BMC infectious diseases (2018). PMID: 30340466 ↗

    L4CASE_REPORTCited in: Definition, Synonyms, and Classification
  10. [10]

    Kahn F, Linder A, Petersson AC et al.. “Axillary abscess complicated by venous thrombosis: identification of Streptococcus pyogenes by 16S PCR.” Journal of clinical microbiology (2010). PMID: 20592151 ↗

    L4CASE_REPORTCited in: Definition, Synonyms, and Classification
  11. [11]

    Kupfer M, Kucer BT, Kupfer H et al.. “Persons With Chronic Spinal Cord Injuries in the Emergency Department: a Review of a Unique Population.” The Journal of emergency medicine (2018). PMID: 29807681 ↗

    L5REVIEW_NARRATIVECited in: Definition, Synonyms, and Classification
  12. [12]

    Comarmond C, Mirault T, Biard L et al.. “Takayasu Arteritis and Pregnancy.” Arthritis & rheumatology (Hoboken, N.J.) (2015). PMID: 26315109 ↗

    L5OTHERCited in: Definition, Synonyms, and Classification
  13. [13]

    de Haan HG, van Hylckama Vlieg A, van der Gaag KJ et al.. “Male-specific risk of first and recurrent venous thrombosis: a phylogenetic analysis of the Y chromosome.” Journal of thrombosis and haemostasis : JTH (2016). PMID: 27495181 ↗

    L5OTHERCited in: Definition, Synonyms, and Classification
  14. [14]

    Zhang X, Durham KM, Garza AA et al.. “Portal vein thrombosis, hepatic decompensation, and survival in patients with porto-sinusoidal vascular disease and portal hypertension.” Journal of gastroenterology (2023). PMID: 36692825 ↗

    L5OTHERCited in: Definition, Synonyms, and Classification
  15. [15]

    Munk MR, Kashani AH, Tadayoni R et al.. “Recommendations for OCT Angiography Reporting in Retinal Vascular Disease: A Delphi Approach by International Experts.” Ophthalmology. Retina (2022). PMID: 35202889 ↗

    L5OTHERCited in: Definition, Synonyms, and Classification
  16. [16]

    Bayona Molano MDP, Brackett W, Mena P et al.. “Complex filter removal using forceps from combined transfemoral and transjugular approach unhooking the filter apex using forceps and dual access: Two case reports.” Journal of cardiac surgery (2022). PMID: 35819367 ↗

    L4CASE_REPORTCited in: Definition, Synonyms, and Classification
  17. [17]

    Shen Y, Jiang Y, Wang Y et al.. “Increased risk of venous thromboembolism in children and teenagers with inflammatory bowel disease: a systematic review and meta-analysis.” PeerJ (2026). PMID: 41940394 ↗

    L2aSR_OBSCited in: Epidemiology and Risk Factors
  18. [18]

    Wen X, Wu H, He Y et al.. “Efficacy and safety of cyanoacrylate ablation vs endovenous radiofrequency ablation for varicose veins in chronic great saphenous vein insufficiency: A systematic review and meta-analysis.” Journal of vascular surgery. Venous and lymphatic disorders (2026). PMID: 41866115 ↗

    L2aSR_OBSCited in: Epidemiology and Risk Factors
  19. [19]

    Das S, Simunovic N, Di Maria F et al.. “Prophylaxis does not prevent symptomatic venous thromboembolism following anterior cruciate ligament surgery: a systematic review and meta-analysis.” Journal of ISAKOS : joint disorders & orthopaedic sports medicine (2026). PMID: 41850529 ↗

    L2aSR_OBSCited in: Epidemiology and Risk Factors
  20. [20]

    Gong M, Kong J, Gu J et al.. “Who benefits from a filter? Developing clinical prediction models for thrombus dislodgement in hospitalized patients with deep vein thrombosis: A multicenter retrospective study.” European journal of radiology (2026). PMID: 41946015 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors, Diagnosis and Workup
  21. [21]

    Chen H, Chen K, Xie X et al.. “Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study.” Frontiers in endocrinology (2026). PMID: 41907552 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors
  22. [22]

    Kou R, Mallick R, Brown C et al.. “Anticoagulation management and outcomes in patients with cancer-associated small venous thromboembolism: a retrospective cohort study.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41791657 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors
  23. [23]

    Wardak YH, Chung YE, Maingard J et al.. “Quality of life following endovascular treatment of proximal lower limb DVT: A systematic review and meta-analysis.” Journal of vascular and interventional radiology : JVIR (2026). PMID: 41905683 ↗

    L2aSR_OBSCited in: Epidemiology and Risk Factors
  24. [24]

    Botolin P, Robles R, Keshishian C et al.. “Impact of Stroke History and Interval on Outcomes of Total Hip Arthroplasty: A Retrospective Cohort Study.” Orthopedics (2026). PMID: 41885516 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors, Diagnosis and Workup
  25. [25]

    Zhai Y, Cao X, Zheng S et al.. “[Comparative observation of analgesic efficacy between liposomal bupivacaine and "cocktail" therapy following artificial intelligence-assisted direct anterior approach total hip arthroplasty: A prospective randomized controlled study].” Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery (2026). PMID: 41981425 ↗

    L1bRCTCited in: Epidemiology and Risk Factors, History and Physical Examination, Diagnosis and Workup
  26. [26]

    Li Y, Wang S, Zhao X. “Risk factors for TIVAD-related venous thrombosis in Chinese breast cancer patients undergoing chemotherapy: A single-center retrospective study.” Medicine (2026). PMID: 41861226 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors, Diagnosis and Workup, Special Populations
  27. [27]

    Skeith L, Bates SM. “Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk.” The New England journal of medicine (2026). PMID: 41985134 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology and Risk Factors
  28. [28]

    Hou J, Mu G, Zhang Z et al.. “Hematological toxicities and thrombosis risk associated with immune checkpoint inhibitors: a pharmacovigilance study from 2014 to 2024.” Cancer immunology, immunotherapy : CII (2026). PMID: 41984243 ↗

    L5OTHERCited in: Epidemiology and Risk Factors, Special Populations
  29. [29]

    Mansour M, Asi AR, Massalha E et al.. “Residual Perfusion Defects after Acute Pulmonary Embolism: Prevalence, Determinants, and Clinical Impact.” The American journal of medicine (2026). PMID: 41941949 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  30. [30]

    Gonzalez HC, Gordon SC, Trudeau S et al.. “Impact of Disease-Specific Treatment and Non-Selective Beta Blockers on Risk of PVT in Cirrhotic Patients With HCV or PBC.” Liver international : official journal of the International Association for the Study of the Liver (2026). PMID: 41933920 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  31. [31]

    Jones GD, Raja S, Ahmad U et al.. “Prospectively Screening for Venous Thromboembolism in Patients with Esophagectomy for Cancer Improves Survival: The Complexity of Simplicity.” The Journal of thoracic and cardiovascular surgery (2026). PMID: 41932434 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  32. [32]

    Sohail A, Powers MT, Suarez T et al.. “Direct Oral Anticoagulants Are Associated With Less Bleeding Risk Than Warfarin in Patients Undergoing Liver Resections.” The Journal of surgical research (2026). PMID: 41921475 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  33. [33]

    Yang L, Zhang Z, Li C et al.. “Effect of different durations of compression therapy on quality of life and recurrence after thermal ablation for varicose veins: a protocol for a prospective, multicenter, randomized controlled trial.” Frontiers in medicine (2026). PMID: 41907264 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  34. [34]

    Yang S, Li G, Li Y et al.. “In-hospital deep vein thrombosis after tibial plateau fractures: incidence, laterality/anatomy, and risk factors in a multicenter retrospective cohort of 3366 patients.” Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology (2026). PMID: 41886203 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  35. [35]

    Horton CE, Wi MS, Sayegh M et al.. “Short-term outcomes of ultrasound-assisted catheter-directed thrombolysis and mechanical thrombectomy in management of intermediate-risk pulmonary embolism.” Journal of vascular surgery. Venous and lymphatic disorders (2026). PMID: 41866114 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  36. [36]

    Mao J, Qin L, Gao M et al.. “Perioperative management of colorectal surgical patients receiving a direct oral anticoagulant: a scoping review, particular emphasis on procedure-specific risks, and pharmacogenomics.” Frontiers in cardiovascular medicine (2026). PMID: 41835471 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology and Risk Factors
  37. [37]

    Doukhi D, Aghetti A, Siguret V et al.. “Specific Features of Cerebral Venous Thrombosis Associated With Iron Deficiency Anemia.” Journal of the American Heart Association (2026). PMID: 41804921 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  38. [38]

    Doiron JE, Corpodean F, Kachmar M et al.. “Prevalence of early marginal ulcer in sleeve to bypass conversions: an analysis of the 2020-2022 MBSAQIP.” Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery (2026). PMID: 41791958 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  39. [39]

    Fu P, Li Y, Wang C et al.. “Deletion of platelet STK10 impairs deep vein thrombus formation.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41791658 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  40. [40]

    Daghlas I, Perez-Alcantara M, Gill D. “Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study.” Neurology (2026). PMID: 41785432 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  41. [41]

    Wu S, Qiu F, Zhang F et al.. “Hepatic arterial infusion chemotherapy combined with apatinib plus camrelizumab for advanced hepatocellular carcinoma with type Vp4 portal vein tumor thrombosis: a multicenter propensity score-matching analysis.” Frontiers in immunology (2026). PMID: 41782861 ↗

    L5OTHERCited in: Epidemiology and Risk Factors, Diagnosis and Workup, Special Populations
  42. [42]

    Ye H, Li J, Du L et al.. “Development and validation of a deep vein thrombosis risk assessment tool for surgical patients aged 75 years and older.” BMC geriatrics (2026). PMID: 41782093 ↗

    L5OTHERCited in: Epidemiology and Risk Factors, Diagnosis and Workup
  43. [43]

    Sobih NM, Vellema J, van de Munckhof A et al.. “Impact of anaemia severity on functional outcome in patients with cerebral venous thrombosis: a DOAC-CVT substudy.” European stroke journal (2026). PMID: 41758562 ↗

    L5OTHERCited in: Epidemiology and Risk Factors
  44. [44]

    Ke X, Liu Y, Chen X et al.. “Association between preoperative anemia and postoperative delirium in elderly patients undergoing total hip arthroplasty with combined spinal-epidural anesthesia: A retrospective cohort study.” Journal of anesthesia and translational medicine (2025). PMID: 41929925 ↗

    L2bCOHORTCited in: Epidemiology and Risk Factors
  45. [45]

    Kamada K, Fukaya E, Iwata E et al.. “Disaster-associated venous thromboembolism countermeasures in Japan: Insights from past major earthquakes.” Journal of vascular surgery. Venous and lymphatic disorders (2026). PMID: 40935330 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors, Pathophysiology
  46. [46]

    Liu S, Shen Y, Chen J et al.. “The critical role of platelets in venous thromboembolism: Pathogenesis, clinical status, and emerging therapeutic strategies.” Blood reviews (2025). PMID: 40382294 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors, Pathophysiology
  47. [47]

    Muscat-Baron L, Borg AL, Attard LM et al.. “Cancer-Associated Abdominal Vein Thrombosis.” Cancers (2023). PMID: 37958466 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  48. [48]

    Johnson RR, Faustino EVS. “Central venous catheter-associated deep vein thrombosis in critically ill pediatric patients: risk factors, prevention, and treatment.” Current opinion in pediatrics (2022). PMID: 35634701 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  49. [49]

    Hembrom AA, Srivastava S, Garg I et al.. “MicroRNAs in venous thrombo-embolism.” Clinica chimica acta; international journal of clinical chemistry (2020). PMID: 32017924 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  50. [50]

    Caprini JA. “Risk assessment as a guide for the prevention of the many faces of venous thromboembolism.” American journal of surgery (2010). PMID: 20103082 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  51. [51]

    Levine MN. “Adjuvant therapy and thrombosis: how to avoid the problem?” Breast (Edinburgh, Scotland) (2007). PMID: 17720502 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  52. [52]

    Didembourg M, Morimont L, De Gottal E et al.. “The maternal hemostatic shift: Understanding VTE risk in pregnancy and postpartum.” Thrombosis research (2026). PMID: 41352199 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors, Pathophysiology, Special Populations
  53. [53]

    Mehta JL, Calcaterra G, Bassareo PP. “COVID-19, thromboembolic risk, and Virchow's triad: Lesson from the past.” Clinical cardiology (2020). PMID: 33176009 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  54. [54]

    Liu A, Minasian RA, Maniago E et al.. “Venous Thromboembolism Chemoprophylaxis in Burn Patients: A Literature Review and Single-Institution Experience.” Journal of burn care & research : official publication of the American Burn Association (2021). PMID: 32842151 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  55. [55]

    Stone J, Hangge P, Albadawi H et al.. “Deep vein thrombosis: pathogenesis, diagnosis, and medical management.” Cardiovascular diagnosis and therapy (2017). PMID: 29399531 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  56. [56]

    Byrnes JR, Wolberg AS. “New findings on venous thrombogenesis.” Hamostaseologie (2017). PMID: 27878206 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  57. [57]

    Congly SE, Lee SS. “Portal vein thrombosis: should anticoagulation be used?” Current gastroenterology reports (2013). PMID: 23314804 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  58. [58]

    López JA, Chen J. “Pathophysiology of venous thrombosis.” Thrombosis research (2009). PMID: 19303501 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  59. [59]

    Haas P, Landgraf H. “Studies on travel-related thrombosis.” VASA. Zeitschrift fur Gefasskrankheiten (2008). PMID: 19003739 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  60. [60]

    Merli GJ. “Pathophysiology of venous thrombosis, thrombophilia, and the diagnosis of deep vein thrombosis-pulmonary embolism in the elderly.” Clinics in geriatric medicine (2006). PMID: 16377468 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  61. [61]

    Savulescu-Fiedler I, Siliste RN, Homentcovschi C et al.. “The role of endothelial cell protein C receptor gene polymorphism in venous thromboembolic disease: a case report and literature review.” Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (2025). PMID: 40643034 ↗

    L4CASE_REPORTCited in: Etiology and Triggering Factors, Pathophysiology
  62. [62]

    Sasson I, Sorin V, Ziv-Baran T et al.. “Unexpected early pulmonary thrombi in war injured patients.” European radiology (2026). PMID: 40833493 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  63. [63]

    Gebhard CE, Zellweger N, Gebhard C et al.. “Prone Positioning as a Potential Risk Factor for Deep Vein Thrombosis in COVID-19 Patients: A Hypothesis Generating Observation.” Journal of clinical medicine (2021). PMID: 35011843 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  64. [64]

    Rajeeva Pandian NK, Walther BK, Suresh R et al.. “Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis.” Small (Weinheim an der Bergstrasse, Germany) (2020). PMID: 33205630 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  65. [65]

    Lurie JM, Png CYM, Subramaniam S et al.. “Virchow's triad in "silent" deep vein thrombosis.” Journal of vascular surgery. Venous and lymphatic disorders (2019). PMID: 31078515 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  66. [66]

    Alturki N, Alkahtani M, Daghistani M et al.. “Incidence and risk factors for deep vein thrombosis among pediatric burn patients.” Burns : journal of the International Society for Burn Injuries (2019). PMID: 31018912 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  67. [67]

    Avila ML, Duan L, Cipolla A et al.. “Postthrombotic syndrome following upper extremity deep vein thrombosis in children.” Blood (2014). PMID: 24957144 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  68. [68]

    Wilson TJ, Brown DL, Meurer WJ et al.. “Risk factors associated with peripherally inserted central venous catheter-related large vein thrombosis in neurological intensive care patients.” Intensive care medicine (2012). PMID: 22113818 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  69. [69]

    Bittencourt PL, Couto CA, Ribeiro DD. “Portal vein thrombosis and budd-Chiari syndrome.” Clinics in liver disease (2009). PMID: 19150317 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  70. [70]

    Bagot CN, Arya R. “Virchow and his triad: a question of attribution.” British journal of haematology (2008). PMID: 18783400 ↗

    L5OTHERCited in: Etiology and Triggering Factors
  71. [71]

    Shaydakov ME, Diaz JA, Eklöf B et al.. “Venous valve hypoxia as a possible mechanism of deep vein thrombosis: a scoping review.” International angiology : a journal of the International Union of Angiology (2024). PMID: 38864688 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  72. [72]

    Sapota-Zaręba K, Nasierowski T. “The risk of pulmonary embolism in the context of various clinical situations and management in psychiatric patients.” Psychiatria polska (2023). PMID: 38345121 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  73. [73]

    Malone PC, Agutter PS. “The aetiology of deep venous thrombosis.” QJM : monthly journal of the Association of Physicians (2006). PMID: 16905749 ↗

    L5REVIEW_NARRATIVECited in: Etiology and Triggering Factors
  74. [74]

    Stojanovic M, Djuric M, Nenadic I et al.. “Vascular Complications of Long COVID-From Endothelial Dysfunction to Systemic Thrombosis: A Systematic Review.” International journal of molecular sciences (2025). PMID: 41516301 ↗

    L2aSR_OBSCited in: Pathophysiology
  75. [75]

    Gandhi SD, Mohanty S, von Riegen H et al.. “Efficacy and Safety of Chemical Venous Thromboembolism Prophylaxis in Spine Trauma Patients: A Systematic Review and Meta-analysis Comparing Anticoagulant Types.” Clinical spine surgery (2026). PMID: 40071770 ↗

    L2aSR_OBSCited in: Pathophysiology
  76. [76]

    Shi H, Zhao Y, Shi X et al.. “Effects of traditional Chinese medicine decoctions on coagulation and deep vein thrombosis after total hip arthroplasty: Network meta-analysis.” Explore (New York, N.Y.) (2026). PMID: 41232428 ↗

    L2aSR_OBSCited in: Pathophysiology
  77. [77]

    Krupa-Zabiegała J, Michel PS, Stępień K et al.. “Higher citrullinated histone H3 is associated with postthrombotic syndrome: a cohort study.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41192568 ↗

    L2bCOHORTCited in: Pathophysiology
  78. [78]

    Peng J, Long S, Feng L. “Deep Vein Thrombosis Prevention in Acute Ischemic Stroke Patients with Lower Limb Paralysis: A Narrative Review.” Journal of clinical medicine (2026). PMID: 41899016 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  79. [79]

    Sparić R, Stojković M, Šarac M et al.. “Venous Thromboembolism Associated with Uterine Fibroids: A Review of Reported Cases.” Journal of clinical medicine (2026). PMID: 41598382 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology, History and Physical Examination
  80. [80]

    Albasanz-García P, Ward MP, Norris LA. “Mechanisms of anticancer treatment-induced arterial and venous thrombosis.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41203043 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  81. [81]

    Limper U, Jordan J. “Neck-vein thrombosis during spaceflight.” British journal of clinical pharmacology (2026). PMID: 41035389 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  82. [82]

    Piazza G, Krishnathasan D, Hamade N et al.. “Superficial Vein Thrombosis: A Review.” JAMA (2025). PMID: 40952730 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  83. [83]

    Dhar R, Dos Passos RR, Gower RM et al.. “Toward targeting of inflammasome signaling in venous thrombosis.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 40946806 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  84. [84]

    Galanaud JP, Laroche JP, Righini M. “The history and historical treatments of deep vein thrombosis: toward the era of new anticoagulants.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 40714194 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  85. [85]

    Shao W, Wang Z, Wu J et al.. “Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis.” Frontiers in immunology (2025). PMID: 40510367 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  86. [86]

    Byun JH, Jung J, Woo J. “Clonal hematopoiesis and thromboembolic diseases: a review.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 40499722 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  87. [87]

    Badulescu OV, Ciocoiu M, Vladeanu MC et al.. “The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.” International journal of molecular sciences (2025). PMID: 40141398 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  88. [88]

    Budnik I, Kumskova M, Chauhan AK. “Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention.” Blood (2025). PMID: 40132161 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  89. [89]

    Davis J, Maranto M, Kennedy J et al.. “Transforming Growth Factors in Venous Thrombus Formation and Resolution.” Arteriosclerosis, thrombosis, and vascular biology (2025). PMID: 40109257 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  90. [90]

    Cox C, Roberts LN. “Basics of diagnosis and treatment of venous thromboembolism.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 39938684 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  91. [91]

    Secades D, Dufner Krieger S, Hidalgo Ramos RA et al.. “Incidence of Deep Vein Thrombosis in Patients With COVID-19: A Systematic Review.” Cureus (2025). PMID: 40861621 ↗

    L2aSR_OBSCited in: Pathophysiology
  92. [92]

    Papadakis E, Gavriilaki E, Kotsiou N et al.. “Fright of Long-Haul Flights: Focus on Travel-Associated Thrombosis.” Seminars in thrombosis and hemostasis (2025). PMID: 40015328 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  93. [93]

    Kell DB, Pretorius E. “The Proteome Content of Blood Clots Observed Under Different Conditions: Successful Role in Predicting Clot Amyloid(ogenicity).” Molecules (Basel, Switzerland) (2025). PMID: 39942772 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology
  94. [94]

    Denorme F, Portier I, Castro H et al.. “Platelet mTOR Is a Regulator of Sterile Immunothrombosis.” Arteriosclerosis, thrombosis, and vascular biology (2026). PMID: 41783929 ↗

    L5OTHERCited in: Pathophysiology
  95. [95]

    Shen YJ, Nie ZY, Zhang JQ et al.. “Cyanidin-3-O-glucoside promotes late-stage venous thrombus resolution in mice, accompanied by reduced macrophage M1-associated inflammation and attenuated HIF-1α-linked signaling.” Food & function (2026). PMID: 41734240 ↗

    L5OTHERCited in: Pathophysiology
  96. [96]

    Chen C, Ge X, Fu D et al.. “Endothelial Cell-Specific Molecule-1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis.” Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2026). PMID: 41517829 ↗

    L5OTHERCited in: Pathophysiology
  97. [97]

    Suzuki N, Suzuki A, Tamura S et al.. “Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model.” Arteriosclerosis, thrombosis, and vascular biology (2026). PMID: 41503699 ↗

    L5OTHERCited in: Pathophysiology
  98. [98]

    Wongweerakit O, Sangthong B, Akaraborworn O et al.. “De novo pulmonary embolism following chest trauma: fact or fiction?” European journal of trauma and emergency surgery : official publication of the European Trauma Society (2025). PMID: 41410754 ↗

    L5OTHERCited in: Pathophysiology
  99. [99]

    Noda H, Yutani C, Takahashi S et al.. “Morphological Visualization of Thrombi During Catheter-Directed Fibrinolytic Therapy for Pulmonary Thromboembolism.” The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2026). PMID: 41292114 ↗

    L5OTHERCited in: Pathophysiology
  100. [100]

    Shi TL, Yang ZB, Zhang YQ et al.. “Vibration-stimulation device-assisted enhanced recovery after lower limb fracture surgery: A randomized controlled trial.” International orthopaedics (2026). PMID: 41413326 ↗

    L1bRCTCited in: History and Physical Examination
  101. [101]

    Betensky M, Mosha M, Ashour D et al.. “Postthrombotic syndrome-related chronic limb pain in children: findings from the Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) trial.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41407160 ↗

    L1bRCTCited in: History and Physical Examination
  102. [102]

    Le Gal G, Robert-Ebadi H, Thiruganasambandamoorthy V et al.. “Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis.” JAMA (2026). PMID: 41490105 ↗

    L2bTRIAL_NONRANDOMCited in: History and Physical Examination
  103. [103]

    Kang T, Han S, Lu YL et al.. “Artificial intelligence risk stratification from dynamic digital subtraction angiography radiomics predicts pulmonary embolism and associates with clinical outcomes in deep vein thrombosis: A retrospective cohort study.” Journal of vascular surgery. Venous and lymphatic disorders (2026). PMID: 41638306 ↗

    L2bCOHORTCited in: History and Physical Examination
  104. [104]

    Simard C, Le Gal G, Lazo-Langner A et al.. “Association Between Bariatric Surgery and the Long-Term Risk for Venous Thromboembolism: A Population-Based Matched Cohort Study.” American journal of hematology (2026). PMID: 41588795 ↗

    L2bCOHORTCited in: History and Physical Examination
  105. [105]

    Klimitz FJ, Knoedler S, Fabi A et al.. “Weighing the Risk: The Impact of Obesity on 30-Day Complications After Cosmetic Abdominoplasty-An Observational Cohort Study of 1,778 Cases.” Aesthetic plastic surgery (2026). PMID: 41201611 ↗

    L2bCOHORTCited in: History and Physical Examination
  106. [106]

    Ye Y, Mahati S, Aihemaiti W et al.. “A postpartum-adapted algorithm for safe management of suspected pulmonary embolism: a retrospective cohort study.” American journal of obstetrics and gynecology (2026). PMID: 41183725 ↗

    L2bCOHORTCited in: History and Physical Examination
  107. [107]

    . “[Guidelines for the management of cerebral venous thrombosis during pregnancy and the puerperium (2025 edition)].” Zhonghua yi xue za zhi (2025). PMID: 41145272 ↗

    L1cGUIDELINECited in: History and Physical Examination
  108. [108]

    Abbattista M, Truma A, Martinelli I et al.. “The risk of cerebral vein thrombosis associated with different types of combined hormonal contraceptives: a case-control study.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 40617503 ↗

    L3bCASE_CONTROLCited in: History and Physical Examination
  109. [109]

    Li S, Wang M, Xu Y. “Predictors of pulmonary infarction in pediatric pulmonary embolism: A retrospective cohort study.” Thrombosis research (2025). PMID: 41086550 ↗

    L2bCOHORTCited in: History and Physical Examination
  110. [110]

    Ajrawat P, Price B, Gooch D et al.. “Assessing Postoperative Pain in Patients Who Underwent Total Knee Arthroplasty Using an Automated Self-Logging Patient-Reported Outcome Measure Collection Device: Retrospective Cohort Study.” JMIR human factors (2025). PMID: 40638842 ↗

    L2bCOHORTCited in: History and Physical Examination
  111. [111]

    Ren Y, Liu R. “Prevalence and risk factors of deep vein thrombosis in elderly: a systematic review and meta-analysis.” Open medicine (Warsaw, Poland) (2026). PMID: 41726136 ↗

    L2aSR_OBSCited in: History and Physical Examination
  112. [112]

    Kargar-Soleimanabad S, Najafi S, Ahmadi M et al.. “Diagnostic value of the wells score for lower extremity deep vein thrombosis in hospitalized patients: A case-control study.” Phlebology (2026). PMID: 41489509 ↗

    L3bCASE_CONTROLCited in: History and Physical Examination
  113. [113]

    Zhao Y, Zhou T, Fang Q et al.. “Short-term outcomes after hybrid unicompartmental knee arthroplasty: A retrospective cohort study with minimum 3-year follow-up.” Medicine (2026). PMID: 41861224 ↗

    L2bCOHORTCited in: History and Physical Examination, Diagnosis and Workup
  114. [114]

    Benseler A, Gien LT, Swift B et al.. “Association of body mass index and length of stay in patients undergoing minimally invasive surgery for uterine cancer: a National Surgical Quality Improvement Program (NSQIP) study.” International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2026). PMID: 41774951 ↗

    L5OTHERCited in: History and Physical Examination, Diagnosis and Workup, Special Populations
  115. [115]

    Kulachote N, Phoophiboon P, Chanplakorn P et al.. “Risk Factors for Preoperative DVT in Elderly Patients with Hip Fractures.” Journal of clinical medicine (2026). PMID: 41753171 ↗

    L5OTHERCited in: History and Physical Examination
  116. [116]

    Fu C, Chen J, Shen Z et al.. “Plasma Protein Mediation of the Association Between Blood Pressure and Retinal Vascular Occlusion.” Translational vision science & technology (2025). PMID: 41324311 ↗

    L5OTHERCited in: History and Physical Examination
  117. [117]

    Smadi Z, Lingam S, Muwalla R et al.. “Weight on the fixation: the influence of body mass index on lower extremity fracture fixation outcomes.” Injury (2025). PMID: 41197500 ↗

    L5OTHERCited in: History and Physical Examination
  118. [118]

    Xu JJ, Johnson MC, Lama G et al.. “The Effect of Body Mass Index on the Efficacy of Semaglutide Use at the Time of Total Knee Arthroplasty.” The Journal of arthroplasty (2026). PMID: 41072554 ↗

    L5OTHERCited in: History and Physical Examination
  119. [119]

    Akar B, Oztürkmen Y, Balioglu MB et al.. “The Effect of Obesity on Simultaneous Bilateral Knee Arthroplasty Surgery.” Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2025). PMID: 40981512 ↗

    L5OTHERCited in: History and Physical Examination
  120. [120]

    Hoedemakers T, van Hattum ES, Petri BJ et al.. “Upper extremity post-thrombotic syndrome score: consensus results from an international Delphi study.” Journal of thrombosis and haemostasis : JTH (2025). PMID: 40973017 ↗

    L5OTHERCited in: History and Physical Examination
  121. [121]

    O'Connor B, Meister K, Fellner A et al.. “Analyzing the Adequacy of BMI-Tiered Enoxaparin Dosing for Venous Thromboembolism Prophylaxis in the Bariatric Surgery Population Based on Anti-Factor Xa Assay Data.” Obesity surgery (2025). PMID: 40615759 ↗

    L5OTHERCited in: History and Physical Examination
  122. [122]

    Canas A, Epstein J, Chen T et al.. “Diagnosis of Venous Thromboembolism.” The Medical clinics of North America (2025). PMID: 40500082 ↗

    L5REVIEW_NARRATIVECited in: History and Physical Examination
  123. [123]

    Jin C, Hu Y, Liu F. “Clinical characteristics, clinical laboratories, and risk factors of elderly patients with chronic obstructive pulmonary disease complicated with pulmonary embolism.” Frontiers in medicine (2025). PMID: 40438367 ↗

    L5OTHERCited in: History and Physical Examination
  124. [124]

    Kumar S, Nasef H, Yates Z et al.. “Association of Body Mass Index With Severe Sepsis Outcomes in Critically-Ill Severely Injured Adult Trauma Patients: A National Analysis.” The Journal of surgical research (2025). PMID: 40378666 ↗

    L5OTHERCited in: History and Physical Examination
  125. [125]

    Cherkaoui M, Al-Attabi M, Salimi S et al.. “Proximal venous ultrasound with risk stratification safely excludes deep venous thrombosis in emergency department routine care: an observational study.” Scandinavian journal of trauma, resuscitation and emergency medicine (2025). PMID: 40369661 ↗

    L5OTHERCited in: History and Physical Examination
  126. [126]

    Masuda Y, Konishi T, Yakushijin Y et al.. “Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis.” International journal of clinical oncology (2025). PMID: 40355784 ↗

    L5OTHERCited in: History and Physical Examination
  127. [127]

    Daher M, Liu J, Smith N et al.. “Short-term outcomes of outpatient total joint arthroplasty in morbidly obese patients.” European journal of orthopaedic surgery & traumatology : orthopedie traumatologie (2025). PMID: 40349255 ↗

    L5OTHERCited in: History and Physical Examination
  128. [128]

    Waseem MH, Abideen ZU, Rissardo JP et al.. “Comparing Efficacy and Safety of Different Anticoagulants in Cerebral Venous Thrombosis: A Systematic Review and Network Meta-Analysis.” Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2026). PMID: 41773593 ↗

    L2aSR_OBSCited in: Diagnosis and Workup
  129. [129]

    Schmidt C, Papo M, Taïeb D et al.. “Severe thrombocytopenia in antiphospholipid syndrome: a retrospective study of 432 patients.” RMD open (2026). PMID: 41956709 ↗

    L2bCOHORTCited in: Diagnosis and Workup, Special Populations
  130. [130]

    Huang J, Lin P, Wang L et al.. “Case Report: Primary vascular sarcoma presenting as massive pulmonary embolism salvaged by veno-arterial extracorporeal membrane oxygenation and interventional therapy.” Frontiers in cardiovascular medicine (2026). PMID: 41940087 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup
  131. [131]

    Mo R, Yu S, Xu H et al.. “Upadacitinib in refractory ulcerative colitis patients with high thromboembolic risk: two case reports.” Frontiers in immunology (2026). PMID: 41853288 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup
  132. [132]

    Hu H, Cai D, Li J et al.. “Pulmonary infection by Nocardia saintgeorgesii mimicking lung cancer with concurrent pulmonary embolism in an immunocompetent host: a case highlighting the diagnostic role of mNGS.” Frontiers in cellular and infection microbiology (2026). PMID: 41822328 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup, Differential Diagnosis, Special Populations
  133. [133]

    Xu C, Annapureddy H, Carson L et al.. “Impact of a factor Xa inhibitor (apixaban) on SIV pathogenesis and response to antiretroviral therapy.” JCI insight (2026). PMID: 41948932 ↗

    L5OTHERCited in: Diagnosis and Workup
  134. [134]

    Mukund A, Thakur V, Jindal A et al.. “Long-Term Efficacy and Outcomes of Endovascular Interventions in Budd-Chiari Syndrome-A Real World Analysis.” Liver international : official journal of the International Association for the Study of the Liver (2026). PMID: 41947698 ↗

    L5OTHERCited in: Diagnosis and Workup
  135. [135]

    Terao R, Fujino R, Hayashi K et al.. “Role of Autotaxin in the Pathogenesis of Retina Ischemia and Its Therapeutic Implications.” International journal of molecular sciences (2026). PMID: 41898636 ↗

    L5OTHERCited in: Diagnosis and Workup
  136. [136]

    Deng Y, Liu Y, Li X et al.. “Delayed anti-vascular endothelial growth factor therapy in patients with type 2 diabetes mellitus and branch retinal vein occlusion-associated macular edema negatively affects visual outcomes.” Frontiers in endocrinology (2026). PMID: 41884213 ↗

    L5OTHERCited in: Diagnosis and Workup
  137. [137]

    Zhan J, Qiao D, Sun G et al.. “Geometric Decomposition of OCT Angiography in RVO: Unmasking Congestive Versus Compensatory Phenotypes and Deep Retina-Choroid Coupling.” Translational vision science & technology (2026). PMID: 41873904 ↗

    L5OTHERCited in: Diagnosis and Workup
  138. [138]

    Jia J, Ning C, Wang Q et al.. “Stereotactic body radiotherapy plus lenvatinib and sintilimab with and without transarterial embolization for advanced hepatocellular carcinoma with portal vein tumor thrombus: a dual-center, propensity score-matched retrospective analysis.” Frontiers in immunology (2026). PMID: 41859127 ↗

    L5OTHERCited in: Diagnosis and Workup, Special Populations
  139. [139]

    Iby J, Kreminger J, Stino H et al.. “Retinal Characteristics in Eyes With Retinal Vein Occlusion Using Widefield Swept-Source Optical Coherence Tomography Angiography.” Investigative ophthalmology & visual science (2026). PMID: 41854209 ↗

    L5OTHERCited in: Diagnosis and Workup
  140. [140]

    Hofstetter RV, Marx CE, Kraaijpoel N et al.. “Reporting of D-dimer testing in venous thromboembolism diagnostic management studies: a scoping review.” Journal of thrombosis and haemostasis : JTH (2026). PMID: 41839295 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  141. [141]

    Cun D, Li J, He P et al.. “Preoperative deep vein thrombosis in tibial plateau fractures: development and internal validation of an interpretable multivariable machine-learning diagnostic model.” Frontiers in medicine (2026). PMID: 41767515 ↗

    L5OTHERCited in: Diagnosis and Workup
  142. [142]

    Wu CL, Lu JW, Ho YJ et al.. “Deep Immunophenotyping Reveals a Resilient Tph-ABC Axis in Difficult-to-treat Rheumatoid Arthritis: A Case Report of JAK Inhibitor Failure Complicated by Herpes Zoster and Thrombosis.” In vivo (Athens, Greece) (2026). PMID: 41760293 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup
  143. [143]

    Ezeh UC, Tesema N, Hasnie S et al.. “Isolated external jugular thrombophlebitis secondary to acute pharyngitis: a case report and a review of the literature.” Italian journal of pediatrics (2024). PMID: 39285285 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  144. [144]

    Knight GM, Desai KR. “Team-based approach to deep venous disease: A multidisciplinary approach to the multifaceted problem of thrombotic lower extremity venous disease.” Seminars in vascular surgery (2025). PMID: 41386912 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  145. [145]

    Phuyal D, Abbas F, Darras O et al.. “Evaluating the Safety of Immediate Lymphatic Reconstruction With Implant-Based Breast Reconstruction: Eight-Year Institutional Review.” Microsurgery (2025). PMID: 40956145 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  146. [146]

    Hassanzadeh S, Lakhman Y, Sadowski EA et al.. “Abdominopelvic complications of gynecologic malignancy: Essentials for radiologists.” European journal of radiology (2025). PMID: 40753689 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  147. [147]

    Hurst M, Shin L. “Charcot neuroarthropathy: Surgical and conservative treatment approaches.” Seminars in vascular surgery (2025). PMID: 40086925 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  148. [148]

    Wen X, Wu Z. “A retrospective study on the diagnostic value of ultrasonography for primary vascular leiomyosarcoma misdiagnosed as deep vein thrombosis.” Phlebology (2026). PMID: 40454675 ↗

    L2bCOHORTCited in: Differential Diagnosis
  149. [149]

    Mitchell S, Rojas OG, Mathavan A et al.. “A 36-Year-Old Man With Hemoptysis and Fevers.” Chest (2026). PMID: 41672657 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  150. [150]

    Lesage L, Barral PA, Chew A et al.. “Streptococcus constellatus-associated Lemierre syndrome complicated by pulmonary artery pseudoaneurysm in an 11-year-old girl.” Pediatric radiology (2026). PMID: 41511544 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  151. [151]

    Ossuna M, Hamamoto Filho PT, Zanini MA. “Spontaneous thrombosis of drainage vein in cavernoma-associated developmental venous anomaly.” Neuroradiology (2025). PMID: 41065868 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  152. [152]

    DSouza R, Kuruvilla Thomas S, Patharateeranart K et al.. “Pseudo hepatic vein thrombosis in a newborn with infracardiac total anomalous pulmonary venous connection.” Pediatric radiology (2024). PMID: 39485501 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  153. [153]

    Godoy IRB, Cantarelli Rodrigues T, Alharfi M et al.. “Imaging in the diagnosis and characterization of tennis leg.” Skeletal radiology (2026). PMID: 41981329 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  154. [154]

    Embaby O, Bin Asmadi A, Binte Asmadi A et al.. “PATHOGENESIS OF ACUTE DIABETIC CHARCOT ARTHROPATHY IN THE FOOT AND ANKLE: A COMPREHENSIVE LITERATURE REVIEW.” Orthopedic reviews (2025). PMID: 40969400 ↗

    L5REVIEW_NARRATIVECited in: Differential Diagnosis
  155. [155]

    Jang E, Moon KY, Park SC et al.. “Primary leiomyosarcoma originating from the deep femoral vein initially presenting as chronic deep vein thrombosis: A case report and review of literature.” Medicine (2026). PMID: 41961719 ↗

    L4CASE_REPORTCited in: Differential Diagnosis, Special Populations
  156. [156]

    Cheng L, Li L. “Tumor-like cortical venous thrombosis: Case report and literature review.” Medicine (2026). PMID: 41766497 ↗

    L4CASE_REPORTCited in: Differential Diagnosis, Special Populations
  157. [157]

    Ak S, Thomas-Ogunniyi J, Takei H. “Intravascular Fasciitis Mimicking Deep Vein Thrombosis with Pulmonary Embolism in May-Thurner Syndrome: First Reported Case with Literature Review.” Annals of clinical and laboratory science (2025). PMID: 40962462 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  158. [158]

    Teshima R, Saito-Sasaki N, Sawada Y. “Age as a key risk factor for deep vein thrombosis in patients with lower limb cellulitis.” Frontiers in medicine (2025). PMID: 40620438 ↗

    L5OTHERCited in: Differential Diagnosis
  159. [159]

    Cleary CM, Orosco E, Gallagher J et al.. “Continuation of anticoagulation through ambulatory phlebectomy does not impact postoperative bleeding risk.” Journal of vascular surgery. Venous and lymphatic disorders (2025). PMID: 39890080 ↗

    L5OTHERCited in: Differential Diagnosis
  160. [160]

    Awashra A, Salameh AA, Milhem F et al.. “Right atrial thrombus mimicking cardiac myxoma: surgical and postoperative management.” Journal of cardiothoracic surgery (2025). PMID: 41422031 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  161. [161]

    Phillips I, Chen J, Milhem M et al.. “Vascular Leiomyosarcoma Masquerading as Chronic Deep Venous Thrombosis.” Clinical nuclear medicine (2026). PMID: 41380714 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  162. [162]

    Romano A, Kaisari E, Belkoniene M et al.. “A case of paracentral acute middle maculopathy and retinal vein occlusion: idiopathic occlusive retinal vasculitis or incomplete Behçet's disease?” BMC ophthalmology (2025). PMID: 41088010 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  163. [163]

    Bass R, Mitta P, Burgan C et al.. “Intravascular organizing thrombus in the forearm: a unique imaging presentation.” Skeletal radiology (2026). PMID: 41068310 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  164. [164]

    Tse JD, Laller S, Kharait S. “Case Report: Steroids for diabetic myonecrosis in ESKD: an unconventional treatment with unexpected success.” Frontiers in nephrology (2025). PMID: 40963896 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  165. [165]

    Al-Akhali ES, Alshoabi SA, Muslem HF et al.. “Multisystemic Tuberculosis Masquerading as Aggressive Cardiac Tumor Causing Budd-Chiari Syndrome Disseminated to the Brain Resulting in Death of a Six-Year-Old Boy.” Pathogens (Basel, Switzerland) (2025). PMID: 40872282 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  166. [166]

    Okumura M, Sakuta K, Gomi T et al.. “Atypical intracerebral hemorrhage and internal jugular vein thrombosis in meningovascular neurosyphilis.” Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2025). PMID: 40633667 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  167. [167]

    Erb BM, Jeffrey JH, Reed DS et al.. “MRSA Cellulitis with Orbital and Retinal Abscesses Resulting in Lemierre Syndrome Following Eyebrow Piercing.” Ophthalmic plastic and reconstructive surgery (Unknown). PMID: 39718131 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  168. [168]

    Reich T, Blum B, Zimmerli L. “[The slightly different neck pain].” Praxis (2026). PMID: 41784513 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  169. [169]

    Gietzelt C, Wiedemann J, Lappas A et al.. “[Thrombosis of the superior ophthalmic vein-A case series and review of the literature].” Die Ophthalmologie (2024). PMID: 39266751 ↗

    L4CASE_REPORTCited in: Differential Diagnosis
  170. [170]

    Duan H, Jiang C, Zhang B et al.. “Risk of Malignancies and Major Adverse Cardiovascular Events Related to JAK Inhibitors in Rheumatoid Arthritis: A Meta-Analysis.” Clinical pharmacology and therapeutics (2026). PMID: 41427516 ↗

    L2aSR_OBSCited in: Special Populations
  171. [171]

    Chen K, Zhuo L, Liu Z et al.. “Presurgical molecular therapy for renal cell carcinoma with venous tumor thrombus: a systematic review and meta-analysis.” Frontiers in immunology (2025). PMID: 41394875 ↗

    L2aSR_OBSCited in: Special Populations
  172. [172]

    Willems RAL, van Diepen AE, Dekker EN et al.. “Thromboembolic Events During Perioperative Therapy for Resectable and Borderline Resectable Pancreatic Cancer in the PREOPANC-2 Trial.” Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2026). PMID: 41610374 ↗

    L1bRCTCited in: Special Populations
  173. [173]

    Mahé I, Chapelle C, Girard P et al.. “Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated venous thromboembolism (API-CAT): a post-hoc analysis of a randomised, non-inferiority trial.” The Lancet. Haematology (2026). PMID: 41365312 ↗

    L1bRCTCited in: Special Populations
  174. [174]

    Mo N, Hu K, Zeng Z et al.. “Stereotactic body radiation therapy combined with cadonilimab and lenvatinib in the treatment of hepatocellular carcinoma with Vp3 or Vp4 portal vein tumor thrombus: a prospective, multicenter, single-arm, phase II clinical trial.” Frontiers in immunology (2025). PMID: 41293180 ↗

    L2bTRIAL_NONRANDOMCited in: Special Populations
  175. [175]

    Tong CX, Ma R, Meng T. “Left ovarian vein thrombosis suspected during cesarean section and confirmed postoperatively: a case report and review of the literature.” BMC pregnancy and childbirth (2026). PMID: 41688956 ↗

    L4CASE_REPORTCited in: Special Populations
  176. [176]

    Yaqian Y, Chuanliang Z, Guowei Z et al.. “Efficacy of Z-shaped supine position in robot-assisted radical prostatectomy: study protocol for a randomized controlled trial.” Trials (2026). PMID: 41588472 ↗

    L2bTRIAL_NONRANDOMCited in: Special Populations
  177. [177]

    Jian H, Cui X, Dou Y et al.. “Adoption of plasma D-dimer testing, color Doppler ultrasound, and enoxaparin sodium in predicting and preventing lower extremity deep vein thrombosis in high-risk parturients undergoing cesarean section.” Medicine (2025). PMID: 41398758 ↗

    L1bRCTCited in: Special Populations
  178. [178]

    Federspiel JJ, Rodger MA, Hoffman MR et al.. “Postoperative venous thromboembolism following cesarean delivery: prevalence, pathophysiology, diagnosis, treatment, and prevention.” American journal of obstetrics and gynecology (2026). PMID: 41485833 ↗

    L5REVIEW_NARRATIVECited in: Special Populations
  179. [179]

    Ma J, Ke X, Zhu D. “The effect of anticoagulants on preventing venous thromboembolism in cancer patients: A systematic review and meta-analysis.” The National medical journal of India (2025). PMID: 41645951 ↗

    L2aSR_OBSCited in: Special Populations
  180. [180]

    Wardhana DPW, Soetomo CT, Satyarsa ABS et al.. “Critical shift phase in deep vein thrombosis development after major sellar region tumor surgeries: a systematic review.” Annals of medicine (2025). PMID: 41392925 ↗

    L2aSR_OBSCited in: Special Populations
  181. [181]

    Chiu YC, Chang WC, Chiu YC. “Early catheter-directed portal vein thrombolysis in myeloproliferative disorder-related diffuse mesenteric venous ischemia: A case report.” World journal of gastroenterology (2026). PMID: 41640868 ↗

    L4CASE_REPORTCited in: Special Populations
  182. [182]

    Darby A, Bocchicchio M, Tabatabai R. “Cerebral Venous Thrombosis.” Emergency medicine clinics of North America (2026). PMID: 41260855 ↗

    L5REVIEW_NARRATIVECited in: Special Populations
  183. [183]

    Guo B, Yerken S, Luo C et al.. “Liver resection versus transarterial chemoembolization plus PD-1 inhibitors and lenvatinib for hepatocellular carcinoma with portal vein tumour thrombus.” BJS open (2025). PMID: 41871372 ↗

    L5OTHERCited in: Special Populations
  184. [184]

    Wang L, Feng JK, Zhou B et al.. “Optimal duration of adjuvant targeted-immunotherapy in patients with initially unresectable hepatocellular carcinoma with portal vein tumor thrombus following successful conversion therapy.” The oncologist (2026). PMID: 41723827 ↗

    L5OTHERCited in: Special Populations
  185. [185]

    Xie R, Lu M, Wu J et al.. “Renal Pelvic Urothelial Carcinoma With Venous Tumor Thrombus: Prognosis and Reconsideration of TNM Staging.” Clinical genitourinary cancer (2026). PMID: 41680068 ↗

    L5OTHERCited in: Special Populations
  186. [186]

    Mohan N, Srivastava SK, Duphare C et al.. “Risk of retinal vein occlusions in patients taking systemic tyrosine kinase inhibitors.” Eye (London, England) (2026). PMID: 41652018 ↗

    L5OTHERCited in: Special Populations
  187. [187]

    Kurita D, Miyamoto S, Saito Y et al.. “Prevalence of Subclinical Internal Jugular Vein Thrombosis After Microvascular Head and Neck Reconstruction.” Microsurgery (2026). PMID: 41575013 ↗

    L5OTHERCited in: Special Populations
  188. [188]

    Zhou B, Ma Z, Wang L et al.. “Real-world outcomes of stereotactic body radiotherapy plus sintilimab and bevacizumab for hepatocellular carcinoma with portal vein tumor thrombus.” The oncologist (2026). PMID: 41495001 ↗

    L5OTHERCited in: Special Populations
  189. [189]

    Cui S, Wang D, Lyu S et al.. “Organ-specific role of neutrophil extracellular traps in shaping the postoperative thrombo-inflammatory niche in pancreatic ductal adenocarcinoma: a multi-model machine learning and mechanistic study.” Frontiers in immunology (2025). PMID: 41445740 ↗

    L5OTHERCited in: Special Populations

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