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Nephrology›Condition·Updated Jul 11, 2026·v1

Acute Kidney Injury

Acute kidney injury is a common, high-mortality syndrome defined by KDIGO criteria (SCr rise ≥0.3 mg/dL in 48 h, ≥1.5× baseline in 7 d, or UO <0.5 mL/kg/h for ≥6 h). Management focuses on hemodynamic optimization with balanced crystalloids, avoidance of nephrotoxins, electrolyte correction, and delayed initiation of RRT (safe in ~40% of patients). Long-term, all survivors require structured nephroprotection with RAS blockade and SGLT2 inhibitors to prevent CKD progression.

High Evidence647 references·11,857 words·48 min read·v1
Acute Kidney InjuryNephrologyAcute Renal FailureKDIGORenal Replacement TherapyAcute Tubular NecrosisSepsis-Associated AKIContrast NephropathyDrug-Induced Nephritis

Quick Reference

RxDrug of choiceFor acute volume resuscitation: balanced crystalloids (lactated Ringer's, Plasma-Lyte). For life-threatening hyperkalemia: calcium gluconate 1 g IV + insulin 10 U + dextrose 25 g IV + albuterol 10-20 mg. For long-term nephroprotection: [[ACE inhibitor]]/[[ARB]] (lisinopril 5-40 mg/day or losartan 25-100 mg/day) + [[SGLT2 inhibitor]] ([[empagliflozin]] 10 mg/day or [[dapagliflozin]] 10 mg/day) ± [[finerenone]] 10-20 mg/day in diabetic CKD.
AltAlternativesFor RRT modality: CRRT for shock, IHD for stable patients, PD for low-resource settings. For ICI-AKI: prednisone 0.5-1 mg/kg/day. For metabolic acidosis: sodium bicarbonate 50-100 mEq (reserved for pH<7.0 or AKIN 2-3). For sedation in S-AKI: consider dexmedetomidine.
⊘AvoidHydroxyethyl starches, NSAIDs (in CKD or volume depletion), iodinated contrast without appropriate prophylaxis, ACEi/ARB during acute hemodynamic instability, non-dihydropyridine CCBs (verapamil, diltiazem) in heart failure with AKI, and routine loop diuretics without fluid overload.
DxTest of choiceUrine microscopy with sediment examination (muddy brown granular casts for ATN, dysmorphic RBCs for GN) and renal ultrasound to exclude obstruction. FENa (or FEUrea if on diuretics) to differentiate prerenal vs intrinsic.
ScKey scoreKDIGO staging (creatinine and urine output). Mehran risk score for contrast-associated AKI. SPARK index for postoperative AKI.
→When to referAKI Stage ≥2, need for RRT, uncertain etiology, suspected glomerulonephritis or systemic vasculitis, AKI not improving after 1-2 weeks, all AKI survivors for structured post-discharge follow-up.
AKI is a high-mortality syndrome affecting >10% of inpatients. Diagnose with KDIGO criteria; manage with balanced crystalloids, avoidance of nephrotoxins, electrolyte correction, and delayed RRT strategy (start for AEIOU criteria or oliguria >72h). Long-term, all survivors require RAS blockade + SGLT2i ± finerenone to prevent CKD progression.
Acute kidney injury (AKI) is an abrupt decline in kidney function defined by the [[KDIGO]] criteria: serum creatinine rise ≥0.3 mg/dL within 48 hours, ≥1.5× baseline within 7 days, or urine output <0.5 mL/kg/h for ≥6 hours. AKI affects 10-15 % of hospitalized patients and >50 % of ICU patients; even Stage 1 independently doubles short-term mortality. Early detection, structured hemodynamic optimization, avoidance of nephrotoxins, and judicious use of renal replacement therapy (delayed strategy preferred) reduce morbidity. Long-term, all survivors require nephroprotection with RAS blockade, SGLT2 inhibitors, and risk-factor modification to prevent chronic kidney disease progression.

Overview and Recommendations

Background

  • •Acute kidney injury (AKI) is a clinical syndrome defined by an abrupt decline in excretory function, quantified by the 2012 criteria: a rise in serum creatinine (SCr) ≥0.3 mg/dL within 48 hours, an increase ≥1.5× baseline within 7 days, or a fall in urine output (UO) <0.5 mL/kg/h for ≥6 hours. Three severity stages exist, with Stage 1 representing the threshold and Stage 3 representing a ≥200 % SCr rise or initiation of renal replacement therapy (RRT). The pathophysiology is categorized into prerenal (renal hypoperfusion with intact parenchyma), intrinsic renal (direct injury to tubules, glomeruli, interstitium, or vasculature), and postrenal (urinary tract obstruction).
  • •AKI is a global public health priority. It affects approximately 10-15 % of all hospitalized patients and over 50 % of ICU patients, with 1-2 million hospitalizations annually in China alone. Even Stage 1 AKI independently doubles short-term mortality. Survivors face a significantly increased risk of chronic kidney disease (CKD; HR 2.67), end-stage kidney disease (HR 4.81), and death (HR 1.80). The syndrome is not self-limited, maladaptive repair drives fibrosis and the AKI-to-CKD transition, making structured follow-up mandatory.
  • •The most common intrinsic form is (ATN), often due to ischemia, sepsis, or nephrotoxins. Sepsis-associated AKI (S-AKI) is the leading cause in critical illness, involving microvascular dysfunction, inflammation, and metabolic reprogramming. Drug-induced AKI is frequent, especially from combinations like plus , , aminoglycosides, and iodinated contrast. Postrenal AKI (5-10 % of cases) is usually reversible if obstruction is relieved within 24-48 hours.
  • •The pathogenesis converges on mitochondrial failure, cell death (ferroptosis, apoptosis, necroptosis), and dysregulated inflammation. In ischemia-reperfusion, proximal tubular cells shift to anaerobic metabolism, ATP depletion disables ion pumps, and reperfusion generates reactive oxygen species that trigger ferroptosis. In S-AKI, preserved global renal blood flow coexists with microvascular shunting and metabolic reprogramming. Maladaptive repair, G2/M cell-cycle arrest in tubular cells, promotes a pro-fibrotic secretory phenotype (TGF-β, CTGF), pericyte-to-myofibroblast transition, and interstitial fibrosis.
  • •Key susceptibility factors include pre-existing CKD (HR 8.8 for CKD after AKI), diabetes (HR 1.49), hypertension, aging, and nephrotoxic drug combinations. Avoidance of nephrotoxic pairs (e.g., vancomycin + piperacillin-tazobactam) and hemodynamic optimization are the most effective prevention strategies. The Four Pillars of long-term nephroprotection, RAS blockade, SGLT2 inhibitors, nonsteroidal MRAs, and GLP-1 receptor agonists, have replaced the legacy approach of watching and waiting.

Evaluation

  • •Suspect AKI in any hospitalized patient with oliguria (UO <0.5 mL/kg/h for ≥6 hours), unexplained rise in SCr, or predisposing conditions (sepsis, surgery, contrast exposure, nephrotoxic medications). Confirm AKI using criteria: SCr increase ≥0.3 mg/dL within 48 hours, ≥1.5× baseline within 7 days, or UO <0.5 mL/kg/h for ≥6 hours.
  • •Ask about symptoms: reduced urine volume (oliguria or anuria), foamy or tea-colored urine (suggests glomerulonephritis), dark brown urine (suggests pigment nephropathy from or hemolysis), flank or suprapubic pain (obstruction), and constitutional symptoms (fatigue, anorexia, nausea). Probe for fever, rash, arthralgias (acute interstitial nephritis) and review all medications: NSAIDs, ± , proton pump inhibitors, contrast, herbal remedies.
  • •Examine volume status: orthostatic hypotension indicates prerenal cause; peripheral edema and jugular venous distention suggest volume overload from intrinsic AKI or heart failure; palpable bladder suggests obstruction. Look for asterixis (liver flap) as a sign of uremia. Assess respiratory rate and oxygen saturation for pulmonary edema.
  • •Order a renal ultrasound immediately to exclude obstructive uropathy, hydronephrosis, stones, or masses. In critically ill patients, point-of-care ultrasound also assesses volume status and cardiac function. Avoid contrast-enhanced studies unless absolutely indicated.
  • •Perform urine microscopy on a fresh, clean-catch sample. Muddy brown granular casts and renal tubular epithelial cell casts are pathognomonic for (ATN). White blood cell casts and eosinophiluria suggest acute interstitial nephritis (AIN). Dysmorphic red blood cells and red cell casts indicate glomerulonephritis. Acellular sediment with hyaline casts suggests prerenal azotemia.
  • •Calculate the fractional excretion of sodium (FENa): FENa = (U[Na] × P[Cr]) / (P[Na] × U[Cr]) × 100. FENa <1 % has 90 % sensitivity and 82 % specificity for prerenal AKI. FENa >2 % suggests intrinsic ATN. In patients on diuretics, use FEUrea <35 % for prerenal (less affected by loop diuretics).
  • •Order serum chemistry: SCr, BUN, electrolytes (K+, Na+, Cl-, HCO3-), calcium, phosphate, uric acid, creatine kinase (if rhabdomyolysis suspected). Complete blood count with smear to look for schistocytes (thrombotic microangiopathy). Check LDH, haptoglobin, and ADAMTS13 if TMA is considered.
  • •Consider novel biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin C can detect tubular injury earlier than creatinine, but they are not yet incorporated into standard diagnostic criteria. Cystatin C-based eGFR may identify occult kidney dysfunction (eGFRcys >27 % lower than eGFRcr confers HR 2.6 for subsequent AKI).
  • •If cause remains unclear after urine sediment and FENa, order serologies: complement C3/C4, ANA, ANCA, anti-GBM, anti-streptolysin O, hepatitis B and C, HIV, serum and urine protein electrophoresis with free light chains, and cryoglobulins.
  • •Perform a renal biopsy if the cause remains uncertain, if glomerulonephritis or systemic vasculitis is suspected, or if AKI does not improve after 1-2 weeks of supportive care. Biopsy distinguishes ATN (tubular injury), AIN (interstitial inflammation), glomerulonephritis (crescents, endocapillary proliferation), TMA, or crystal nephropathy.
  • •Use validated risk scores for specific settings: the Mehran score for contrast-associated AKI after PCI (AUC ≈0.80); the SPARK index for postoperative AKI in noncardiac surgery (c-statistic 0.80). Machine-learning models show higher discrimination (pooled AUC 0.82) but are not yet widely implemented.
  • •Identify red flags requiring urgent RRT evaluation: respiratory distress with SpO₂ <90 % despite high-flow oxygen (consider intubation if FVC <15 mL/kg), hyperkalemia >6.5 mmol/L with ECG changes (peaked T waves, widened QRS), severe metabolic acidosis pH <7.15, uremic pericarditis (pericardial rub, chest pain), rapidly rising creatinine >3 mg/dL over 24-48 hours, or anuria >12 hours.

Management

  • •Initiate hemodynamic optimization: correct hypovolemia with balanced crystalloids ( or Plasma-Lyte) rather than 0.9 % saline to reduce the risk of hyperchloremic metabolic acidosis and subsequent AKI. Avoid hydroxyethyl starches, they increase AKI and RRT need.
  • •Once euvolemia is achieved, restrict daily fluid balance to ≤0.5 L positive after the first 24-48 hours. Use 20-80 mg IV (or continuous infusion 5-20 mg/h) only for pulmonary edema, do NOT use diuretics to convert oliguric to non-oliguric AKI. Early diuretic use in Stage 3 AKI is associated with higher mortality (HR 1.42).
  • •Manage life-threatening hyperkalemia (K⁺ >6.5 mmol/L or with ECG changes): immediately administer calcium gluconate 1 g IV over 2-3 minutes for cardiac membrane stabilization. Then give regular insulin 10 U IV plus 50 mL of 50 % dextrose, followed by nebulized albuterol 10-20 mg. Consider sodium bicarbonate 50 mEq IV if metabolic acidosis coexists. Monitor blood glucose hourly.
  • •For severe metabolic acidosis (pH <7.15-7.20): administer IV sodium bicarbonate 1-2 ampules (50-100 mEq) over 30-60 minutes, but reserve for pH <7.0 or for AKI Stage 2-3 (BICAR-ICU subgroup benefit). Routine bicarbonate use does not improve survival and may worsen intracellular acidosis.
  • •Discontinue all nephrotoxic medications: NSAIDs, aminoglycosides, IV contrast (if feasible), ACE inhibitors/ARBs during hemodynamic instability, and proton pump inhibitors (risk of AIN). Dose-adjust all renally cleared drugs to estimated GFR.
  • •For sepsis-associated AKI, follow Surviving Sepsis guidelines: early broad-spectrum antibiotics, norepinephrine as first-line vasopressor, and goal-directed resuscitation. Consider as the preferred sedative, a meta-analysis found it significantly reduced AKI incidence (P=0.004) compared with other sedatives.
  • •Initiate renal replacement therapy (RRT) emergently if any AEIOU criterion is present: Acidosis (pH <7.15 refractory), Electrolyte disturbance (K⁺ >6.5 refractory), Intoxication (dialyzable toxin), Overload (diuretic-resistant pulmonary edema), Uremia (pericarditis, encephalopathy, or bleeding).
  • •If no AEIOU criteria, adopt a delayed RRT strategy: monitor kidney function and volume status; initiate RRT if oliguria persists >72 hours or BUN exceeds 112 mg/dL. This approach avoids RRT in ~40 % of patients without increasing mortality (STARRT-AKI, AKIKI). Do NOT initiate RRT early without indications, accelerated strategies increase RRT dependence at 90 days (10.4 % vs 6.0 %). Do NOT delay beyond BUN >140 mg/dL (AKIKI 2 showed harm).
  • •Choose RRT modality based on hemodynamic stability: continuous RRT (CRRT) for unstable patients; intermittent hemodialysis (IHD) for stable patients; peritoneal dialysis in resource-limited settings. Deliver a dose of 20-25 mL/kg/h, higher intensity does not improve survival. Anticoagulate with regional citrate for CRRT if feasible (longer filter life, potential survival benefit in S-AKI).
  • •After achieving hemodynamic stability and resolving acute phase, initiate long-term nephroprotection. Start an (e.g., lisinopril 5-10 mg daily) or (e.g., losartan 25-50 mg daily) in all AKI survivors with UACR ≥30 mg/g or hypertension. Titrate to maximally tolerated dose. Expect a small haemodynamic SCr rise (≤30 %), do not discontinue. Monitor K⁺ and Cr at 1-2 weeks.
  • •Add an once eGFR ≥20 mL/min/1.73 m²: 10 mg daily or 10 mg daily. This reduces kidney disease progression by 37 % and AKI by 23 % (meta-analysis). Continue until dialysis or transplant. No dose adjustment required.
  • •In patients with diabetic kidney disease (eGFR 30-90, UACR 100-5000), add 10-20 mg daily (nonsteroidal MRA). The CONFIDENCE trial showed that adding finerenone to empagliflozin plus RAS blockade reduced UACR by 29 % more than either agent alone. Monitor K⁺.
  • •Consider a (e.g., 0.6-1.8 mg SC daily) in patients with obesity or atherosclerotic cardiovascular disease and persistent albuminuria despite RAS blockade, SGLT2i, and finerenone. Liraglutide reduced the composite renal outcome by 22 % (LEADER trial).
  • •For immune checkpoint inhibitor-associated AKI (ICI-AKI): hold the ICI, discontinue PPI/NSAIDs, and start 0.5-1 mg/kg/day tapered over 4-6 weeks. Renal recovery occurs in ~85 % of treated patients. Rechallenge with ICI after resolution is feasible but carries a 23 % risk of recurrence.
  • •Refer to nephrology for: AKI Stage ≥2, need for RRT, uncertain etiology, suspected glomerulonephritis or systemic vasculitis, AKI not improving after 1-2 weeks of supportive care, and all AKI survivors for post-discharge follow-up within 30 days (associated with improved survival).
  • •At discharge, measure eGFR and UACR at 3 months, then at least annually. Educate patients to avoid over-the-counter NSAIDs when febrile or volume-depleted, maintain hydration during intercurrent illness, and seek medical attention for oliguria or weight gain. Aggressively control blood pressure to <120 mmHg in high-risk patients (SPRINT).
  • •For acute tubulointerstitial nephritis (drug-induced, non-ICI): remove the offending drug. Consider prednisone 0.5-1 mg/kg/day started within 7 days of diagnosis to improve renal recovery. For lupus nephritis, use induction with or plus corticosteroids.
  • •Do NOT give routine iron chelation or mesenchymal stem cells for AKI, phase 2 trials showed no benefit. Do NOT restrict protein intake to <0.8 g/kg/day in the post-AKI period, higher protein (≥2.2 g/kg/day) in critically ill patients with AKI worsened outcomes. Do NOT use isotonic sodium bicarbonate or acetylcysteine for contrast-AKI prevention (PRESERVE trial showed no benefit).

Board Review — High Yield

  • •Muddy brown granular casts, Pathognomonic for acute tubular necrosis on urine sediment.
  • •FENa <1%, Indicates prerenal AKI (sensitivity 90%, specificity 82%). Use FEUrea <35% if patient on diuretics.
  • •KDIGO Stage 1, SCr rise ≥0.3 mg/dL in 48 h or ≥1.5× baseline in 7 d; independently doubles mortality.
  • •STARRT-AKI, Delayed RRT (wait for conventional indications or oliguria >72h) not inferior to early; ~40% avoid RRT.
  • •SGLT2 inhibitors, Reduce AKI risk by 23% and CKD progression by 37% (empagliflozin 10 mg, dapagliflozin 10 mg).
  • •Hyperkalemia management, Calcium gluconate (cardiac protection) → insulin+glucose → albuterol → consider bicarbonate.
  • •AEIOU mnemonic, Indications for emergent RRT: Acidosis, Electrolytes, Intoxication, Overload, Uremia.
  • •Balanced crystalloids preferred, 0.9% saline increases risk of hyperchloremic metabolic acidosis and AKI.
  • •BigpAK-2 trial, Biomarker-guided care bundle (hemodynamic monitoring, avoid nephrotoxins, normoglycemia) reduced moderate-to-severe AKI by 43% (NNT=12).
  • •PRESERVE trial, No benefit for sodium bicarbonate or acetylcysteine in preventing contrast-associated AKI.

Deep Dive — Evidence Details

References

  1. [1]

    Palevsky PM, Liu KD, Brophy PD et al.. “KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2013). PMID: 23499048 ↗

    L5GUIDELINECited in: Definition, Classification and Nomenclature, Staging and Risk Stratification (KDIGO), Acute Management
  2. [2]

    Thomas ME, Blaine C, Dawnay A et al.. “The definition of acute kidney injury and its use in practice.” Kidney international (2014). PMID: 25317932 ↗

    L5SR_OBSCited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae)
  3. [3]

    Ricci Z, Cruz D, Ronco C. “The RIFLE criteria and mortality in acute kidney injury: A systematic review.” Kidney international (2007). PMID: 18160961 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  4. [4]

    Yang C, Tonelli M, James MT et al.. “Incidence and Adverse Outcomes of Acute Kidney Disease: A Systematic Review and Meta-Analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 40609854 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  5. [5]

    Pickering JW, James MT, Palmer SC. “Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2014). PMID: 25445101 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  6. [6]

    Zhang Z, Lu B, Sheng X et al.. “Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2011). PMID: 21601330 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature, Prevention, Screening & Surveillance
  7. [7]

    Schmitt R, Coca S, Kanbay M et al.. “Recovery of kidney function after acute kidney injury in the elderly: a systematic review and meta-analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2008). PMID: 18511164 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  8. [8]

    Vlasschaert ME, Bejaimal SA, Hackam DG et al.. “Validity of administrative database coding for kidney disease: a systematic review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2011). PMID: 21184918 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  9. [9]

    Nigwekar SU, Kandula P, Hix JK et al.. “Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2009). PMID: 19406542 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  10. [10]

    Haase M, Bellomo R, Devarajan P et al.. “Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2009). PMID: 19850388 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  11. [11]

    Lu JC, Coca SG, Patel UD et al.. “Searching for genes that matter in acute kidney injury: a systematic review.” Clinical journal of the American Society of Nephrology : CJASN (2009). PMID: 19443624 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  12. [12]

    Nigwekar SU, Wolf M, Sterns RH et al.. “Calciphylaxis from nonuremic causes: a systematic review.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18417747 ↗

    L4SR_OBSCited in: Definition, Classification and Nomenclature
  13. [13]

    Barbar SD, Clere-Jehl R, Bourredjem A et al.. “Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis.” The New England journal of medicine (2018). PMID: 30304656 ↗

    L1RCTCited in: Definition, Classification and Nomenclature, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  14. [14]

    . “Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.” Lancet (London, England) (2022). PMID: 36351458 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature, Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  15. [15]

    Gaudry S, Hajage D, Benichou N et al.. “Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials.” Lancet (London, England) (2020). PMID: 32334654 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History, Special Populations & Pregnancy
  16. [16]

    Fiorentino M, Castellano G, Kellum JA. “Differences in acute kidney injury ascertainment for clinical and preclinical studies.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 28371878 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature, Clinical Presentation, Diagnosis and Workup
  17. [17]

    Leaf DE, Waikar SS. “End Points for Clinical Trials in Acute Kidney Injury.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2016). PMID: 27599630 ↗

    L5TRIAL_NONRANDOMCited in: Definition, Classification and Nomenclature
  18. [18]

    Lerink LJS, de Kok MJC, Mulvey JF et al.. “Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 34657378 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  19. [19]

    Peerapornratana S, Manrique-Caballero CL, Gómez H et al.. “Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment.” Kidney international (2019). PMID: 31443997 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prevention, Screening & Surveillance
  20. [20]

    Lameire NH, Levin A, Kellum JA et al.. “Harmonizing acute and chronic kidney disease definition and classification: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.” Kidney international (2021). PMID: 34252450 ↗

    L1OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management
  21. [21]

    Fouque D, Kalantar-Zadeh K, Kopple J et al.. “A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease.” Kidney international (2007). PMID: 18094682 ↗

    L1OTHERCited in: Definition, Classification and Nomenclature, Diagnosis and Workup, Staging and Risk Stratification (KDIGO)
  22. [22]

    Levey AS, Eckardt KU, Dorman NM et al.. “Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.” Kidney international (2020). PMID: 32409237 ↗

    L1OTHERCited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Prognosis and Natural History
  23. [23]

    Kavanagh D, Ardissino G, Brocklebank V et al.. “Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum.” Kidney international (2024). PMID: 39395628 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Diagnosis and Workup, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  24. [24]

    Kalim S, Rhee EP. “An overview of renal metabolomics.” Kidney international (2016). PMID: 27692817 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature
  25. [25]

    Himmelfarb J, Ikizler TA. “Acute kidney injury: changing lexicography, definitions, and epidemiology.” Kidney international (2007). PMID: 17396117 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, History and Evolution of Treatment
  26. [26]

    Rennie TJW, De Souza N, Donnan PT et al.. “Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2019). PMID: 29961876 ↗

    L4CASE_REPORTCited in: Definition, Classification and Nomenclature
  27. [27]

    Aderounmu T, Adeyemi B, Bolarinwa A. “Post-asphyxia acute kidney injury in neonates: a systematic review.” European journal of pediatrics (2026). PMID: 42096066 ↗

    L5SR_OBSCited in: Definition, Classification and Nomenclature
  28. [28]

    Rostami P, Jafari Rouhi A, Hajebrahimi R et al.. “Crush injury syndrome in earthquakes: a systematic review and meta-analysis on its frequency and complications.” BMC emergency medicine (2026). PMID: 41928063 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature
  29. [29]

    Zhang F, Wang H, Li J et al.. “Acute kidney injury incidence and mortality following spontaneous intracerebral hemorrhage: a systematic review and meta-analysis.” Frontiers in medicine (2026). PMID: 41907292 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature
  30. [30]

    Xu K, Rosenstiel P, Paragas N et al.. “Unique Transcriptional Programs Identify Subtypes of AKI.” Journal of the American Society of Nephrology : JASN (2016). PMID: 28028135 ↗

    L3OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors
  31. [31]

    Anderson S, Eldadah B, Halter JB et al.. “Acute kidney injury in older adults.” Journal of the American Society of Nephrology : JASN (2011). PMID: 21209252 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Prognosis and Natural History, Special Populations & Pregnancy
  32. [32]

    Basile DP, Bonventre JV, Mehta R et al.. “Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.” Journal of the American Society of Nephrology : JASN (2015). PMID: 26519085 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Long-term and Definitive Management, Prognosis and Natural History
  33. [33]

    Waikar SS, Bonventre JV. “Creatinine kinetics and the definition of acute kidney injury.” Journal of the American Society of Nephrology : JASN (2009). PMID: 19244578 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Clinical Presentation, Diagnosis and Workup
  34. [34]

    Ali T, Khan I, Simpson W et al.. “Incidence and outcomes in acute kidney injury: a comprehensive population-based study.” Journal of the American Society of Nephrology : JASN (2007). PMID: 17314324 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature, Renal Replacement Therapy, Dialysis Access & Transplantation
  35. [35]

    Sandokji I, Yamamoto Y, Biswas A et al.. “A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32381598 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature
  36. [36]

    Park S, Cho H, Park S et al.. “Simple Postoperative AKI Risk (SPARK) Classification before Noncardiac Surgery: A Prediction Index Development Study with External Validation.” Journal of the American Society of Nephrology : JASN (2018). PMID: 30563915 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature, Staging and Risk Stratification (KDIGO), Fluid, Electrolyte & Acid-Base Disorders
  37. [37]

    Francoz C, Durand F, Kahn JA et al.. “Hepatorenal Syndrome.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 30996046 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Clinical Presentation, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  38. [38]

    Boyer N, Eldridge J, Prowle JR et al.. “Postoperative Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35710717 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management
  39. [39]

    Goldstein SL, Chawla LS. “Renal angina.” Clinical journal of the American Society of Nephrology : CJASN (2010). PMID: 20299370 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy
  40. [40]

    Patel S, Puri N, Dellinger RP. “Sepsis Management for the Nephrologist.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35551069 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Clinical Presentation, Diagnosis and Workup, Acute Management, Long-term and Definitive Management
  41. [41]

    Cerdá J, Lameire N, Eggers P et al.. “Epidemiology of acute kidney injury.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18216347 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Prevention, Screening & Surveillance
  42. [42]

    Ronco C, Kellum JA, Bellomo R et al.. “Potential interventions in sepsis-related acute kidney injury.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18235149 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  43. [43]

    Griffin BR, Wendt L, Vaughan-Sarrazin M et al.. “Nephrotoxin Exposure and Acute Kidney Injury in Adults.” Clinical journal of the American Society of Nephrology : CJASN (2023). PMID: 36754005 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature, Special Populations & Pregnancy
  44. [44]

    Fan X, Zhuang J, Xiong Z et al.. “Machine learning model predicts acute kidney injury in pediatric patients after cardiac surgery: a systematic review and meta-analysis.” BMC nephrology (2026). PMID: 42121090 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature
  45. [45]

    Afrifa J, Asum K, Fosu SAB et al.. “Prevalence and Causes of Acute Kidney Injury and Chronic Kidney Disease in Ghana: A Systematic Review and Meta-Analysis.” Journal of epidemiology and global health (2026). PMID: 41793628 ↗

    L1SR_OBSCited in: Definition, Classification and Nomenclature
  46. [46]

    Yang L, Xing G, Wang L et al.. “Acute kidney injury in China: a cross-sectional survey.” Lancet (London, England) (2015). PMID: 26466051 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management
  47. [47]

    Lameire NH, Bagga A, Cruz D et al.. “Acute kidney injury: an increasing global concern.” Lancet (London, England) (2013). PMID: 23727171 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Clinical Presentation, Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  48. [48]

    Banerjee D, Ali MA, Wang AY et al.. “Acute kidney injury in acute heart failure-when to worry and when not to worry?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38944413 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Acute Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  49. [49]

    Ricci Z, Ronco C. “Neonatal RIFLE.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2013). PMID: 23625973 ↗

    L5OTHERCited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup
  50. [50]

    Joyce EL, DeAlmeida DR, Fuhrman DY et al.. “eResearch in acute kidney injury: a primer for electronic health record research.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2019). PMID: 29617846 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Diagnosis and Workup, Prevention, Screening & Surveillance
  51. [51]

    Song SM, Jeon J, Jang HR et al.. “Acute kidney injury in bortezomib-treated patients with multiple myeloma.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 36662030 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature, Special Populations & Pregnancy
  52. [52]

    Lane K, Dixon JJ, MacPhee IA et al.. “Renohepatic crosstalk: does acute kidney injury cause liver dysfunction?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2013). PMID: 23685679 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature
  53. [53]

    Sawhney S, Fluck N, Marks A et al.. “Acute kidney injury-how does automated detection perform?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 25925702 ↗

    L2OTHERCited in: Definition, Classification and Nomenclature
  54. [54]

    Warnock DG. “The pressing need for real-time risk assessment of hospital-acquired acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 27461745 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Staging and Risk Stratification (KDIGO)
  55. [55]

    Raina R, Shirode P, Shah R et al.. “Artificial intelligence for predicting paediatric acute kidney injury: a systematic review and meta-analysis.” Clinical kidney journal (2026). PMID: 42079462 ↗

    L2SR_OBSCited in: Definition, Classification and Nomenclature
  56. [56]

    Schefold JC, Filippatos G, Hasenfuss G et al.. “Heart failure and kidney dysfunction: epidemiology, mechanisms and management.” Nature reviews. Nephrology (2016). PMID: 27573728 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Acute Management, Complications (Chronic Systemic Sequelae)
  57. [57]

    Wang Y, Bellomo R. “Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment.” Nature reviews. Nephrology (2017). PMID: 28869251 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Pathophysiology and Mechanism, Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  58. [58]

    Prowle JR, Forni LG, Bell M et al.. “Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.” Nature reviews. Nephrology (2021). PMID: 33976395 ↗

    L1REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Prevention, Screening & Surveillance
  59. [59]

    Prowle JR, Echeverri JE, Ligabo EV et al.. “Fluid balance and acute kidney injury.” Nature reviews. Nephrology (2009). PMID: 20027192 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature
  60. [60]

    Akcan Arikan A, Ostermann M, Goldstein SL et al.. “Sepsis criteria and kidney function: eliminating sex, age and economic status biases.” Nature reviews. Nephrology (2025). PMID: 40506504 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Special Populations & Pregnancy
  61. [61]

    Kellum JA, Ronco C, Bellomo R. “Conceptual advances and evolving terminology in acute kidney disease.” Nature reviews. Nephrology (2021). PMID: 33712812 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Long-term and Definitive Management
  62. [62]

    Desanti De Oliveira B, Xu K, Shen TH et al.. “Molecular nephrology: types of acute tubular injury.” Nature reviews. Nephrology (2019). PMID: 31439924 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature
  63. [63]

    Kellum JA, Prowle JR. “Paradigms of acute kidney injury in the intensive care setting.” Nature reviews. Nephrology (2018). PMID: 29355173 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature
  64. [64]

    Prowle JR, Kirwan CJ, Bellomo R. “Fluid management for the prevention and attenuation of acute kidney injury.” Nature reviews. Nephrology (2013). PMID: 24217464 ↗

    L5REVIEW_NARRATIVECited in: Definition, Classification and Nomenclature, Prevention, Screening & Surveillance
  65. [65]

    Albusta N, Abdulla M, Isa S et al.. “Impact of Pre-Transplant Frailty on Early Outcomes Following Liver Transplantation: A Propensity-Matched Multicenter Cohort Study.” Journal of clinical medicine (2026). PMID: 42278866 ↗

    L2COHORTCited in: Definition, Classification and Nomenclature
  66. [66]

    Gür A, Yazıcı R, Mutlu H et al.. “Diagnostic performance of the lactate dehydrogenase-to-albumin ratio for early acute kidney injury in crush syndrome: a retrospective cohort study.” BMC emergency medicine (2026). PMID: 42177412 ↗

    L2COHORTCited in: Definition, Classification and Nomenclature
  67. [67]

    Xu Z, Li C, Guan C et al.. “Development and external validation of an interpretable early prediction model for acute kidney injury using TabPFN and routine admission data: a retrospective cohort study.” BMC medical informatics and decision making (2026). PMID: 42121180 ↗

    L2COHORTCited in: Definition, Classification and Nomenclature
  68. [68]

    Floege J, Barratt J, Cook HT et al.. “Executive summary of the KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV).” Kidney international (2025). PMID: 40975525 ↗

    L1GUIDELINECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  69. [69]

    Lam CSP, Bozkurt B, Cherney DZI et al.. “Kidney disease and heart failure: recent advances and current challenges: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.” Kidney international (2026). PMID: 41791738 ↗

    L5GUIDELINECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, History and Evolution of Treatment, Prognosis and Natural History
  70. [70]

    Helget LN, Davis-Karim A, O'Dell JR et al.. “Efficacy and Safety of Allopurinol and Febuxostat in Patients With Gout and CKD: Subgroup Analysis of the STOP Gout Trial.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2024). PMID: 38906504 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  71. [71]

    Agarwal R, Green JB, Heerspink HJL et al.. “Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes.” The New England journal of medicine (2025). PMID: 40470996 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  72. [72]

    Mann JFE, Ørsted DD, Brown-Frandsen K et al.. “Liraglutide and Renal Outcomes in Type 2 Diabetes.” The New England journal of medicine (2017). PMID: 28854085 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, History and Evolution of Treatment, Prognosis and Natural History, Prevention, Screening & Surveillance
  73. [73]

    Gaudry S, Hajage D, Schortgen F et al.. “Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.” The New England journal of medicine (2016). PMID: 27181456 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Staging and Risk Stratification (KDIGO), Acute Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  74. [74]

    Fearon WF, Jeremias A, Witberg G et al.. “Angiography-Derived Fractional Flow Reserve to Guide PCI.” The New England journal of medicine (2026). PMID: 41910384 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup
  75. [75]

    Torres VE, Abebe KZ, Chapman AB et al.. “Angiotensin blockade in late autosomal dominant polycystic kidney disease.” The New England journal of medicine (2014). PMID: 25399731 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Fluid, Electrolyte & Acid-Base Disorders, Prognosis and Natural History
  76. [76]

    Hausenloy DJ, Candilio L, Evans R et al.. “Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery.” The New England journal of medicine (2015). PMID: 26436207 ↗

    L1RCTCited in: Pathophysiology and Mechanism
  77. [77]

    Fried LF, Emanuele N, Zhang JH et al.. “Combined angiotensin inhibition for the treatment of diabetic nephropathy.” The New England journal of medicine (2013). PMID: 24206457 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Fluid, Electrolyte & Acid-Base Disorders, Prognosis and Natural History
  78. [78]

    Brar SS, Aharonian V, Mansukhani P et al.. “Haemodynamic-guided fluid administration for the prevention of contrast-induced acute kidney injury: the POSEIDON randomised controlled trial.” Lancet (London, England) (2014). PMID: 24856027 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  79. [79]

    de Moura Pedro RA, Scharanch BC, de Oliveira Araújo L et al.. “Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM).” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2025). PMID: 40774358 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Long-term and Definitive Management, History and Evolution of Treatment, Prognosis and Natural History, Prevention, Screening & Surveillance
  80. [80]

    James MT, Hemmelgarn BR, Wiebe N et al.. “Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study.” Lancet (London, England) (2010). PMID: 21094997 ↗

    L2COHORTCited in: Pathophysiology and Mechanism, Staging and Risk Stratification (KDIGO), Prognosis and Natural History
  81. [81]

    Schunk SJ, Zarbock A, Meersch M et al.. “Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study.” Lancet (London, England) (2019). PMID: 31202596 ↗

    L2COHORTCited in: Pathophysiology and Mechanism, Prognosis and Natural History
  82. [82]

    Wadei HM, Lee DD, Croome KP et al.. “Early Allograft Dysfunction After Liver Transplantation Is Associated With Short- and Long-Term Kidney Function Impairment.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 26663518 ↗

    L2TRIAL_NONRANDOMCited in: Pathophysiology and Mechanism
  83. [83]

    Makkapati S, D'Agati VD, Balsam L. “"Green Smoothie Cleanse" Causing Acute Oxalate Nephropathy.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2017). PMID: 29203127 ↗

    L4CASE_REPORTCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  84. [84]

    Nasr SH, Milliner DS, Wooldridge TD et al.. “Triamterene crystalline nephropathy.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2013). PMID: 23958399 ↗

    L4CASE_REPORTCited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Prognosis and Natural History
  85. [85]

    Siddall E, Khatri M, Radhakrishnan J. “Capillary leak syndrome: etiologies, pathophysiology, and management.” Kidney international (2017). PMID: 28318633 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae)
  86. [86]

    Praga M, González E. “Acute interstitial nephritis.” Kidney international (2010). PMID: 20336051 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  87. [87]

    Liu BC, Tang TT, Lv LL et al.. “Renal tubule injury: a driving force toward chronic kidney disease.” Kidney international (2018). PMID: 29361307 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  88. [88]

    Cortazar FB, Marrone KA, Troxell ML et al.. “Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors.” Kidney international (2016). PMID: 27282937 ↗

    L4OTHERCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  89. [89]

    Xu S, Jia P, Fang Y et al.. “Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation.” Kidney international (2022). PMID: 35227690 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Acute Management, Long-term and Definitive Management, Prevention, Screening & Surveillance
  90. [90]

    Lee LE, Doke T, Mukhi D et al.. “The key role of altered tubule cell lipid metabolism in kidney disease development.” Kidney international (2024). PMID: 38614389 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  91. [91]

    Xu Q, Li ZL, Zhang YL et al.. “Kidney hepcidin protects the collecting duct against ferroptosis in ischemia/reperfusion-induced acute kidney injury.” Kidney international (2025). PMID: 40581167 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Prognosis and Natural History
  92. [92]

    Imberti B, Morigi M, Benigni A. “Potential of mesenchymal stem cells in the repair of tubular injury.” Kidney international supplements (2011). PMID: 25028629 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Prognosis and Natural History
  93. [93]

    Genest DS, Patriquin CJ, Licht C et al.. “Renal Thrombotic Microangiopathy: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2022). PMID: 36509342 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  94. [94]

    Gallo Marin B, Aghagoli G, Hu SL et al.. “Calciphylaxis and Kidney Disease: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2022). PMID: 35970430 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  95. [95]

    Lee SA, Cozzi M, Bush EL et al.. “Distant Organ Dysfunction in Acute Kidney Injury: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2018). PMID: 29866457 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup
  96. [96]

    Inker LA, Titan S. “Measurement and Estimation of GFR for Use in Clinical Practice: Core Curriculum 2021.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34518032 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Prognosis and Natural History
  97. [97]

    Demoulin N, Aydin S, Gillion V et al.. “Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34508834 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  98. [98]

    Becerra LA, Mansour SG. “Exercise and Kidney Health: Core Curriculum 2026.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 41389078 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Fluid, Electrolyte & Acid-Base Disorders, Prevention, Screening & Surveillance
  99. [99]

    Murray SL, Wolf M. “Calcium and Phosphate Disorders: Core Curriculum 2024.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 38099870 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  100. [100]

    Johnson RJ, Bakris GL, Borghi C et al.. “Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2018). PMID: 29496260 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae)
  101. [101]

    Bouquegneau A, Dubois BE, Krzesinski JM et al.. “Anorexia nervosa and the kidney.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2012). PMID: 22609034 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Fluid, Electrolyte & Acid-Base Disorders, Complications (Chronic Systemic Sequelae)
  102. [102]

    Patel JJ, McClave SA. “Nutrition Therapy in Critically Ill Adults.” The New England journal of medicine (2026). PMID: 42418776 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management
  103. [103]

    Rudman-Melnick V, Adam M, Potter A et al.. “Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk.” Journal of the American Society of Nephrology : JASN (2020). PMID: 33115917 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Complications (Chronic Systemic Sequelae)
  104. [104]

    Dixon EE, Wu H, Muto Y et al.. “Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34853151 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Complications (Chronic Systemic Sequelae)
  105. [105]

    Goggins E, Inoue H, Okusa MD. “Neuroimmune Control of Inflammation in Acute Kidney Injury and Multiorgan Dysfunction.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40622772 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Complications (Chronic Systemic Sequelae)
  106. [106]

    Tang TT, Wang B, Li ZL et al.. “Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34127536 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae)
  107. [107]

    Zarjou A, Agarwal A. “Sepsis and acute kidney injury.” Journal of the American Society of Nephrology : JASN (2011). PMID: 21566052 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  108. [108]

    Nath KA, Singh RD, Croatt AJ et al.. “The Aging Kidney and Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2025). PMID: 41563815 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  109. [109]

    Bowe B, Xie Y, Xu E et al.. “Kidney Outcomes in Long COVID.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34470828 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  110. [110]

    Zhang YL, Li XY, Tang TT et al.. “Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40952808 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, History and Evolution of Treatment
  111. [111]

    Xue R, Yiu WH, Chan KW et al.. “Long Non-coding RNA NEAT1 , NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2024). PMID: 39088708 ↗

    L4OTHERCited in: Pathophysiology and Mechanism
  112. [112]

    Shi N, Wang JW, Su G et al.. “N -Acetyl-Tryptophan in Acute Kidney Injury after Cardiac Surgery.” Journal of the American Society of Nephrology : JASN (2025). PMID: 39847454 ↗

    L3OTHERCited in: Pathophysiology and Mechanism
  113. [113]

    Bauerle JD, Grenz A, Kim JH et al.. “Adenosine generation and signaling during acute kidney injury.” Journal of the American Society of Nephrology : JASN (2011). PMID: 21209250 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Complications (Chronic Systemic Sequelae)
  114. [114]

    Hayek SS, Leaf DE, Samman Tahhan A et al.. “Soluble Urokinase Receptor and Acute Kidney Injury.” The New England journal of medicine (2020). PMID: 31995687 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Staging and Risk Stratification (KDIGO), Prevention, Screening & Surveillance
  115. [115]

    Perazella MA, Rosner MH. “Drug-Induced Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35273009 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae)
  116. [116]

    Kuwabara S, Goggins E, Okusa MD. “The Pathophysiology of Sepsis-Associated AKI.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35764395 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae)
  117. [117]

    Nassar TI, Qunibi WY. “AKI Associated with Acute Pancreatitis.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 31118209 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae)
  118. [118]

    Vijayan A, Abdel-Rahman EM, Liu KD et al.. “Recovery after Critical Illness and Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2021). PMID: 34462285 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  119. [119]

    Molitoris BA. “Low-Flow Acute Kidney Injury: The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35584927 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae)
  120. [120]

    Liu KD, Goldstein SL, Vijayan A et al.. “AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI.” Clinical journal of the American Society of Nephrology : CJASN (2020). PMID: 32317329 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management
  121. [121]

    Ledeganck KJ, Gielis EM, Abramowicz D et al.. “MicroRNAs in AKI and Kidney Transplantation.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 30602462 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  122. [122]

    Ross DW, Stevens GR, Wanchoo R et al.. “Left Ventricular Assist Devices and the Kidney.” Clinical journal of the American Society of Nephrology : CJASN (2017). PMID: 29070522 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Staging and Risk Stratification (KDIGO), Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  123. [123]

    McCoy IE, Hsu JY, Zhang X et al.. “Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes.” Clinical journal of the American Society of Nephrology : CJASN (2023). PMID: 37116457 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Prognosis and Natural History
  124. [124]

    Behal ML, Flannery AH, Barreto EF. “Medication Management in the Critically Ill Patient with Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2023). PMID: 36723347 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Long-term and Definitive Management, Prognosis and Natural History
  125. [125]

    Ronco C, Bellomo R, Kellum JA. “Acute kidney injury.” Lancet (London, England) (2019). PMID: 31777389 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Complications (Chronic Systemic Sequelae)
  126. [126]

    Vivarelli M, Gibson K, Sinha A et al.. “Childhood nephrotic syndrome.” Lancet (London, England) (2023). PMID: 37659779 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Long-term and Definitive Management
  127. [127]

    Fakhouri F, Zuber J, Frémeaux-Bacchi V et al.. “Haemolytic uraemic syndrome.” Lancet (London, England) (2017). PMID: 28242109 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae)
  128. [128]

    Noone DG, Iijima K, Parekh R. “Idiopathic nephrotic syndrome in children.” Lancet (London, England) (2018). PMID: 29910038 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  129. [129]

    Zarbock A, Koyner JL, Gomez H et al.. “Sepsis-associated acute kidney injury-treatment standard.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 37401137 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae)
  130. [130]

    Barbir EB, Kitchlu A, Herrmann SM. “Immune checkpoint inhibitor-associated nephritis-treatment standard.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 39138117 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management
  131. [131]

    Dhakal AK, Shrestha D, Preston R et al.. “Acute post-streptococcal glomerulonephritis in children-treatment standard.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40650562 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  132. [132]

    Morelle J, Caravaca-Fontan F, Fakhouri F et al.. “Complement activation in secondary thrombotic microangiopathies.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40372375 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  133. [133]

    Jacobs ME, de Vries DK, Engelse MA et al.. “Endothelial to mesenchymal transition in kidney fibrosis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 37968135 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  134. [134]

    Seibt T, Wahida A, Hoeft K et al.. “The biology of ferroptosis in kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38684468 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Prevention, Screening & Surveillance
  135. [135]

    Kramann R, Kusaba T, Humphreys BD. “Who regenerates the kidney tubule?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 25155054 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  136. [136]

    Ergin B, Kapucu A, Demirci-Tansel C et al.. “The renal microcirculation in sepsis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 24848133 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae)
  137. [137]

    Malyszko J, Kozlowska K, Kozlowski L et al.. “Nephrotoxicity of anticancer treatment.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 28339935 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Prognosis and Natural History
  138. [138]

    Corte-Iglesias V, Saiz ML, Andrade-Lopez AC et al.. “Propionate and butyrate counteract renal damage and progression to chronic kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38794880 ↗

    L4OTHERCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Acute Management, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  139. [139]

    Steenvoorden TS, Rood JAJ, Bemelman FJ et al.. “Alkaline phosphatase treatment of acute kidney injury-an update.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38400561 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Acute Management
  140. [140]

    Zarbock A, Nadim MK, Pickkers P et al.. “Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup.” Nature reviews. Nephrology (2023). PMID: 36823168 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae)
  141. [141]

    Bhargava P, Schnellmann RG. “Mitochondrial energetics in the kidney.” Nature reviews. Nephrology (2017). PMID: 28804120 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  142. [142]

    Messerer DAC, Halbgebauer R, Nilsson B et al.. “Immunopathophysiology of trauma-related acute kidney injury.” Nature reviews. Nephrology (2020). PMID: 32958893 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Complications (Chronic Systemic Sequelae)
  143. [143]

    Tang C, Livingston MJ, Liu Z et al.. “Autophagy in kidney homeostasis and disease.” Nature reviews. Nephrology (2020). PMID: 32704047 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  144. [144]

    Tang C, Cai J, Yin XM et al.. “Mitochondrial quality control in kidney injury and repair.” Nature reviews. Nephrology (2020). PMID: 33235391 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Prevention, Screening & Surveillance
  145. [145]

    Venet F, Monneret G. “Advances in the understanding and treatment of sepsis-induced immunosuppression.” Nature reviews. Nephrology (2017). PMID: 29225343 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  146. [146]

    Murugan R, Bellomo R, Palevsky PM et al.. “Ultrafiltration in critically ill patients treated with kidney replacement therapy.” Nature reviews. Nephrology (2020). PMID: 33177700 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Acute Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae)
  147. [147]

    Chesnaye NC, Carrero JJ, Hecking M et al.. “Differences in the epidemiology, management and outcomes of kidney disease in men and women.” Nature reviews. Nephrology (2023). PMID: 37985869 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  148. [148]

    Bayır H, Dixon SJ, Tyurina YY et al.. “Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney.” Nature reviews. Nephrology (2023). PMID: 36922653 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  149. [149]

    Ferenbach DA, Bonventre JV. “Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.” Nature reviews. Nephrology (2015). PMID: 25643664 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  150. [150]

    Park J, Koutentakis M, Babu A et al.. “Texas statewide incidence and severity of iatrogenic major vascular injury during inpatient laparoscopic surgery: a population-based cohort study.” Surgical endoscopy (2026). PMID: 42384194 ↗

    L2COHORTCited in: Pathophysiology and Mechanism
  151. [151]

    Sadjadi M, Marcello M, Köhler A et al.. “Implementation of the kidney protection strategy in critically ill patients with acute kidney injury - a multi-center prospective cohort study.” Critical care (London, England) (2026). PMID: 42321935 ↗

    L2COHORTCited in: Pathophysiology and Mechanism, Special Populations & Pregnancy
  152. [152]

    Siedlecki A, Irish W, Brennan DC. “Delayed graft function in the kidney transplant.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2011). PMID: 21929642 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  153. [153]

    Williams C, Borges K, Banh T et al.. “Patterns of kidney injury in pediatric nonkidney solid organ transplant recipients.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2018). PMID: 29286569 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Prognosis and Natural History
  154. [154]

    Shi L, Zhou S, Zhao J et al.. “Tubule-derived growth differentiation factor 15 limits renal transplant injury by reprogramming macrophage responses.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2026). PMID: 41581667 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  155. [155]

    Heilman RL, Smith ML, Kurian SM et al.. “Transplanting Kidneys from Deceased Donors With Severe Acute Kidney Injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 25808278 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Staging and Risk Stratification (KDIGO), Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  156. [156]

    Boffa C, van de Leemkolk F, Curnow E et al.. “Transplantation of Kidneys From Donors With Acute Kidney Injury: Friend or Foe?” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2016). PMID: 27428556 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  157. [157]

    Heilman RL, Mathur A, Smith ML et al.. “Increasing the Use of Kidneys From Unconventional and High-Risk Deceased Donors.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2016). PMID: 27172238 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  158. [158]

    Hall IE, Schröppel B, Doshi MD et al.. “Associations of deceased donor kidney injury with kidney discard and function after transplantation.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 25762442 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Diagnosis and Workup
  159. [159]

    Halloran PF, Matas A, Kasiske BL et al.. “Molecular phenotype of kidney transplant indication biopsies with inflammation in scarred areas.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2018). PMID: 30417539 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Diagnosis and Workup
  160. [160]

    Winther S, Svensson M, Jørgensen HS et al.. “Repeated Contrast Administration Is Associated With Low Risk of Postcontrast Acute Kidney Injury and Long-Term Complications in Patients With Severe Chronic Kidney Disease.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 26663699 ↗

    L2OTHERCited in: Pathophysiology and Mechanism, Clinical Presentation, Staging and Risk Stratification (KDIGO), Prevention, Screening & Surveillance
  161. [161]

    Steenvoorden TS, Evers L, Vogt L et al.. “The differential impact of early graft dysfunction in kidney donation after brain death and after circulatory death: Insights from the Dutch National Transplant Registry.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2024). PMID: 39343037 ↗

    L2OTHERCited in: Pathophysiology and Mechanism
  162. [162]

    M KK, V H N, P Y et al.. “Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial.” Acta anaesthesiologica Scandinavica (2026). PMID: 42298739 ↗

    L5TRIAL_NONRANDOMCited in: Pathophysiology and Mechanism, Acute Management, Complications (Chronic Systemic Sequelae), Prevention, Screening & Surveillance
  163. [163]

    Karakoc AZ, Ozcan E, Akardere OF et al.. “The Effect of Preoperative Hydration on Cardiac Surgery-Associated Acute Kidney Injury.” Brazilian journal of cardiovascular surgery (2026). PMID: 42398042 ↗

    L1RCTCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Long-term and Definitive Management, Prognosis and Natural History, Prevention, Screening & Surveillance
  164. [164]

    Liu W, Chen Q, Huang T et al.. “The first 24-h negative fluid balance is related to lower short-term mortality but higher AKI progression in critically ill heart failure: a retrospective cohort study.” Therapeutic advances in cardiovascular disease (2026). PMID: 42304606 ↗

    L2COHORTCited in: Pathophysiology and Mechanism, Diagnosis and Workup, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  165. [165]

    Morikawa T, Dotsu Y, Torigoe K et al.. “Cisplatin re-challenge following recovery from carboplatin-induced, biopsy-proven acute tubular necrosis in a 57-year-old patient with squamous-transformed non-small cell lung cancer: a case report.” Translational lung cancer research (2026). PMID: 42433252 ↗

    L4CASE_REPORTCited in: Pathophysiology and Mechanism
  166. [166]

    Morrissey B. “Acute urinary retention presenting as inferior pseudo-STEMI: A case report.” The American journal of emergency medicine (2026). PMID: 42330710 ↗

    L4CASE_REPORTCited in: Pathophysiology and Mechanism, Fluid, Electrolyte & Acid-Base Disorders
  167. [167]

    Jiang Y, Xu J, Wang Z et al.. “From intracellular processing to renal phenotypes: a mechanism-informed framework for interpreting kidney injury and electrolyte patterns with antibody-drug conjugates in solid tumors.” Frontiers in pharmacology (2026). PMID: 42434135 ↗

    L5REVIEW_NARRATIVECited in: Pathophysiology and Mechanism
  168. [168]

    Ma J, Yiu WH, Lok SWY et al.. “C5a/C5aR1 mediates AKI-CKD transition by enhancing autophagy.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 42429470 ↗

    L5OTHERCited in: Pathophysiology and Mechanism
  169. [169]

    Kim H, Migneault F, Lan S et al.. “Microvascular autophagy and caspase-3 activation are central regulators of renal fibrosis after ischemia-reperfusion.” JCI insight (2026). PMID: 42417162 ↗

    L5OTHERCited in: Pathophysiology and Mechanism
  170. [170]

    Lian R, Rao S, Zheng Z et al.. “Finerenone attenuates chronic fibrotic remodeling during the AKI-CKD transition in an ischemia-reperfusion-induced acute kidney injury mouse model.” Renal failure (2026). PMID: 42414246 ↗

    L5OTHERCited in: Pathophysiology and Mechanism, Long-term and Definitive Management
  171. [171]

    Coca SG, Singanamala S, Parikh CR. “Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis.” Kidney international (2011). PMID: 22113526 ↗

    L2SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  172. [172]

    See EJ, Jayasinghe K, Glassford N et al.. “Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure.” Kidney international (2018). PMID: 30473140 ↗

    L2SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  173. [173]

    Siew ED, Hellwege JN, Hung AM et al.. “Genome-wide association study of hospitalized patients and acute kidney injury.” Kidney international (2024). PMID: 38797326 ↗

    L3SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy
  174. [174]

    Chung EYM, Palmer SC, Natale P et al.. “Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34364906 ↗

    L2SR_OBSCited in: Epidemiology, Etiology and Risk Factors
  175. [175]

    Van den Eynde J, Cloet N, Van Lerberghe R et al.. “Strategies to Prevent Acute Kidney Injury after Pediatric Cardiac Surgery: A Network Meta-Analysis.” Clinical journal of the American Society of Nephrology : CJASN (2021). PMID: 34620647 ↗

    L1SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy, Prevention, Screening & Surveillance
  176. [176]

    Wright JT, Williamson JD, Whelton PK et al.. “A Randomized Trial of Intensive versus Standard Blood-Pressure Control.” The New England journal of medicine (2015). PMID: 26551272 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  177. [177]

    Lincoff AM, Bhasin S, Flevaris P et al.. “Cardiovascular Safety of Testosterone-Replacement Therapy.” The New England journal of medicine (2023). PMID: 37326322 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  178. [178]

    Bagshaw SM, Wald R, Adhikari NKJ et al.. “Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.” The New England journal of medicine (2020). PMID: 32668114 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Special Populations & Pregnancy
  179. [179]

    Finfer S, Micallef S, Hammond N et al.. “Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults.” The New England journal of medicine (2022). PMID: 35041780 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  180. [180]

    Bhatt DL, Szarek M, Steg PG et al.. “Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure.” The New England journal of medicine (2020). PMID: 33200892 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  181. [181]

    Landoni G, Monaco F, Ti LK et al.. “A Randomized Trial of Intravenous Amino Acids for Kidney Protection.” The New England journal of medicine (2024). PMID: 38865168 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  182. [182]

    Lewis CE, Fine LJ, Beddhu S et al.. “Final Report of a Trial of Intensive versus Standard Blood-Pressure Control.” The New England journal of medicine (2021). PMID: 34010531 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  183. [183]

    Lee TC, Barina LA, Walls G et al.. “Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia.” The New England journal of medicine (2026). PMID: 42308484 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Special Populations & Pregnancy
  184. [184]

    Reardon MJ, Van Mieghem NM, Popma JJ et al.. “Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients.” The New England journal of medicine (2017). PMID: 28304219 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae)
  185. [185]

    Monaco F, Lei C, Bonizzoni MA et al.. “A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery.” The New England journal of medicine (2025). PMID: 40503713 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Prevention, Screening & Surveillance
  186. [186]

    Veltkamp DMJ, Porras CP, Gant CM et al.. “Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40424522 ↗

    L1SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  187. [187]

    Wilson T, Quan S, Cheema K et al.. “Risk prediction models for acute kidney injury following major noncardiac surgery: systematic review.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 26705194 ↗

    L2SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  188. [188]

    Gaudry S, Hajage D, Martin-Lefevre L et al.. “Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial.” Lancet (London, England) (2021). PMID: 33812488 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Acute Management, Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Special Populations & Pregnancy
  189. [189]

    Liu J, Li Y, Ge J et al.. “Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial.” Lancet (London, England) (2024). PMID: 38945140 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  190. [190]

    Heyland DK, Patel J, Compher C et al.. “The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial.” Lancet (London, England) (2023). PMID: 36708732 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment
  191. [191]

    Huang C, Huang L, Wang Y et al.. “6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.” Lancet (London, England) (2021). PMID: 33428867 ↗

    L2COHORTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  192. [192]

    Zarbock A, Ostermann M, Forni L et al.. “A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.” Lancet (London, England) (2025). PMID: 41242333 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  193. [193]

    Jaber S, Paugam C, Futier E et al.. “Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial.” Lancet (London, England) (2018). PMID: 29910040 ↗

    L1TRIAL_NONRANDOMCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  194. [194]

    Makkar RR, Thourani VH, Vahl TP et al.. “Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study.” Lancet (London, England) (2025). PMID: 41260228 ↗

    L4TRIAL_NONRANDOMCited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae)
  195. [195]

    Chaudhry ZS, Williams JD, Vahia A et al.. “Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients: A cohort study.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32654332 ↗

    L2COHORTCited in: Epidemiology, Etiology and Risk Factors
  196. [196]

    Forker CM, Miano TA, Reilly JP et al.. “Postreperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2019). PMID: 31017370 ↗

    L2TRIAL_NONRANDOMCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  197. [197]

    Chen C, Wei X, Han Y et al.. “Efficacy and safety of haemostatic agents for patients receiving antiplatelet therapy before coronary artery bypass grafting: a protocol for a systematic review and network meta-analysis of randomised controlled trials.” BMJ open (2026). PMID: 42425562 ↗

    L5SR_MA_RCTCited in: Epidemiology, Etiology and Risk Factors
  198. [198]

    Herrmann SM, Abudayyeh A, Gupta S et al.. “Diagnosis and management of immune checkpoint inhibitor-associated nephrotoxicity: a position statement from the American Society of Onco-nephrology.” Kidney international (2024). PMID: 39455026 ↗

    L1OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  199. [199]

    Matsuura R, Doi K, Rabb H. “Acute kidney injury and distant organ dysfunction-network system analysis.” Kidney international (2023). PMID: 37030663 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management
  200. [200]

    Barrera-Chimal J, Girerd S, Jaisser F. “Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis.” Kidney international (2019). PMID: 31133455 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  201. [201]

    Natu AA, Gupta I, Leung N et al.. “Clonal monocytosis of renal significance.” Kidney international (2024). PMID: 39299498 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  202. [202]

    Khraisat O, Khan F, Asif A et al.. “Preventive efficacy of oxygen therapy against contrast-associated acute kidney injury in patients undergoing coronary angiography: a systematic review and meta-analysis of randomized controlled trials.” BMC nephrology (2026). PMID: 42387412 ↗

    L1SR_MA_RCTCited in: Epidemiology, Etiology and Risk Factors
  203. [203]

    Luyckx VA, Tuttle KR, Garcia-Garcia G et al.. “Reducing major risk factors for chronic kidney disease.” Kidney international supplements (2017). PMID: 30675422 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  204. [204]

    Calice-Silva V, Neyra JA, Ferreiro Fuentes A et al.. “Capacity for the management of kidney failure in the International Society of Nephrology Latin America region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).” Kidney international supplements (2024). PMID: 38618500 ↗

    L4REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Prevention, Screening & Surveillance
  205. [205]

    Prikhodina L, Komissarov K, Bulanov N et al.. “Capacity for the management of kidney failure in the International Society of Nephrology Newly Independent States and Russia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).” Kidney international supplements (2024). PMID: 38618496 ↗

    L4REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  206. [206]

    Lowe-Jones R, Ethier I, Fisher LA et al.. “Capacity for the management of kidney failure in the International Society of Nephrology North America and the Caribbean region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).” Kidney international supplements (2024). PMID: 38618503 ↗

    L4REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  207. [207]

    See EJ, Alrukhaimi M, Ashuntantang GE et al.. “Global coverage of health information systems for kidney disease: availability, challenges, and opportunities for development.” Kidney international supplements (2018). PMID: 30675441 ↗

    L4REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Prevention, Screening & Surveillance
  208. [208]

    Pippias M, Alfano G, Kelly DM et al.. “Capacity for the management of kidney failure in the International Society of Nephrology Western Europe region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).” Kidney international supplements (2024). PMID: 38618502 ↗

    L4REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Prevention, Screening & Surveillance
  209. [209]

    MacLaughlin HL, Friedman AN, Ikizler TA. “Nutrition in Kidney Disease: Core Curriculum 2022.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34862042 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  210. [210]

    Griffin BR, Liu KD, Teixeira JP. “Critical Care Nephrology: Core Curriculum 2020.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 31982214 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  211. [211]

    Xiong C, Jia Y, Wu X et al.. “Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2022). PMID: 36586561 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  212. [212]

    McCoy IE, Chertow GM. “AKI-A Relevant Safety End Point?” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 32037098 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Diagnosis and Workup
  213. [213]

    Coca SG. “Acute kidney injury in elderly persons.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2010). PMID: 20346560 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Special Populations & Pregnancy
  214. [214]

    Yang Y, Shan X, Tang X et al.. “Incidence and risk factors of acute kidney injury following Stanford type A aortic dissection surgery: a systematic review and meta-analysis.” Frontiers in cardiovascular medicine (2026). PMID: 42375845 ↗

    L2SR_OBSCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), History and Evolution of Treatment
  215. [215]

    French J, Bomphrey L, Manta A et al.. “Hyperosmolar hyperglycaemic state: a systematic review and meta-analysis.” BMJ open diabetes research & care (2026). PMID: 42373194 ↗

    L4SR_OBSCited in: Epidemiology, Etiology and Risk Factors
  216. [216]

    Cortazar FB, Kibbelaar ZA, Glezerman IG et al.. “Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study.” Journal of the American Society of Nephrology : JASN (2020). PMID: 31896554 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Acute Management, Special Populations & Pregnancy
  217. [217]

    Nie S, Li Y, Sun Y et al.. “Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-Cause Mortality: Target Trial Emulation Studies.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40531580 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors
  218. [218]

    Babroudi S, Weiner DE, Neyra JA et al.. “Acute Kidney Injury Receiving Dialysis and Dialysis Care after Hospital Discharge.” Journal of the American Society of Nephrology : JASN (2024). PMID: 38652567 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  219. [219]

    Rifkin DE, Coca SG, Kalantar-Zadeh K. “Does AKI truly lead to CKD?” Journal of the American Society of Nephrology : JASN (2012). PMID: 22460531 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  220. [220]

    Perazella MA, Shirali AC. “Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future.” Journal of the American Society of Nephrology : JASN (2018). PMID: 29959196 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  221. [221]

    James MT, Wald R, Bell CM et al.. “Weekend hospital admission, acute kidney injury, and mortality.” Journal of the American Society of Nephrology : JASN (2010). PMID: 20395373 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  222. [222]

    Lafrance JP, Miller DR. “Acute kidney injury associates with increased long-term mortality.” Journal of the American Society of Nephrology : JASN (2009). PMID: 20019168 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  223. [223]

    Ishani A, Xue JL, Himmelfarb J et al.. “Acute kidney injury increases risk of ESRD among elderly.” Journal of the American Society of Nephrology : JASN (2008). PMID: 19020007 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, History and Evolution of Treatment
  224. [224]

    Siew ED, Peterson JF, Eden SK et al.. “Outpatient nephrology referral rates after acute kidney injury.” Journal of the American Society of Nephrology : JASN (2011). PMID: 22158435 ↗

    L3OTHERCited in: Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  225. [225]

    Churpek MM, Fatima A, Anjorin O et al.. “Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial.” JAMA network open (2026). PMID: 42430171 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Long-term and Definitive Management, History and Evolution of Treatment, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  226. [226]

    Wang X, Liu Y, Wang Z et al.. “Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial.” Open heart (2026). PMID: 42425722 ↗

    L1RCTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment
  227. [227]

    Schneider AG, Vandenberghe W, Bellomo R et al.. “Acute kidney injury-epidemiology in intensive care unit patients 2: study protocol for a prospective international multicentre cohort study.” BMJ open (2026). PMID: 42425561 ↗

    L5COHORTCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  228. [228]

    Ding R, Yang Y, Xiang S et al.. “Compartment syndrome is associated with acute kidney injury following revascularisation in patients with lower extremity arterial occlusive disease: a retrospective cohort study.” Renal failure (2026). PMID: 42425544 ↗

    L3COHORTCited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  229. [229]

    Wang Y, Wang X, Wang X et al.. “Impact of acute kidney injury in different ECMO modalities: a multicenter retrospective study on risk factors and mortality.” Renal failure (2026). PMID: 42414252 ↗

    L3COHORTCited in: Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), History and Evolution of Treatment
  230. [230]

    Teles RM, Menezes RC, Ferreira IBB et al.. “ICU-acquired acute kidney injury in critically ill adults: a retrospective cohort study of risk factors and KDIGO stage dynamics in a Brazilian ICU.” Renal failure (2026). PMID: 42410341 ↗

    L3COHORTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy
  231. [231]

    Youmbi CT, Santos A, Bridger A et al.. “Acute Kidney Injury Following Antibiotic-Loaded Spacer Insertion in Two-Stage Knee Arthroplasty Revision for Periprosthetic Joint Infection: A Retrospective Cohort Study.” The Journal of arthroplasty (2026). PMID: 42409293 ↗

    L3COHORTCited in: Epidemiology, Etiology and Risk Factors, Staging and Risk Stratification (KDIGO)
  232. [232]

    Pan K, Hou X, Li J et al.. “Risk of acute kidney injury in patients on concomitant vancomycin and piperacillin-tazobactam compared to vancomycin and other beta-lactam agents: a large multicenter retrospective cohort study from China.” Microbiology spectrum (2026). PMID: 42405788 ↗

    L3COHORTCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation
  233. [233]

    Brocklebank V, Wood KM, Kavanagh D. “Thrombotic Microangiopathy and the Kidney.” Clinical journal of the American Society of Nephrology : CJASN (2017). PMID: 29042465 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  234. [234]

    Yang B, Xie Y, Guo M et al.. “Nephrotoxicity and Chinese Herbal Medicine.” Clinical journal of the American Society of Nephrology : CJASN (2018). PMID: 29615394 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  235. [235]

    Lea-Henry TN, Carland JE, Stocker SL et al.. “Clinical Pharmacokinetics in Kidney Disease: Fundamental Principles.” Clinical journal of the American Society of Nephrology : CJASN (2018). PMID: 29934432 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  236. [236]

    Gupta S, Gudsoorkar P, Jhaveri KD. “Acute Kidney Injury in Critically Ill Patients with Cancer.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35338071 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  237. [237]

    Cullaro G, Kanduri SR, Velez JCQ. “Acute Kidney Injury in Patients with Liver Disease.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35902128 ↗

    L5OTHERCited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  238. [238]

    Ostermann M, Lumlertgul N, Jeong R et al.. “Acute kidney injury.” Lancet (London, England) (2025). PMID: 39826969 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prevention, Screening & Surveillance
  239. [239]

    Jha V, Garcia-Garcia G, Iseki K et al.. “Chronic kidney disease: global dimension and perspectives.” Lancet (London, England) (2013). PMID: 23727169 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae)
  240. [240]

    Mehta S, Lightle A, Judson MA. “Renal sarcoidosis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 35867874 ↗

    L5OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  241. [241]

    Zoccali C, Lameire N, Ronco C et al.. “Acute kidney injury, acute kidney disease and chronic kidney disease: challenges and research perspectives.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40353771 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  242. [242]

    Kellum JA, van Till JWO, Mulligan G. “Targeting acute kidney injury in COVID-19.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2020). PMID: 33022712 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Prognosis and Natural History
  243. [243]

    Moreno JA, Martín-Cleary C, Gutiérrez E et al.. “Haematuria: the forgotten CKD factor?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2012). PMID: 22287699 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  244. [244]

    Milburn J, Jones R, Levy JB. “Renal effects of novel antiretroviral drugs.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 27190354 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Diagnosis and Workup, Long-term and Definitive Management
  245. [245]

    Desir GV, Peixoto AJ. “Renalase in hypertension and kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2013). PMID: 24137013 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  246. [246]

    Hoste EAJ, Kellum JA, Selby NM et al.. “Global epidemiology and outcomes of acute kidney injury.” Nature reviews. Nephrology (2018). PMID: 30135570 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Prevention, Screening & Surveillance
  247. [247]

    Legrand M, Clark AT, Neyra JA et al.. “Acute kidney injury in patients with burns.” Nature reviews. Nephrology (2023). PMID: 37758939 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  248. [248]

    Vijayan A. “Tackling AKI: prevention, timing of dialysis and follow-up.” Nature reviews. Nephrology (2021). PMID: 33335277 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  249. [249]

    Cerda J, Kashani K, Ostermann M et al.. “The global epidemiology of acute kidney injury: challenges and opportunities.” Nature reviews. Nephrology (2025). PMID: 41350436 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management
  250. [250]

    Nelson-Piercy C, Srisawat N, Kashani K et al.. “Pregnancy-associated acute kidney injury - consensus report of the 32nd Acute Disease Quality Initiative workgroup.” Nature reviews. Nephrology (2025). PMID: 40681846 ↗

    L1OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Acute Management, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  251. [251]

    James MT, Bhatt M, Pannu N et al.. “Long-term outcomes of acute kidney injury and strategies for improved care.” Nature reviews. Nephrology (2020). PMID: 32051567 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Long-term and Definitive Management, Prognosis and Natural History
  252. [252]

    Daher EF, da Silva Junior GB, Trivedi M et al.. “Kidney complications of parasitic diseases.” Nature reviews. Nephrology (2022). PMID: 35347315 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors, Long-term and Definitive Management
  253. [253]

    Ivković V, Anandh U, Bell S et al.. “Long COVID and the kidney.” Nature reviews. Nephrology (2025). PMID: 40908304 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  254. [254]

    Nair V, Jandovitz N, Hirsch JS et al.. “COVID-19 in kidney transplant recipients.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32351040 ↗

    L4OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  255. [255]

    Clajus C, Hanke N, Gottlieb J et al.. “Renal comorbidity after solid organ and stem cell transplantation.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2012). PMID: 22676355 ↗

    L5REVIEW_NARRATIVECited in: Epidemiology, Etiology and Risk Factors
  256. [256]

    Caillard S, Chavarot N, Francois H et al.. “Is COVID-19 infection more severe in kidney transplant recipients?” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 33259686 ↗

    L2OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  257. [257]

    Xia VW, Worapot A, Huang S et al.. “Postoperative atrial fibrillation in liver transplantation.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 25657037 ↗

    L2OTHERCited in: Epidemiology, Etiology and Risk Factors, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae)
  258. [258]

    Cravedi P, Mothi SS, Azzi Y et al.. “COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32649791 ↗

    L4OTHERCited in: Epidemiology, Etiology and Risk Factors, Clinical Presentation, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  259. [259]

    Puttappa A, Gaurav R, Kakhandki V et al.. “Normothermic regional and ex situ perfusion reduces postreperfusion syndrome in donation after circulatory death liver transplantation: A retrospective comparative study.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2025). PMID: 39826893 ↗

    L2OTHERCited in: Epidemiology, Etiology and Risk Factors, Complications (Chronic Systemic Sequelae), Prevention, Screening & Surveillance
  260. [260]

    Ostermann M, Bellomo R, Burdmann EA et al.. “Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.” Kidney international (2020). PMID: 32709292 ↗

    L5GUIDELINECited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, History and Evolution of Treatment
  261. [261]

    Abdelhafez M, Nayfeh T, Atieh A et al.. “Diagnostic Performance of Fractional Excretion of Sodium for the Differential Diagnosis of Acute Kidney Injury: A Systematic Review and Meta-Analysis.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35545442 ↗

    L1SR_OBSCited in: Clinical Presentation, Diagnosis and Workup, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae)
  262. [262]

    Leon MB, Smith CR, Mack MJ et al.. “Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients.” The New England journal of medicine (2016). PMID: 27040324 ↗

    L1RCTCited in: Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  263. [263]

    Olsen HT, Nedergaard HK, Strøm T et al.. “Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.” The New England journal of medicine (2020). PMID: 32068366 ↗

    L1RCTCited in: Clinical Presentation, Complications (Chronic Systemic Sequelae)
  264. [264]

    Kapadia SR, Makkar R, Leon M et al.. “Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement.” The New England journal of medicine (2022). PMID: 36121045 ↗

    L1RCTCited in: Clinical Presentation
  265. [265]

    Lemkes JS, Janssens GN, van der Hoeven NW et al.. “Coronary Angiography after Cardiac Arrest without ST-Segment Elevation.” The New England journal of medicine (2019). PMID: 30883057 ↗

    L1RCTCited in: Clinical Presentation, Diagnosis and Workup, Prognosis and Natural History
  266. [266]

    Chawla LS, Bellomo R, Bihorac A et al.. “Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.” Nature reviews. Nephrology (2017). PMID: 28239173 ↗

    L5GUIDELINECited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, History and Evolution of Treatment
  267. [267]

    Verstovsek S, Gerds AT, Vannucchi AM et al.. “Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study.” Lancet (London, England) (2023). PMID: 36709073 ↗

    L1RCTCited in: Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, History and Evolution of Treatment, Complications (Chronic Systemic Sequelae)
  268. [268]

    Huang C, Huang L, Wang Y et al.. “6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.” Lancet (London, England) (2023). PMID: 37321233 ↗

    L2COHORTCited in: Clinical Presentation, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  269. [269]

    Moore PK, Hsu RK, Liu KD. “Management of Acute Kidney Injury: Core Curriculum 2018.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2018). PMID: 29478864 ↗

    L5CASE_REPORTCited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  270. [270]

    Bnaya A, Abu-Amer N, Beckerman P et al.. “Acute Kidney Injury and Hair-Straightening Products: A Case Series.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 36610611 ↗

    L4CASE_REPORTCited in: Clinical Presentation
  271. [271]

    Nasr SH, Kudose S, Valeri AM et al.. “Clinicopathologic Characteristics of Crystalglobulin-Induced Nephropathy: A Case Series.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2024). PMID: 38908425 ↗

    L4CASE_REPORTCited in: Clinical Presentation, Special Populations & Pregnancy
  272. [272]

    Rosner MH, Husain-Syed F, Reis T et al.. “Uremic encephalopathy.” Kidney international (2021). PMID: 34736971 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  273. [273]

    Sharma P, Uppal NN, Wanchoo R et al.. “COVID-19-Associated Kidney Injury: A Case Series of Kidney Biopsy Findings.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32660970 ↗

    L4CASE_REPORTCited in: Clinical Presentation, Diagnosis and Workup, Special Populations & Pregnancy
  274. [274]

    Baker M, Perazella MA. “NSAIDs in CKD: Are They Safe?” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 32479922 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Complications (Chronic Systemic Sequelae)
  275. [275]

    Cavanaugh C, Perazella MA. “Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2018). PMID: 30249419 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Acute Management
  276. [276]

    João RB, Soares LR, Ragazzo PC et al.. “CDK4/6 inhibitor-statin interaction and rhabdomyolysis in breast cancer treatment: a case-based systematic review.” Cancer chemotherapy and pharmacology (2026). PMID: 42380684 ↗

    L4SR_OBSCited in: Clinical Presentation, Long-term and Definitive Management, Special Populations & Pregnancy
  277. [277]

    Siew ED, Ware LB, Ikizler TA. “Biological markers of acute kidney injury.” Journal of the American Society of Nephrology : JASN (2011). PMID: 21493774 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup
  278. [278]

    Hull TD, Agarwal A, Hoyt K. “New Ultrasound Techniques Promise Further Advances in AKI and CKD.” Journal of the American Society of Nephrology : JASN (2017). PMID: 28923914 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management, Prognosis and Natural History
  279. [279]

    Munshi R, Johnson A, Siew ED et al.. “MCP-1 gene activation marks acute kidney injury.” Journal of the American Society of Nephrology : JASN (2010). PMID: 21071523 ↗

    L3OTHERCited in: Clinical Presentation, Diagnosis and Workup, Special Populations & Pregnancy
  280. [280]

    Famulski KS, de Freitas DG, Kreepala C et al.. “Molecular phenotypes of acute kidney injury in kidney transplants.” Journal of the American Society of Nephrology : JASN (2012). PMID: 22343120 ↗

    L3OTHERCited in: Clinical Presentation, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation
  281. [281]

    Ran X, Wang Z, Shao J et al.. “Machine learning-assisted prognostic model for mortality in ICU patients with culture-confirmed Klebsiella pneumoniae infection: a preliminary single-center retrospective cohort study.” Frontiers in cellular and infection microbiology (2026). PMID: 42404781 ↗

    L2COHORTCited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy
  282. [282]

    Hu J, Shu B, Zhang D et al.. “Development and validation of an explainable machine learning model for predicting acute kidney injury in critically ill patients with primary peritonitis: a multicenter cohort study.” Renal failure (2026). PMID: 42349900 ↗

    L2COHORTCited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  283. [283]

    Kashani K, Omer T, Shaw AD. “The Intensivist's Perspective of Shock, Volume Management, and Hemodynamic Monitoring.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35379765 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Acute Management, History and Evolution of Treatment
  284. [284]

    Bellomo R, Kellum JA, Ronco C. “Acute kidney injury.” Lancet (London, England) (2012). PMID: 22617274 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  285. [285]

    Michael M, Bagga A, Sartain SE et al.. “Haemolytic uraemic syndrome.” Lancet (London, England) (2022). PMID: 36272423 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae)
  286. [286]

    Charlton JR, Portilla D, Okusa MD. “A basic science view of acute kidney injury biomarkers.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 24385545 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup
  287. [287]

    Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J et al.. “MicroRNAs in kidney transplantation.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 25170095 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  288. [288]

    Joseph A, Harel S, Mesnard L et al.. “Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38658194 ↗

    L4OTHERCited in: Clinical Presentation, Staging and Risk Stratification (KDIGO)
  289. [289]

    Legrand M, Bell S, Forni L et al.. “Pathophysiology of COVID-19-associated acute kidney injury.” Nature reviews. Nephrology (2021). PMID: 34226718 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Staging and Risk Stratification (KDIGO)
  290. [290]

    Hennessy A, Ng J, Makris A. “The pathophysiology of pre-eclampsia.” Nature reviews. Nephrology (2026). PMID: 42174049 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation
  291. [291]

    Fähling M, Seeliger E, Patzak A et al.. “Understanding and preventing contrast-induced acute kidney injury.” Nature reviews. Nephrology (2017). PMID: 28138128 ↗

    L5REVIEW_NARRATIVECited in: Clinical Presentation, Diagnosis and Workup, Prevention, Screening & Surveillance
  292. [292]

    Famulski KS, Reeve J, de Freitas DG et al.. “Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2013). PMID: 23356967 ↗

    L3OTHERCited in: Clinical Presentation, Diagnosis and Workup, Long-term and Definitive Management
  293. [293]

    Demirhan S, Munoz FM, Valencia Deray KG et al.. “Body surface area compared to body weight dosing of valganciclovir is associated with increased toxicity in pediatric solid organ transplantation recipients.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2023). PMID: 37499799 ↗

    L2OTHERCited in: Clinical Presentation, Long-term and Definitive Management
  294. [294]

    Zeiner S, Kothari RP, Reddy M et al.. “High body mass index at liver transplantation: A retrospective single-center analysis of blood product utilization and postoperative outcomes.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2025). PMID: 40882844 ↗

    L2OTHERCited in: Clinical Presentation
  295. [295]

    Nadim MK, Davis CL, Sung R et al.. “Simultaneous liver-kidney transplantation: a survey of US transplant centers.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2012). PMID: 22759208 ↗

    L5OTHERCited in: Clinical Presentation, Staging and Risk Stratification (KDIGO)
  296. [296]

    Einecke G, Reeve J, Gupta G et al.. “Factors associated with kidney graft survival in pure antibody-mediated rejection at the time of indication biopsy: Importance of parenchymal injury but not disease activity.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32594646 ↗

    L2OTHERCited in: Clinical Presentation
  297. [297]

    Cheng L, Pan C, Wang K et al.. “Primary aldosteronism-induced hypokalemic rhabdomyolysis syndrome: a case report and literature review.” Frontiers in medicine (2026). PMID: 42415812 ↗

    L4CASE_REPORTCited in: Clinical Presentation
  298. [298]

    Banerjee P, Sahu P, Naaz Z et al.. “Posterior Reversible Encephalopathy Syndrome in Eclampsia: A Prospective Study of Risk Factors and Outcomes.” Cureus (2026). PMID: 42403838 ↗

    L2COHORTCited in: Clinical Presentation
  299. [299]

    Ge T, Qiu J, Wang Z et al.. “Cytomegalovirus enteritis in a patient with AKI after type B aortic dissection surgery: a case report.” BMC infectious diseases (2026). PMID: 42401812 ↗

    L4CASE_REPORTCited in: Clinical Presentation, Prevention, Screening & Surveillance
  300. [300]

    Weisbord SD, Gallagher M, Jneid H et al.. “Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine.” The New England journal of medicine (2017). PMID: 29130810 ↗

    L1RCTCited in: Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  301. [301]

    Myburgh JA, Finfer S, Bellomo R et al.. “Hydroxyethyl starch or saline for fluid resuscitation in intensive care.” The New England journal of medicine (2012). PMID: 23075127 ↗

    L1RCTCited in: Diagnosis and Workup, Prognosis and Natural History
  302. [302]

    Wilson FP, Shashaty M, Testani J et al.. “Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial.” Lancet (London, England) (2015). PMID: 25726515 ↗

    L1RCTCited in: Diagnosis and Workup, History and Evolution of Treatment
  303. [303]

    Greenberg B, Taylor M, Adler E et al.. “Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease.” The New England journal of medicine (2024). PMID: 39556016 ↗

    L4TRIAL_NONRANDOMCited in: Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  304. [304]

    Bridoux F, Leung N, Belmouaz M et al.. “Management of acute kidney injury in symptomatic multiple myeloma.” Kidney international (2021). PMID: 33440212 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  305. [305]

    Huang J, Cui S, Chi X et al.. “Dynamically visualizing profibrotic maladaptive repair after acute kidney injury by fibroblast activation protein imaging.” Kidney international (2024). PMID: 39098582 ↗

    L5OTHERCited in: Diagnosis and Workup, Long-term and Definitive Management, History and Evolution of Treatment, Prognosis and Natural History
  306. [306]

    Becker GJ, Garigali G, Fogazzi GB. “Advances in Urine Microscopy.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2016). PMID: 26806004 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  307. [307]

    Carrero JJ, Fu EL, Sang Y et al.. “Discordances Between Creatinine- and Cystatin C-Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practice.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 37354936 ↗

    L2OTHERCited in: Diagnosis and Workup
  308. [308]

    Xie CM, Shen MQ, Yao YT et al.. “Hypotension prediction index in surgical patients: A systematic review and meta-analysis of randomized controlled trials.” Medicine (2026). PMID: 42299539 ↗

    L1SR_MA_RCTCited in: Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  309. [309]

    Böhner AMC, Jacob AM, Heuser C et al.. “Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34599036 ↗

    L5OTHERCited in: Diagnosis and Workup
  310. [310]

    Lunyera J, Clare RM, Chiswell K et al.. “Racial Differences in AKI Incidence Following Percutaneous Coronary Intervention.” Journal of the American Society of Nephrology : JASN (2020). PMID: 33443096 ↗

    L2OTHERCited in: Diagnosis and Workup
  311. [311]

    Kaddourah A, Basu RK, Bagshaw SM et al.. “Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults.” The New England journal of medicine (2016). PMID: 27959707 ↗

    L2OTHERCited in: Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae)
  312. [312]

    Lipinski A, Paulmann M, Müller S et al.. “"Drug Reaction with Eosinophilia and Systemic Symptoms" (DRESS): Long-term Outcomes Based on Severity - A Cohort Study.” Acta dermato-venereologica (2026). PMID: 42328995 ↗

    L2COHORTCited in: Diagnosis and Workup, Complications (Chronic Systemic Sequelae), Special Populations & Pregnancy
  313. [313]

    Klopp A, de Rosa S, Schmidt EA et al.. “Admission creatinine and outcomes in very elderly critically ill patients: a retrospective cohort study.” BMC geriatrics (2026). PMID: 42271276 ↗

    L2COHORTCited in: Diagnosis and Workup
  314. [314]

    Tang X, Li C, Ren J et al.. “Prediction of acute kidney injury after total aortic arch replacement with postoperative serum lactate: a retrospective cohort study.” Renal failure (2026). PMID: 42204447 ↗

    L2COHORTCited in: Diagnosis and Workup
  315. [315]

    Wilson C, Phillips CL, Klenk A et al.. “Crystalglobulinemia causing cutaneous vasculopathy and acute nephropathy in a kidney transplant patient.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 33565232 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup
  316. [316]

    Vanmassenhove J, Kielstein J, Jörres A et al.. “Management of patients at risk of acute kidney injury.” Lancet (London, England) (2017). PMID: 28561005 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup, Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  317. [317]

    Levin A, Tonelli M, Bonventre J et al.. “Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy.” Lancet (London, England) (2017). PMID: 28434650 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup, Prognosis and Natural History, Prevention, Screening & Surveillance
  318. [318]

    Zhang Y, Fu W, Huang X. “Kidney disease after hematopoietic stem cell transplant-treatment standard.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40674058 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  319. [319]

    Herzog CA. “Kidney disease in cardiology.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2010). PMID: 21135041 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup, Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  320. [320]

    Rewa O, Bagshaw SM. “Acute kidney injury-epidemiology, outcomes and economics.” Nature reviews. Nephrology (2014). PMID: 24445744 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup, Prognosis and Natural History, Special Populations & Pregnancy
  321. [321]

    Murugan R, Kellum JA. “Acute kidney injury: what's the prognosis?” Nature reviews. Nephrology (2011). PMID: 21343898 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  322. [322]

    Perazella MA, Markowitz GS. “Drug-induced acute interstitial nephritis.” Nature reviews. Nephrology (2010). PMID: 20517290 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  323. [323]

    Sprangers B, Leaf DE, Porta C et al.. “Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury.” Nature reviews. Nephrology (2022). PMID: 36168055 ↗

    L5REVIEW_NARRATIVECited in: Diagnosis and Workup
  324. [324]

    Sellarés J, de Freitas DG, Mengel M et al.. “Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2011). PMID: 22081892 ↗

    L2OTHERCited in: Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  325. [325]

    Daniel E, Sekulic M, Kudose S et al.. “Kidney allograft biopsy findings after COVID-19.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 34403563 ↗

    L4OTHERCited in: Diagnosis and Workup
  326. [326]

    Halloran PF, Böhmig GA, Bromberg JS et al.. “Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 33107191 ↗

    L4OTHERCited in: Diagnosis and Workup, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  327. [327]

    Eason JD, Gonwa TA, Davis CL et al.. “Proceedings of Consensus Conference on Simultaneous Liver Kidney Transplantation (SLK).” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2008). PMID: 18808402 ↗

    L1OTHERCited in: Diagnosis and Workup, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  328. [328]

    Chen H, Guo Y, You T et al.. “Machine learning models to predict ICU admission of patients with COPD and depression: A retrospective cohort study.” Medicine (2026). PMID: 42363537 ↗

    L2COHORTCited in: Diagnosis and Workup, Complications (Chronic Systemic Sequelae)
  329. [329]

    Guerrero-Romero F, Martínez-Aguilar G, Ríos-Mier M et al.. “Association Between Occult Kidney Disease and COVID-19 Mortality: Evidence from a Retrospective Study.” Iranian journal of kidney diseases (2026). PMID: 42234902 ↗

    L2COHORTCited in: Diagnosis and Workup
  330. [330]

    Weng A, Gardiner S, Pefanis A et al.. “Paroxysmal Cold Haemoglobinuria: A Chilling Case of Acute Renal Failure.” Nephrology (Carlton, Vic.) (2026). PMID: 42383493 ↗

    L4CASE_REPORTCited in: Diagnosis and Workup, Acute Management, Complications (Chronic Systemic Sequelae)
  331. [331]

    Malijan GB, Sardell RJ, Staplin N et al.. “Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 41177216 ↗

    L1RCTCited in: Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, History and Evolution of Treatment
  332. [332]

    Srialluri N, Surapaneni A, Chang A et al.. “Preeclampsia and Long-term Kidney Outcomes: An Observational Cohort Study.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 37516302 ↗

    L2COHORTCited in: Staging and Risk Stratification (KDIGO)
  333. [333]

    Anderson RT, Cleek H, Pajouhi AS et al.. “Prediction of Risk of Death for Patients Starting Dialysis: A Systematic Review and Meta-Analysis.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 31362990 ↗

    L1SR_OBSCited in: Staging and Risk Stratification (KDIGO)
  334. [334]

    Kiernan EA, Hu D, Philbrook HT et al.. “Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 37726051 ↗

    L2TRIAL_NONRANDOMCited in: Staging and Risk Stratification (KDIGO)
  335. [335]

    Lanz J, Kim WK, Walther T et al.. “Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial.” Lancet (London, England) (2019). PMID: 31570258 ↗

    L1RCTCited in: Staging and Risk Stratification (KDIGO), History and Evolution of Treatment
  336. [336]

    Cama-Olivares A, Braun C, Takeuchi T et al.. “Systematic Review and Meta-Analysis of Machine Learning Models for Acute Kidney Injury Risk Classification.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40152939 ↗

    L1SR_OBSCited in: Staging and Risk Stratification (KDIGO)
  337. [337]

    Durando M, Tiu H, Kim JS. “Sulfasalazine-Induced Crystalluria Causing Severe Acute Kidney Injury.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2017). PMID: 28669550 ↗

    L4CASE_REPORTCited in: Staging and Risk Stratification (KDIGO)
  338. [338]

    Kashani KB. “Automated acute kidney injury alerts.” Kidney international (2018). PMID: 29728257 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Prevention, Screening & Surveillance
  339. [339]

    Koyner JL, Garg AX, Coca SG et al.. “Biomarkers predict progression of acute kidney injury after cardiac surgery.” Journal of the American Society of Nephrology : JASN (2012). PMID: 22383693 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO), Long-term and Definitive Management
  340. [340]

    Guo Y, Ni J, Chen S et al.. “MicroRNA-709 Mediates Acute Tubular Injury through Effects on Mitochondrial Function.” Journal of the American Society of Nephrology : JASN (2017). PMID: 29042455 ↗

    L4OTHERCited in: Staging and Risk Stratification (KDIGO)
  341. [341]

    Grams ME, Astor BC, Bash LD et al.. “Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury.” Journal of the American Society of Nephrology : JASN (2010). PMID: 20671214 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO)
  342. [342]

    Xia P, Wen Y, Duan Y et al.. “Clinicopathological Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 with Prolonged Disease Course: A Retrospective Cohort.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32826326 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO)
  343. [343]

    Balasubramanian S, Jansen M, Valerius MT et al.. “Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis.” Journal of the American Society of Nephrology : JASN (2012). PMID: 22343121 ↗

    L5OTHERCited in: Staging and Risk Stratification (KDIGO)
  344. [344]

    Zhang D, Li G, Xu G et al.. “Association of the serum uric acid to high-density lipoprotein cholesterol ratio with in-hospital mortality in patients with acute kidney injury: a retrospective cohort study.” Frontiers in endocrinology (2026). PMID: 42404348 ↗

    L2COHORTCited in: Staging and Risk Stratification (KDIGO), Special Populations & Pregnancy
  345. [345]

    Balkan B, Turan Eİ, Ünal O et al.. “Preoperative Anaemia, Renal Function, and Operative Factors in Acute Kidney Injury and Mortality After Cardiac Surgery with a Prolonged ICU Stay: A Retrospective Cohort Study.” Journal of clinical medicine (2026). PMID: 42355667 ↗

    L2COHORTCited in: Staging and Risk Stratification (KDIGO)
  346. [346]

    Noble RA, Lucas BJ, Selby NM. “Long-Term Outcomes in Patients with Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2020). PMID: 32075806 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  347. [347]

    Renaghan AD, Jaimes EA, Malyszko J et al.. “Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 31836598 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO)
  348. [348]

    Waikar SS, Liu KD, Chertow GM. “Diagnosis, epidemiology and outcomes of acute kidney injury.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18337550 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Complications (Chronic Systemic Sequelae)
  349. [349]

    Kashani K, Rosner MH, Haase M et al.. “Quality Improvement Goals for Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 31101671 ↗

    L5OTHERCited in: Staging and Risk Stratification (KDIGO), Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  350. [350]

    Baumbach A, van Royen N, Amat-Santos IJ et al.. “LANDMARK comparison of early outcomes of newer-generation Myval transcatheter heart valve series with contemporary valves (Sapien and Evolut) in real-world individuals with severe symptomatic native aortic stenosis: a randomised non-inferiority trial.” Lancet (London, England) (2024). PMID: 38795719 ↗

    L1OTHERCited in: Staging and Risk Stratification (KDIGO), Long-term and Definitive Management
  351. [351]

    Mehran R, Owen R, Chiarito M et al.. “A contemporary simple risk score for prediction of contrast-associated acute kidney injury after percutaneous coronary intervention: derivation and validation from an observational registry.” Lancet (London, England) (2021). PMID: 34793743 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO), Prevention, Screening & Surveillance
  352. [352]

    Makkar RR, Cheng W, Waksman R et al.. “Self-expanding intra-annular versus commercially available transcatheter heart valves in high and extreme risk patients with severe aortic stenosis (PORTICO IDE): a randomised, controlled, non-inferiority trial.” Lancet (London, England) (2020). PMID: 32593323 ↗

    L1OTHERCited in: Staging and Risk Stratification (KDIGO)
  353. [353]

    Herzog CA. “Kidney disease in cardiology.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2007). PMID: 18079149 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Prognosis and Natural History, Prevention, Screening & Surveillance
  354. [354]

    Sawhney S, Ball W, Bell S et al.. “Recovery of kidney function after acute kidney disease-a multi-cohort analysis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 37573145 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO)
  355. [355]

    Raymakers-Janssen PAMA, Leitzinger N, van den Berg G et al.. “Nephrotoxicity and kidney outcomes in pediatric oncology patients.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 40844823 ↗

    L3OTHERCited in: Staging and Risk Stratification (KDIGO), History and Evolution of Treatment
  356. [356]

    Gama RM, Clark K, Bhaduri M et al.. “Acute kidney injury e-alerts in pregnancy: rates, recognition and recovery.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021). PMID: 33089321 ↗

    L3OTHERCited in: Staging and Risk Stratification (KDIGO)
  357. [357]

    Schunk SJ, Speer T, Petrakis I et al.. “Dickkopf 3-a novel biomarker of the 'kidney injury continuum'.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021). PMID: 32025732 ↗

    L5OTHERCited in: Staging and Risk Stratification (KDIGO)
  358. [358]

    Diaz J, Lidon L, Sauri I et al.. “The impact of acute kidney damage in the community.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 39049453 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO)
  359. [359]

    Eckardt KU, Kasiske BL. “Kidney disease: improving global outcomes.” Nature reviews. Nephrology (2009). PMID: 19786993 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO)
  360. [360]

    Bruchfeld A. “The COVID-19 pandemic: consequences for nephrology.” Nature reviews. Nephrology (2021). PMID: 33257872 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  361. [361]

    Chronopoulos A, Cruz DN, Ronco C. “Hospital-acquired acute kidney injury in the elderly.” Nature reviews. Nephrology (2010). PMID: 20125094 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Renal Replacement Therapy, Dialysis Access & Transplantation
  362. [362]

    Chan TM. “Treatment of severe lupus nephritis: the new horizon.” Nature reviews. Nephrology (2014). PMID: 25421826 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO), Long-term and Definitive Management
  363. [363]

    Ricci Z, Cruz DN, Ronco C. “Classification and staging of acute kidney injury: beyond the RIFLE and AKIN criteria.” Nature reviews. Nephrology (2011). PMID: 21364520 ↗

    L5REVIEW_NARRATIVECited in: Staging and Risk Stratification (KDIGO)
  364. [364]

    Kreepala C, Famulski KS, Chang J et al.. “Comparing molecular assessment of implantation biopsies with histologic and demographic risk assessment.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2013). PMID: 23282320 ↗

    L2OTHERCited in: Staging and Risk Stratification (KDIGO)
  365. [365]

    Robinson CH, Jeyakumar N, Luo B et al.. “Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34039667 ↗

    L3COHORTCited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  366. [366]

    Vazquez MA, Oliver G, Amarasingham R et al.. “Pragmatic Trial of Hospitalization Rate in Chronic Kidney Disease.” The New England journal of medicine (2024). PMID: 38598574 ↗

    L1RCTCited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  367. [367]

    Parapiboon W, Tatiyanupanwong S, Khositrangsikun K et al.. “Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury: A Randomized Controlled Trial.” Clinical journal of the American Society of Nephrology : CJASN (2024). PMID: 38809614 ↗

    L1RCTCited in: Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Prognosis and Natural History, Special Populations & Pregnancy
  368. [368]

    Castellano G, Intini A, Stasi A et al.. “Complement Modulation of Anti-Aging Factor Klotho in Ischemia/Reperfusion Injury and Delayed Graft Function.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015). PMID: 26280899 ↗

    L5RCTCited in: Acute Management, Long-term and Definitive Management, History and Evolution of Treatment
  369. [369]

    Zarbock A, Forni LG, Ostermann M et al.. “Designing acute kidney injury clinical trials.” Nature reviews. Nephrology (2023). PMID: 37653237 ↗

    L5TRIAL_NONRANDOMCited in: Acute Management
  370. [370]

    Wolfkind IB, Geftos LT, Mitchell WK et al.. “Dexmedetomidine versus usual care in adult patients with septic shock receiving vasopressors: A systematic review and meta-analysis of randomised controlled trials.” European journal of anaesthesiology and intensive care (2026). PMID: 42244837 ↗

    L1SR_MA_RCTCited in: Acute Management
  371. [371]

    Yarandi N, Shirali AC. “Onconephrology: Core Curriculum 2023.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 37855786 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Long-term and Definitive Management
  372. [372]

    Teixeira JP, Hiremath S, Kabli AO et al.. “Continuous Kidney Replacement Therapies: Core Curriculum 2025.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 40072400 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Prognosis and Natural History
  373. [373]

    Roehm B, Vest AR, Weiner DE. “Left Ventricular Assist Devices, Kidney Disease, and Dialysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2017). PMID: 29249390 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  374. [374]

    Allegretti AS, Solà E, Ginès P. “Clinical Application of Kidney Biomarkers in Cirrhosis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 32622560 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  375. [375]

    Heung M. “Outpatient Dialysis for Acute Kidney Injury: Progress and Pitfalls.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2019). PMID: 31204193 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  376. [376]

    Kaushal GP, Shah SV. “Challenges and advances in the treatment of AKI.” Journal of the American Society of Nephrology : JASN (2014). PMID: 24480828 ↗

    L5REVIEW_NARRATIVECited in: Acute Management
  377. [377]

    Perico N, Casiraghi F, Remuzzi G. “Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology.” Journal of the American Society of Nephrology : JASN (2017). PMID: 29191959 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History, Special Populations & Pregnancy
  378. [378]

    Mohmand H, Goldfarb S. “Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome.” Journal of the American Society of Nephrology : JASN (2011). PMID: 21310818 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  379. [379]

    Hryciw N, Joannidis M, Hiremath S et al.. “Intravenous Albumin for Mitigating Hypotension and Augmenting Ultrafiltration during Kidney Replacement Therapy.” Clinical journal of the American Society of Nephrology : CJASN (2020). PMID: 33115729 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  380. [380]

    Abadeer K, Aslam N, Cortese C et al.. “Cytomegalovirus-Induced Polyarteritis Nodosa in a Liver Transplant Recipient.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2017). PMID: 28556523 ↗

    L4CASE_REPORTCited in: Acute Management, Long-term and Definitive Management
  381. [381]

    Mehta RL, Burdmann EA, Cerdá J et al.. “Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study.” Lancet (London, England) (2016). PMID: 27086173 ↗

    L4OTHERCited in: Acute Management
  382. [382]

    Wong J, Vilar E, Davenport A et al.. “Incremental haemodialysis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 26038351 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History, Special Populations & Pregnancy
  383. [383]

    Ema C, Iwakura T, Tsuji N et al.. “Teneligliptin and empagliflozin attenuate ferroptosis-mediated acute tubular injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 41042250 ↗

    L5OTHERCited in: Acute Management, Long-term and Definitive Management, Prevention, Screening & Surveillance
  384. [384]

    Bakkaloğlu SA, Delibaş A, Sürmeli Döven S et al.. “Pediatric kidney care experience after the 2023 Türkiye earthquake.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38327222 ↗

    L4OTHERCited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  385. [385]

    Ishimoto Y, Inagi R. “Mitochondria: a therapeutic target in acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 26333547 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Long-term and Definitive Management
  386. [386]

    Corradi F, Bell M, De Rosa S. “Kidney Doppler ultrasonography in critical care nephrology.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38697934 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, History and Evolution of Treatment
  387. [387]

    Metzinger-Le Meuth V, Fourdinier O, Charnaux N et al.. “The expanding roles of microRNAs in kidney pathophysiology.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2019). PMID: 29800482 ↗

    L5REVIEW_NARRATIVECited in: Acute Management
  388. [388]

    Nøsted SB, Falkvist FS, Schønemann-Lund M et al.. “The Impact of Diuretics on Mortality in Acute Kidney Injury With or Without Fluid Accumulation in Intensive Care-A Retrospective Cohort Study.” Acta anaesthesiologica Scandinavica (2026). PMID: 42374647 ↗

    L2COHORTCited in: Acute Management, Long-term and Definitive Management, Prognosis and Natural History
  389. [389]

    Weng NC, Huang YT, Wu JY. “Alcohol use disorder and long-term kidney outcomes after acute kidney disease: a retrospective cohort study.” The American journal of drug and alcohol abuse (2026). PMID: 42258628 ↗

    L2COHORTCited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  390. [390]

    Sever MS, Luyckx V, Tonelli M et al.. “Disasters and kidney care: pitfalls and solutions.” Nature reviews. Nephrology (2023). PMID: 37479903 ↗

    L5REVIEW_NARRATIVECited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History, Special Populations & Pregnancy
  391. [391]

    Tuuminen R, Nykänen AI, Saharinen P et al.. “Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2013). PMID: 23773358 ↗

    L5OTHERCited in: Acute Management, Long-term and Definitive Management, Prevention, Screening & Surveillance
  392. [392]

    Kayler LK, Garzon P, Magliocca J et al.. “Outcomes and utilization of kidneys from deceased donors with acute kidney injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2009). PMID: 19178415 ↗

    L2OTHERCited in: Acute Management, Long-term and Definitive Management
  393. [393]

    Lan J, Mao Y, Shi C et al.. “Regional citrate versus systemic heparin anticoagulation in continuous renal replacement therapy for sepsis-associated acute kidney injury: A retrospective cohort study of short-term outcomes.” The Journal of international medical research (2026). PMID: 42383899 ↗

    L2COHORTCited in: Acute Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  394. [394]

    Chao Y, Liu Q, Li A et al.. “Severe Methotrexate toxicity after ectopic pregnancy: a case report managed with continuous renal replacement therapy.” Cancer chemotherapy and pharmacology (2026). PMID: 42301427 ↗

    L4CASE_REPORTCited in: Acute Management, Long-term and Definitive Management
  395. [395]

    Zhang HD, Gao Y, Zhang ZY et al.. “The Effect of Dexmedetomidine on Postoperative Acute Kidney Injury in High-Risk Partial Nephrectomy Patients: A Retrospective Cohort Study.” Drug design, development and therapy (2026). PMID: 42238708 ↗

    L2COHORTCited in: Acute Management
  396. [396]

    Tong A, Chando S, Crowe S et al.. “Research priority setting in kidney disease: a systematic review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2015). PMID: 25582284 ↗

    L5SR_OBSCited in: Long-term and Definitive Management
  397. [397]

    Krisanapan P, Vongsanim S, Pin-On P et al.. “Efficacy of Furosemide, Oral Sodium Chloride, and Fluid Restriction for Treatment of Syndrome of Inappropriate Antidiuresis (SIAD): An Open-label Randomized Controlled Study (The EFFUSE-FLUID Trial).” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 32199708 ↗

    L1RCTCited in: Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, History and Evolution of Treatment, Special Populations & Pregnancy
  398. [398]

    Zhao M, Sun S, Huang Z et al.. “Network Meta-Analysis of Novel Glucose-Lowering Drugs on Risk of Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2020). PMID: 33376101 ↗

    L1SR_OBSCited in: Long-term and Definitive Management
  399. [399]

    Swaminathan M, Stafford-Smith M, Chertow GM et al.. “Allogeneic Mesenchymal Stem Cells for Treatment of AKI after Cardiac Surgery.” Journal of the American Society of Nephrology : JASN (2017). PMID: 29038286 ↗

    L1RCTCited in: Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment
  400. [400]

    Peel TN, Astbury S, Cheng AC et al.. “Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty.” The New England journal of medicine (2023). PMID: 37851875 ↗

    L1RCTCited in: Long-term and Definitive Management
  401. [401]

    Myles PS, Bellomo R, Corcoran T et al.. “Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery.” The New England journal of medicine (2018). PMID: 29742967 ↗

    L1RCTCited in: Long-term and Definitive Management, Prognosis and Natural History
  402. [402]

    . “Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial.” Lancet (London, England) (2026). PMID: 42309115 ↗

    L1RCTCited in: Long-term and Definitive Management, History and Evolution of Treatment
  403. [403]

    Burdet C, Saïdani N, Dupieux C et al.. “Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial.” Lancet (London, England) (2025). PMID: 41115439 ↗

    L1RCTCited in: Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Prognosis and Natural History, Special Populations & Pregnancy
  404. [404]

    Mohebbi N, Ritter A, Wiegand A et al.. “Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.” Lancet (London, England) (2023). PMID: 36708734 ↗

    L1RCTCited in: Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Special Populations & Pregnancy
  405. [405]

    Lichtenberger FB, Xu M, Erdoğan C et al.. “Activating soluble guanylyl cyclase attenuates ischemic kidney damage.” Kidney international (2024). PMID: 39571904 ↗

    L5OTHERCited in: Long-term and Definitive Management, Prevention, Screening & Surveillance
  406. [406]

    Li F, Lan Q, Wang Y et al.. “Single-cell analysis of proximal tubular cells with different DNA content reveals functional heterogeneity in the acute kidney injury to chronic kidney disease transition.” Kidney international (2025). PMID: 40268163 ↗

    L5OTHERCited in: Long-term and Definitive Management, History and Evolution of Treatment
  407. [407]

    Mimura I, Chen Z, Natarajan R. “Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes.” Kidney international (2024). PMID: 39725223 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  408. [408]

    Panchapakesan U, Pollock C. “Drug repurposing in kidney disease.” Kidney international (2018). PMID: 29628139 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  409. [409]

    Decuypere JP, Ceulemans LJ, Agostinis P et al.. “Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2015). PMID: 26169721 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History, Special Populations & Pregnancy
  410. [410]

    Hogan JJ, Alexander MP, Leung N. “Dysproteinemia and the Kidney: Core Curriculum 2019.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2019). PMID: 31331759 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  411. [411]

    Kant S, Kronbichler A, Geetha D. “Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2022). PMID: 35440396 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  412. [412]

    Maremonti F, Meyer C, Linkermann A. “Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss.” Journal of the American Society of Nephrology : JASN (2022). PMID: 35022311 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  413. [413]

    Anders HJ. “Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease.” Journal of the American Society of Nephrology : JASN (2016). PMID: 27516236 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, History and Evolution of Treatment
  414. [414]

    Sharma S, Leaf DE. “Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention.” Journal of the American Society of Nephrology : JASN (2019). PMID: 31554656 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Prevention, Screening & Surveillance
  415. [415]

    Kumar S, Allen DA, Kieswich JE et al.. “Dexamethasone ameliorates renal ischemia-reperfusion injury.” Journal of the American Society of Nephrology : JASN (2009). PMID: 19797168 ↗

    L5OTHERCited in: Long-term and Definitive Management
  416. [416]

    Lieberthal W, Levine JS. “The role of the mammalian target of rapamycin (mTOR) in renal disease.” Journal of the American Society of Nephrology : JASN (2009). PMID: 19875810 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, History and Evolution of Treatment, Prognosis and Natural History
  417. [417]

    Molitoris BA, Dagher PC, Sandoval RM et al.. “siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury.” Journal of the American Society of Nephrology : JASN (2009). PMID: 19470675 ↗

    L5OTHERCited in: Long-term and Definitive Management, History and Evolution of Treatment
  418. [418]

    Hosoya T, Uchida S, Shibata S et al.. “Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice.” Journal of the American Society of Nephrology : JASN (2021). PMID: 34799437 ↗

    L5OTHERCited in: Long-term and Definitive Management
  419. [419]

    DeWeese TL, Manzanera A, Sylvester J et al.. “Aglatimagene besadenovec (CAN-2409) with radiotherapy for patients with localised prostate cancer: a phase 3, multicentre, randomised, double-blind, placebo-controlled trial.” The Lancet. Oncology (2026). PMID: 42225101 ↗

    L1RCTCited in: Long-term and Definitive Management
  420. [420]

    Elenjickal EJ, Baroz F, Boileau P et al.. “The Effect of Canagliflozin Dose on Renal and Cardiovascular Outcomes in Type 2 Diabetes and High Cardiovascular Risk.” Diabetes, obesity & metabolism (2026). PMID: 42219264 ↗

    L2RCTCited in: Long-term and Definitive Management
  421. [421]

    Alkandari O, Nguyen L, Hebert D et al.. “Acute Kidney Injury in Children with Kidney Transplantation.” Clinical journal of the American Society of Nephrology : CJASN (2018). PMID: 30242029 ↗

    L2OTHERCited in: Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  422. [422]

    Kalantar-Zadeh K, Jafar TH, Nitsch D et al.. “Chronic kidney disease.” Lancet (London, England) (2021). PMID: 34175022 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  423. [423]

    Nakao Y, Mori M, Mori Y et al.. “SGLT2 inhibitors and acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 40736512 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prevention, Screening & Surveillance
  424. [424]

    Boor P, Ostendorf T, Floege J. “PDGF and the progression of renal disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 24493869 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  425. [425]

    Chen Z, Chen C, Lai K et al.. “GSDMD and GSDME synergy in the transition of acute kidney injury to chronic kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38244230 ↗

    L5OTHERCited in: Long-term and Definitive Management
  426. [426]

    Sanz AB, Izquierdo MC, Sanchez-Niño MD et al.. “TWEAK and the progression of renal disease: clinical translation.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 24493870 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  427. [427]

    Fontecha-Barriuso M, Martin-Sanchez D, Ruiz-Andres O et al.. “Targeting epigenetic DNA and histone modifications to treat kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2018). PMID: 29534238 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  428. [428]

    Kellum JA, Chawla LS. “Cell-cycle arrest and acute kidney injury: the light and the dark sides.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 26044835 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  429. [429]

    Ronco C, Rizo-Topete L, Serrano-Soto M et al.. “Pro: Prevention of acute kidney injury: time for teamwork and new biomarkers.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 28375502 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Prevention, Screening & Surveillance
  430. [430]

    Delaye M, Matte P, Mouren A et al.. “Acute kidney injury in patients included in early-phase oncology clinical trials, results of the AKITEP study.” European journal of cancer (Oxford, England : 1990) (2026). PMID: 42203588 ↗

    L4TRIAL_NONRANDOMCited in: Long-term and Definitive Management
  431. [431]

    Tang C, Livingston MJ, Safirstein R et al.. “Cisplatin nephrotoxicity: new insights and therapeutic implications.” Nature reviews. Nephrology (2022). PMID: 36229672 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  432. [432]

    van der Aart-van der Beek AB, de Boer RA, Heerspink HJL. “Kidney and heart failure outcomes associated with SGLT2 inhibitor use.” Nature reviews. Nephrology (2022). PMID: 35145275 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  433. [433]

    Meng XM, Wang L, Nikolic-Paterson DJ et al.. “Innate immune cells in acute and chronic kidney disease.” Nature reviews. Nephrology (2025). PMID: 40263532 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  434. [434]

    Jansen MPB, Florquin S, Roelofs JJTH. “The role of platelets in acute kidney injury.” Nature reviews. Nephrology (2018). PMID: 29760447 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  435. [435]

    Izzedine H, Harris M, Perazella MA. “The nephrotoxic effects of HAART.” Nature reviews. Nephrology (2009). PMID: 19776778 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management, Prognosis and Natural History
  436. [436]

    Ganguli A, Sawinski D, Berns JS. “Kidney diseases associated with haematological cancers.” Nature reviews. Nephrology (2015). PMID: 26035773 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  437. [437]

    Schunk SJ, Floege J, Fliser D et al.. “WNT-β-catenin signalling - a versatile player in kidney injury and repair.” Nature reviews. Nephrology (2020). PMID: 32989282 ↗

    L5REVIEW_NARRATIVECited in: Long-term and Definitive Management
  438. [438]

    Bossini N, Alberici F, Delbarba E et al.. “Kidney transplant patients with SARS-CoV-2 infection: The Brescia Renal COVID task force experience.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32627319 ↗

    L4OTHERCited in: Long-term and Definitive Management, Renal Replacement Therapy, Dialysis Access & Transplantation
  439. [439]

    Kamal AI, Doppalapudi H, Ho T et al.. “Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.” Renal failure (2026). PMID: 42310940 ↗

    L4CASE_REPORTCited in: Long-term and Definitive Management, Complications (Chronic Systemic Sequelae)
  440. [440]

    Zhang Q, Wu J, Meng F et al.. “Long-term complete remission and minimal side effects after CD19/CD22 CAR-T cell cocktail therapy in a living donor with DLBCL: A rare case report.” Cell transplantation (2026). PMID: 42231134 ↗

    L4CASE_REPORTCited in: Long-term and Definitive Management
  441. [441]

    Sobotka O, Staňková P, Fortunato J et al.. “Diagnosing Metformin Intoxication with High-Resolution Platelet Respirometry: A Case Report.” International journal of molecular sciences (2026). PMID: 42196606 ↗

    L4CASE_REPORTCited in: Long-term and Definitive Management, Fluid, Electrolyte & Acid-Base Disorders
  442. [442]

    Yow BLH, Kittaka RC, Yeung CSJ. “Discordant ANCA Positivity in Immune Complex Glomerulonephritis Secondary to Bartonella henselae Prosthetic Valve Endocarditis.” Nephrology (Carlton, Vic.) (2026). PMID: 42168832 ↗

    L4CASE_REPORTCited in: Long-term and Definitive Management
  443. [443]

    Song SH, Lee S, Ryu JH et al.. “Safety of additional intravenous acetaminophen/ibuprofen administration in patients undergoing robot-assisted renal surgery with postoperative ketorolac-based patient-controlled analgesia: A retrospective propensity-score-matched analysis.” Investigative and clinical urology (2026). PMID: 42405712 ↗

    L2OTHERCited in: Long-term and Definitive Management
  444. [444]

    Ku E, Copeland TP, McCulloch CE et al.. “Intensive Home Blood Pressure Lowering in Patients With Advanced CKD.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2024). PMID: 39427725 ↗

    L1RCTCited in: Fluid, Electrolyte & Acid-Base Disorders, History and Evolution of Treatment
  445. [445]

    Bellomo R, Cass A, Cole L et al.. “Intensity of continuous renal-replacement therapy in critically ill patients.” The New England journal of medicine (2009). PMID: 19846848 ↗

    L1RCTCited in: Fluid, Electrolyte & Acid-Base Disorders
  446. [446]

    Whitlock R, Leon SJ, Manacsa H et al.. “The association between dual RAAS inhibition and risk of acute kidney injury and hyperkalemia in patients with diabetic kidney disease: a systematic review and meta-analysis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 37309038 ↗

    L1SR_OBSCited in: Fluid, Electrolyte & Acid-Base Disorders
  447. [447]

    Hwang YJ, Muanda FT, McArthur E et al.. “Trimethoprim-sulfamethoxazole and the risk of a hospital encounter with hyperkalemia: a matched population-based cohort study.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 36208171 ↗

    L2COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  448. [448]

    Ascher SB, Scherzer R, Estrella MM et al.. “Kidney tubule health, mineral metabolism and adverse events in persons with CKD in SPRINT.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 34473302 ↗

    L2TRIAL_NONRANDOMCited in: Fluid, Electrolyte & Acid-Base Disorders
  449. [449]

    Manohar S, Kompotiatis P, Thongprayoon C et al.. “Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2019). PMID: 29762725 ↗

    L2SR_OBSCited in: Fluid, Electrolyte & Acid-Base Disorders
  450. [450]

    Portales-Castillo I, Mount DB, Nigwekar SU et al.. “Zoledronic Acid-Associated Fanconi Syndrome in Patients With Cancer.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2022). PMID: 35219759 ↗

    L4CASE_REPORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  451. [451]

    Devoti E, Marta E, Belotti E et al.. “Diethylene glycol poisoning from transcutaneous absorption.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2014). PMID: 25445099 ↗

    L4CASE_REPORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  452. [452]

    Adebamiro A, Perazella MA. “Recurrent acute kidney injury following bath salts intoxication.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2011). PMID: 22119408 ↗

    L4CASE_REPORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  453. [453]

    Cerdá J, Tolwani AJ, Warnock DG. “Critical care nephrology: management of acid-base disorders with CRRT.” Kidney international (2011). PMID: 21814173 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  454. [454]

    Bagshaw SM, Wald R. “Strategies for the optimal timing to start renal replacement therapy in critically ill patients with acute kidney injury.” Kidney international (2017). PMID: 28222898 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  455. [455]

    Abu-Alfa AK, Younes A. “Tumor lysis syndrome and acute kidney injury: evaluation, prevention, and management.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2010). PMID: 20420966 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  456. [456]

    Mclean A, Nath M, Sawhney S. “Population Epidemiology of Hyperkalemia: Cardiac and Kidney Long-term Health Outcomes.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34419518 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  457. [457]

    Mullins ME, Kraut JA. “The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34895948 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  458. [458]

    Al-Aly Z, Maddukuri G, Xie Y. “Proton Pump Inhibitors and the Kidney: Implications of Current Evidence for Clinical Practice and When and How to Deprescribe.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2019). PMID: 31606235 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  459. [459]

    Tear AA, Fauziah N, Riswari SF et al.. “Prognostic factors in malaria patients with acute kidney injury: a systematic review and meta analysis.” Renal failure (2026). PMID: 42185742 ↗

    L2SR_OBSCited in: Fluid, Electrolyte & Acid-Base Disorders
  460. [460]

    Bugarski M, Ghazi S, Polesel M et al.. “Changes in NAD and Lipid Metabolism Drive Acidosis-Induced Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2021). PMID: 33478973 ↗

    L5OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  461. [461]

    Pannu N, McBrien KA, Tan Z et al.. “Advancing Community Care and Access to Follow-Up after Acute Kidney Injury Hospitalization: A Randomized Clinical Trial.” Journal of the American Society of Nephrology : JASN (2024). PMID: 39446571 ↗

    L1OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  462. [462]

    Peng W, Shang X, Zhang C et al.. “Long-term efficacy and renal safety of SGLT2 inhibitors in patients with heart failure and advanced chronic kidney disease (stage 4): a propensity score-matched retrospective cohort study.” Frontiers in cardiovascular medicine (2026). PMID: 42389639 ↗

    L2COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders, History and Evolution of Treatment
  463. [463]

    Campbell GA, Rosner MH. “The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18684895 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  464. [464]

    Saville J, Moore LW, Narasaki Y et al.. “Kidney Nutrition for Value-Based Care Models: The Role of Low Protein Diets and Keto-Analogue Supplementation to Delay Dialysis.” Clinical journal of the American Society of Nephrology : CJASN (2025). PMID: 40932799 ↗

    L5OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  465. [465]

    Fukagawa M. “Nephrology in earthquakes: sharing experiences and information.” Clinical journal of the American Society of Nephrology : CJASN (2007). PMID: 17699497 ↗

    L5OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  466. [466]

    Vaara ST, Reinikainen M, Wald R et al.. “Timing of RRT based on the presence of conventional indications.” Clinical journal of the American Society of Nephrology : CJASN (2014). PMID: 25107952 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  467. [467]

    Chang TI, Zheng Y, Montez-Rath ME et al.. “Antihypertensive Medication Use in Older Patients Transitioning from Chronic Kidney Disease to End-Stage Renal Disease on Dialysis.” Clinical journal of the American Society of Nephrology : CJASN (2016). PMID: 27354656 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  468. [468]

    Knechtle B, Scheer V, Nikolaidis PT et al.. “The Comrades Marathon: a narrative review of physiological responses and health implications in the world's oldest ultra-marathon.” Frontiers in physiology (2026). PMID: 42232809 ↗

    L5SR_OBSCited in: Fluid, Electrolyte & Acid-Base Disorders
  469. [469]

    Gungor O, Aydin Z, Inci A et al.. “Seizures in patients with kidney diseases: a neglected problem?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 34596683 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders, Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  470. [470]

    Bonavia A, Stiles N. “Renohepatic crosstalk: a review of the effects of acute kidney injury on the liver.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 33527986 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  471. [471]

    Di Mario F, Sabatino A, Regolisti G et al.. “Simplified regional citrate anticoagulation protocol for CVVH, CVVHDF and SLED focused on the prevention of KRT-related hypophosphatemia while optimizing acid-base balance.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 37037771 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  472. [472]

    Di Mario F, Regolisti G, Maggiore U et al.. “Hypophosphatemia in critically ill patients undergoing Sustained Low-Efficiency Dialysis with standard dialysis solutions.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 35481705 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  473. [473]

    Nash DM, Markle-Reid M, Brimble KS et al.. “Nonsteroidal anti-inflammatory drug use and risk of acute kidney injury and hyperkalemia in older adults: a population-based study.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2019). PMID: 31264694 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  474. [474]

    Alves SC, Tomasi CD, Constantino L et al.. “Hypomagnesemia as a risk factor for the non-recovery of the renal function in critically ill patients with acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2012). PMID: 22764195 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  475. [475]

    Demirjian S, Teo BW, Guzman JA et al.. “Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2011). PMID: 21382993 ↗

    L2OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  476. [476]

    Kan WC, Wang HY, Chien CC et al.. “Intermediate bioelectrolyte changes after phospho-soda or polyethylene glycol precolonoscopic laxatives in a population undergoing health examinations.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2011). PMID: 21617195 ↗

    L3OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  477. [477]

    Jones J, Colven RB, Morrisette T et al.. “Assessment of treatment outcomes in patients receiving high- versus low-dose sulfamethoxazole-trimethoprim for oral stepdown therapy in gram-negative bacteremia: a multi-center, retrospective cohort study.” Antimicrobial stewardship & healthcare epidemiology : ASHE (2026). PMID: 42375668 ↗

    L3COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  478. [478]

    Tian G, Lin Z, Chen Z et al.. “Association between renal replacement therapy and in-hospital mortality in patients with severe acute kidney injury: a retrospective cohort study based on MIMIC-IV database.” BMC urology (2026). PMID: 42226256 ↗

    L3COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  479. [479]

    Meng X, Qiu C, Huang H et al.. “Sodium bicarbonate therapy for metabolic acidosis in children stratified by acute kidney injury status and chloride levels: a retrospective cohort study.” Translational pediatrics (2026). PMID: 42158658 ↗

    L3COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  480. [480]

    Pérez-Mir M, Canal Girol C, Escolà-Vergé L et al.. “Antibiotic Tolerability in Nocardia Infection Among Kidney Transplant Recipients: A Multicenter Cohort Study.” Transplant infectious disease : an official journal of the Transplantation Society (2026). PMID: 42142207 ↗

    L3COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  481. [481]

    Better OS, Abassi ZA. “Early fluid resuscitation in patients with rhabdomyolysis.” Nature reviews. Nephrology (2011). PMID: 21587227 ↗

    L5REVIEW_NARRATIVECited in: Fluid, Electrolyte & Acid-Base Disorders
  482. [482]

    Toto RD. “RAS blockade, hyperkalemia and AKI--look and you will find.” Nature reviews. Nephrology (2012). PMID: 22473512 ↗

    L5OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  483. [483]

    Rhee CM, Kalantar-Zadeh K. “Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.” Nature reviews. Nephrology (2017). PMID: 28736433 ↗

    L5OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  484. [484]

    Zhang Y, Hu J, Liu J et al.. “Early continuous renal replacement therapy for acute kidney injury in a very low birth weight infant: a case report and literature review.” Frontiers in medicine (2026). PMID: 42396159 ↗

    L4CASE_REPORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  485. [485]

    Wei W, Jiaming W, Tongping S. “Serum magnesium and adverse prognosis in acute pancreatitis with acute kidney injury: a MIMIC-IV retrospective study.” Scientific reports (2026). PMID: 42362664 ↗

    L3COHORTCited in: Fluid, Electrolyte & Acid-Base Disorders
  486. [486]

    Luppes VAC, Pamir Z, Blom NA et al.. “Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass.” European journal of pediatrics (2026). PMID: 42429980 ↗

    L3OTHERCited in: Fluid, Electrolyte & Acid-Base Disorders
  487. [487]

    Jun M, Heerspink HJ, Ninomiya T et al.. “Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis.” Clinical journal of the American Society of Nephrology : CJASN (2010). PMID: 20395356 ↗

    L1SR_OBSCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  488. [488]

    Lachance P, Villeneuve PM, Rewa OG et al.. “Association between e-alert implementation for detection of acute kidney injury and outcomes: a systematic review.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2017). PMID: 28088774 ↗

    L2SR_OBSCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  489. [489]

    Kremer D, Pieters TT, Verhaar MC et al.. “A systematic review and meta-analysis of COVID-19 in kidney transplant recipients: Lessons to be learned.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 34212499 ↗

    L2SR_OBSCited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  490. [490]

    Pefanis A, Ierino FL, Murphy JM et al.. “Regulated necrosis in kidney ischemia-reperfusion injury.” Kidney international (2019). PMID: 31005270 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  491. [491]

    Nakamura Y, Inoue T. “Tolerogenic dendritic cells: promising cell therapy for acute kidney injury.” Kidney international (2023). PMID: 37599014 ↗

    L5OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  492. [492]

    Gibney RT, Sever MS, Vanholder RC. “Disaster nephrology: crush injury and beyond.” Kidney international (2013). PMID: 24107850 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  493. [493]

    Niyyar VD, O'Neill WC. “Point-of-care ultrasound in the practice of nephrology.” Kidney international (2018). PMID: 29477241 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  494. [494]

    Linkermann A. “Nonapoptotic cell death in acute kidney injury and transplantation.” Kidney international (2016). PMID: 26759047 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  495. [495]

    Davenport A, Sheikh MF, Lamb E et al.. “Acute kidney injury in acute-on-chronic liver failure: where does hepatorenal syndrome fit?” Kidney international (2017). PMID: 28844314 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  496. [496]

    Asowata EO, Romoli S, Sargeant R et al.. “Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.” Kidney international (2024). PMID: 38431215 ↗

    L4OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  497. [497]

    Slagle C, Askenazi D, Starr M. “Recent Advances in Kidney Replacement Therapy in Infants: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 38147895 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  498. [498]

    Alasfar S, Koubar SH, Gautam SC et al.. “Kidney Care in Times of Crises: A Review.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2024). PMID: 38851445 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  499. [499]

    Bouchard J, Mehta RL. “Timing of Kidney Support Therapy in Acute Kidney Injury: What Are We Waiting For?” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34461167 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Prognosis and Natural History
  500. [500]

    Fiaccadori E, Antonucci E, Morabito S et al.. “Colistin Use in Patients With Reduced Kidney Function.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2016). PMID: 27160031 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment
  501. [501]

    Rudnick MR, Leonberg-Yoo AK, Litt HI et al.. “The Controversy of Contrast-Induced Nephropathy With Intravenous Contrast: What Is the Risk?” American journal of kidney diseases : the official journal of the National Kidney Foundation (2019). PMID: 31473019 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  502. [502]

    Hildebrand AM, Liu K, Shariff SZ et al.. “Characteristics and Outcomes of AKI Treated with Dialysis during Pregnancy and the Postpartum Period.” Journal of the American Society of Nephrology : JASN (2015). PMID: 25977311 ↗

    L4OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  503. [503]

    Gupta S, Coca SG, Chan L et al.. “AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.” Journal of the American Society of Nephrology : JASN (2020). PMID: 33067383 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  504. [504]

    Liu J, Kumar S, Heinzel A et al.. “Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32034106 ↗

    L5OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  505. [505]

    Waikar SS, Betensky RA, Emerson SC et al.. “Imperfect gold standards for kidney injury biomarker evaluation.” Journal of the American Society of Nephrology : JASN (2011). PMID: 22021710 ↗

    L5OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  506. [506]

    Cho KC, Himmelfarb J, Paganini E et al.. “Survival by dialysis modality in critically ill patients with acute kidney injury.” Journal of the American Society of Nephrology : JASN (2006). PMID: 17021268 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  507. [507]

    Wang CA, Wang WJ, Chen JY et al.. “Impact of sodium-glucose cotransporter-2 inhibitors on clinical outcomes in patients with type 1 diabetes after dialysis-requiring acute kidney injury: a real-world cohort study.” Diabetes research and clinical practice (2026). PMID: 42049097 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  508. [508]

    Murugan R, Talisa V, Chang CH et al.. “Alternative net ultrafiltration rate strategies in acute kidney injury: a feasibility randomized clinical trial.” Critical care (London, England) (2026). PMID: 42021350 ↗

    L1RCTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  509. [509]

    Okazawa Y, Yoshida S, Miyake K et al.. “Acute normovolemic hemodilution and cardiac surgery-associated acute kidney injury: a retrospective cohort study.” Canadian journal of anaesthesia = Journal canadien d'anesthesie (2026). PMID: 41986594 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  510. [510]

    Alkhezi O, Alfehaid L, Alanezi A et al.. “Real-world use of semaglutide in patients with type 2 diabetes and end-stage renal disease: a multicenter retrospective cohort study.” Frontiers in endocrinology (2026). PMID: 41970978 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  511. [511]

    Maji C, Kokiwar PR, Biradar A et al.. “Comment on "Trajectory pattern of serum urea nitrogen to creatinine ratio in acute kidney injury requiring continuous renal replacement therapy: A post hoc analysis of a retrospective multicenter cohort study".” Journal of critical care (2026). PMID: 41932215 ↗

    L5COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  512. [512]

    Bellomo R, Ankawi G, Bagshaw SM et al.. “Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024). PMID: 38621759 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  513. [513]

    Dolan KJ, Gist KM, Basalely A et al.. “Functional outcomes in pediatric patients on renal replacement therapy in a worldwide registry.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 40258340 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  514. [514]

    Genovesi S, Regolisti G, Burlacu A et al.. “The conundrum of the complex relationship between acute kidney injury and cardiac arrhythmias.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 35777072 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  515. [515]

    Vanderlinden JA, Semrau JS, Silver SA et al.. “Acute kidney injury is associated with subtle but quantifiable neurocognitive impairments.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 33881540 ↗

    L3OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  516. [516]

    Deja A, Deja K, Cappoli A et al.. “Predicting mortality and short-term outcomes of continuous kidney replacement therapies in neonates and infants.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 40862677 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  517. [517]

    Hundemer GL, Srivastava A, Jacob KA et al.. “Acute kidney injury in renal transplant recipients undergoing cardiac surgery.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021). PMID: 32892219 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  518. [518]

    Guzzo I, de Galasso L, Bayazit AK et al.. “Acute paediatric kidney replacement therapies in Europe: demographic results from the EurAKId Registry.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 34586417 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  519. [519]

    Sever MS, Vanholder R, Luyckx V et al.. “Armed conflicts and kidney patients: a consensus statement from the Renal Disaster Relief Task Force of the ERA.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023). PMID: 35998320 ↗

    L5OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  520. [520]

    Yun D, Kim DK, Lee JP et al.. “Can sodium fluorescein cause contrast-induced nephropathy?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021). PMID: 31773157 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  521. [521]

    . “[Clinical practice guideline for renal replacement therapy in critically ill patients with acute kidney injury (2026 edition)].” Zhonghua yi xue za zhi (2026). PMID: 42203644 ↗

    L5GUIDELINECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  522. [522]

    Paulus AB, Gupta G, Gungor A et al.. “Outcomes of Kidney Transplants From Donors With Stage 3 Acute Kidney Injury Requiring Dialysis: A National Cohort Study.” Clinical transplantation (2026). PMID: 41954271 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  523. [523]

    Chen YC, Nordin MN, Krishna Moorthy PS et al.. “Incidence, risk factors and outcomes of postoperative acute kidney injury requiring dialysis after cardiac surgery: a retrospective study from the National Heart Institute of Malaysia.” Journal of cardiothoracic surgery (2026). PMID: 41935268 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  524. [524]

    Abdelazim AM, Alaaeldin B, Amer AM et al.. “Hemofilters versus hemodialyzers: impacts on cytokine removal during cardiopulmonary bypass in pediatric cardiac surgery: a randomized controlled trial.” Journal of cardiothoracic surgery (2026). PMID: 41975514 ↗

    L1RCTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  525. [525]

    Hinze C, Lovric S, Halloran PF et al.. “Epithelial cell states associated with kidney and allograft injury.” Nature reviews. Nephrology (2024). PMID: 38632381 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy, Prevention, Screening & Surveillance
  526. [526]

    Lu R, Kiernan MC, Murray A et al.. “Kidney-brain crosstalk in the acute and chronic setting.” Nature reviews. Nephrology (2015). PMID: 26281892 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment, Prognosis and Natural History, Special Populations & Pregnancy
  527. [527]

    Prowle JR, Bellomo R. “Continuous renal replacement therapy: recent advances and future research.” Nature reviews. Nephrology (2010). PMID: 20644583 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, History and Evolution of Treatment
  528. [528]

    Schrier RW. “Early intervention in acute kidney injury.” Nature reviews. Nephrology (2010). PMID: 20023689 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Prevention, Screening & Surveillance
  529. [529]

    Nadim MK, Forni LG, Mehta RL et al.. “COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.” Nature reviews. Nephrology (2020). PMID: 33060844 ↗

    L1REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  530. [530]

    Bertram JF, Goldstein SL, Pape L et al.. “Kidney disease in children: latest advances and remaining challenges.” Nature reviews. Nephrology (2016). PMID: 26831913 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  531. [531]

    McCulloch M, Luyckx VA, Cullis B et al.. “Challenges of access to kidney care for children in low-resource settings.” Nature reviews. Nephrology (2020). PMID: 33005036 ↗

    L5REVIEW_NARRATIVECited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  532. [532]

    Liu C, Alasfar S, Reese PP et al.. “Trends in the procurement and discard of kidneys from deceased donors with acute kidney injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021). PMID: 34897982 ↗

    L2OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Special Populations & Pregnancy
  533. [533]

    Kawamura M, Matsumura S, Abe T et al.. “A novel Si-based antioxidant agent attenuates antibody-mediated rejection in allogeneic rat kidney transplantation.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2025). PMID: 39848340 ↗

    L5OTHERCited in: Renal Replacement Therapy, Dialysis Access & Transplantation, Complications (Chronic Systemic Sequelae), Prognosis and Natural History
  534. [534]

    Ou Q, He D, Shi X et al.. “Citrate doubles CRRT filter lifespan: A real-world Chinese cohort study.” The International journal of artificial organs (2026). PMID: 41987744 ↗

    L2COHORTCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  535. [535]

    Rafique B, Arshad AR, Sabir S et al.. “N-acetylcysteine as Prophylaxis Against Contrast-Induced Nephropathy: A Meta-Analysis.” Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (2026). PMID: 42015439 ↗

    L1SR_OBSCited in: Renal Replacement Therapy, Dialysis Access & Transplantation
  536. [536]

    Jörres A, John S, Lewington A et al.. “A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guidelines on Acute Kidney Injury: part 2: renal replacement therapy.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2013). PMID: 24121762 ↗

    L1GUIDELINECited in: History and Evolution of Treatment
  537. [537]

    Ortiz A, Arici M, Goumenos DS et al.. “Randomized controlled trials in Europe: a call to action to protect national healthcare systems from the upcoming tsunami of kidney failure.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 41578941 ↗

    L5RCTCited in: History and Evolution of Treatment
  538. [538]

    Ascher SB, Katz R, Estrella MM et al.. “Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 40268226 ↗

    L2RCTCited in: History and Evolution of Treatment
  539. [539]

    Schetz M, Vanhorebeek I, Wouters PJ et al.. “Tight blood glucose control is renoprotective in critically ill patients.” Journal of the American Society of Nephrology : JASN (2008). PMID: 18235100 ↗

    L1RCTCited in: History and Evolution of Treatment
  540. [540]

    Garg AX, Badner N, Bagshaw SM et al.. “Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.” Journal of the American Society of Nephrology : JASN (2019). PMID: 31221679 ↗

    L1RCTCited in: History and Evolution of Treatment
  541. [541]

    Hingorani S, Schmicker RH, Brophy PD et al.. “Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates.” Clinical journal of the American Society of Nephrology : CJASN (2021). PMID: 34117080 ↗

    L2RCTCited in: History and Evolution of Treatment
  542. [542]

    Brown JR, Solomon R, Stabler ME et al.. “Team-Based Coaching Intervention to Improve Contrast-Associated Acute Kidney Injury: A Cluster-Randomized Trial.” Clinical journal of the American Society of Nephrology : CJASN (2023). PMID: 36787125 ↗

    L1RCTCited in: History and Evolution of Treatment, Prevention, Screening & Surveillance
  543. [543]

    Soomro QH, Anand ST, Weisbord SD et al.. “The Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 36008352 ↗

    L2RCTCited in: History and Evolution of Treatment, Prevention, Screening & Surveillance
  544. [544]

    Heerspink HJL, Furtado RHM, Berwanger O et al.. “Dapagliflozin and Kidney Outcomes in Hospitalized Patients with COVID-19 Infection: An Analysis of the DARE-19 Randomized Controlled Trial.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35483733 ↗

    L2RCTCited in: History and Evolution of Treatment
  545. [545]

    Thomson DJ, Price JM, Tyler M et al.. “Proton beam therapy for oropharyngeal cancer (TORPEdO): a phase 3, randomised controlled trial.” Lancet (London, England) (2026). PMID: 41875914 ↗

    L1RCTCited in: History and Evolution of Treatment, Prognosis and Natural History
  546. [546]

    Wong F, Boyer TD, Sanyal AJ et al.. “Reduction in acute kidney injury stage predicts survival in patients with type-1 hepatorenal syndrome.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2020). PMID: 30887050 ↗

    L2RCTCited in: History and Evolution of Treatment
  547. [547]

    Shapiro J, Ray JG, McArthur E et al.. “Risk of Acute Kidney Injury After Hypertensive Disorders of Pregnancy: A Population-Based Cohort Study.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34487795 ↗

    L2COHORTCited in: History and Evolution of Treatment
  548. [548]

    Markowitz GS, Perazella MA. “Acute phosphate nephropathy.” Kidney international (2009). PMID: 19675530 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  549. [549]

    Izzedine H, Perazella MA, Kuruvada KM et al.. “Cancer therapy and the kidney.” Kidney international (2026). PMID: 41866123 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  550. [550]

    Eknoyan G, Epstein M. “Hepatorenal syndrome: a historical appraisal of its origins and conceptual evolution.” Kidney international (2021). PMID: 33781792 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  551. [551]

    Lewington AJ, Cerdá J, Mehta RL. “Raising awareness of acute kidney injury: a global perspective of a silent killer.” Kidney international (2013). PMID: 23636171 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  552. [552]

    Yi TW, Laing C, Kretzler M et al.. “Digital health and artificial intelligence in kidney research: a report from the 2020 Kidney Disease Clinical Trialists (KDCT) meeting.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 34791422 ↗

    L5TRIAL_NONRANDOMCited in: History and Evolution of Treatment
  553. [553]

    Barsoum RS. “Parasitic kidney disease: milestones in the evolution of our knowledge.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2013). PMID: 23337800 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  554. [554]

    Malhotra R, Siew ED. “Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury.” Clinical journal of the American Society of Nephrology : CJASN (2016). PMID: 27827308 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  555. [555]

    Birkelo BC, Pannu N, Siew ED. “Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35292532 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  556. [556]

    Scherer JS, Holley JL. “The Role of Time-Limited Trials in Dialysis Decision Making in Critically Ill Patients.” Clinical journal of the American Society of Nephrology : CJASN (2015). PMID: 26450932 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  557. [557]

    Heher EC, Thier SO, Rennke H et al.. “Adverse renal and metabolic effects associated with oral sodium phosphate bowel preparation.” Clinical journal of the American Society of Nephrology : CJASN (2008). PMID: 18596115 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  558. [558]

    Mohan A, Herrmann SM. “Capmatinib-Induced Pseudo-Acute Kidney Injury: A Case Report.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34118303 ↗

    L4CASE_REPORTCited in: History and Evolution of Treatment, Prognosis and Natural History, Special Populations & Pregnancy
  559. [559]

    Shakoor MT, Birkenbach MP, Lynch M. “ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2021). PMID: 34280507 ↗

    L4CASE_REPORTCited in: History and Evolution of Treatment, Prevention, Screening & Surveillance
  560. [560]

    Heyman SN, Gorelik Y, Zorbavel D et al.. “Near-drowning: new perspectives for human hypoxic acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2020). PMID: 30768198 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  561. [561]

    Canaud G, Bonventre JV. “Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2014). PMID: 25016609 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  562. [562]

    Hoenig MP, Brooks CR, Hoorn EJ et al.. “Biology of the proximal tubule in body homeostasis and kidney disease.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2025). PMID: 39066502 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  563. [563]

    Ingelfinger JR, Kalantar-Zadeh K, Schaefer F. “Averting the legacy of kidney disease--focus on childhood.” Kidney international (2016). PMID: 26880442 ↗

    L5OTHERCited in: History and Evolution of Treatment
  564. [564]

    Cai A, Ye G, Placier S et al.. “Genetic inactivation of Semaphorin 3C protects mice from acute kidney injury.” Kidney international (2022). PMID: 35090878 ↗

    L5OTHERCited in: History and Evolution of Treatment
  565. [565]

    Casemayou A, Fournel A, Bagattin A et al.. “Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.” Journal of the American Society of Nephrology : JASN (2017). PMID: 28739648 ↗

    L5CASE_REPORTCited in: History and Evolution of Treatment
  566. [566]

    Kazancioğlu R. “Risk factors for chronic kidney disease: an update.” Kidney international supplements (2013). PMID: 25019021 ↗

    L5OTHERCited in: History and Evolution of Treatment
  567. [567]

    Hamano T, Nakano C, Obi Y et al.. “Fibroblast growth factor 23 and 25-hydroxyvitamin D levels are associated with estimated glomerular filtration rate decline.” Kidney international supplements (2013). PMID: 25019032 ↗

    L2OTHERCited in: History and Evolution of Treatment
  568. [568]

    Nakazawa D, Masuda S, Nishibata Y et al.. “Neutrophils and NETs in kidney disease.” Nature reviews. Nephrology (2025). PMID: 40102634 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  569. [569]

    Lam NN, Lentine KL, Levey AS et al.. “Long-term medical risks to the living kidney donor.” Nature reviews. Nephrology (2015). PMID: 25941060 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  570. [570]

    Haase M, Kellum JA, Ronco C. “Subclinical AKI--an emerging syndrome with important consequences.” Nature reviews. Nephrology (2012). PMID: 23007617 ↗

    L5REVIEW_NARRATIVECited in: History and Evolution of Treatment
  571. [571]

    Xiu X, Zheng PP, Li Y et al.. “A systematic review of semaglutide-associated kidney injury case reports.” Frontiers in medicine (2026). PMID: 42305970 ↗

    L4SR_OBSCited in: History and Evolution of Treatment
  572. [572]

    Santoriello D, Khairallah P, Bomback AS et al.. “Postmortem Kidney Pathology Findings in Patients with COVID-19.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32727719 ↗

    L4OTHERCited in: History and Evolution of Treatment
  573. [573]

    Yang B, Lan S, Dieudé M et al.. “Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury.” Journal of the American Society of Nephrology : JASN (2018). PMID: 29925521 ↗

    L5OTHERCited in: History and Evolution of Treatment
  574. [574]

    Salei N, Rambichler S, Salvermoser J et al.. “The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties.” Journal of the American Society of Nephrology : JASN (2020). PMID: 31932472 ↗

    L5OTHERCited in: History and Evolution of Treatment
  575. [575]

    Serttas MF, Uysal A, Deği̇rmenci̇ A et al.. “The impact of urinary catheterization on urinary tract infection and renal function in elderly patients undergoing hip fracture surgery: A prospective randomized controlled trial.” Injury (2026). PMID: 42296627 ↗

    L1RCTCited in: History and Evolution of Treatment
  576. [576]

    Rivero J, Merino-López M, Olmedo R et al.. “Association between Postmortem Kidney Biopsy Findings and Acute Kidney Injury from Patients with SARS-CoV-2 (COVID-19).” Clinical journal of the American Society of Nephrology : CJASN (2021). PMID: 33782033 ↗

    L4OTHERCited in: History and Evolution of Treatment
  577. [577]

    Deng YH, Liu Q, Luo XQ. “Masked hypertension and non-dipping blood pressure profiles in pediatric survivors of acute kidney injury: a systematic review and meta-analysis.” Journal of human hypertension (2026). PMID: 42420406 ↗

    L2SR_OBSCited in: History and Evolution of Treatment
  578. [578]

    Ning L, Chen M, Luo H et al.. “Factors associated with postoperative acute kidney injury in stanford type a aortic dissection in china: a systematic review and meta-analysis.” Journal of cardiothoracic surgery (2026). PMID: 42260504 ↗

    L2SR_OBSCited in: History and Evolution of Treatment
  579. [579]

    Blanchette PS, Reid J, Richard L et al.. “Practice patterns and outcomes in cancer patients developing immune checkpoint inhibitors-related AKI.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 41014247 ↗

    L2OTHERCited in: History and Evolution of Treatment
  580. [580]

    Kraft L, Oberacker T, Schwab A et al.. “Clinical course up to 20 years after hantavirus infection.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2026). PMID: 41070942 ↗

    L2OTHERCited in: History and Evolution of Treatment
  581. [581]

    Hamroun A, Frimat L, Laville M et al.. “New insights into acute-on-chronic kidney disease in nephrology patients: the CKD-REIN study.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 34473306 ↗

    L2OTHERCited in: History and Evolution of Treatment
  582. [582]

    Kaur R, Singh A. “Efficacy and Safety of GLP-1 Receptor Agonists on Combined Cardiovascular and Renal Outcomes in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis.” Diabetes, obesity & metabolism (2026). PMID: 42337824 ↗

    L1SR_OBSCited in: History and Evolution of Treatment
  583. [583]

    Yu K, King K, Husain SA et al.. “Kidney nonprocurement in solid organ donors in the United States.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020). PMID: 32342627 ↗

    L2OTHERCited in: History and Evolution of Treatment
  584. [584]

    Popma JJ, Deeb GM, Yakubov SJ et al.. “Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients.” The New England journal of medicine (2019). PMID: 30883053 ↗

    L1RCTCited in: Complications (Chronic Systemic Sequelae)
  585. [585]

    Leithead JA, Tariciotti L, Gunson B et al.. “Donation after cardiac death liver transplant recipients have an increased frequency of acute kidney injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2012). PMID: 22226302 ↗

    L2TRIAL_NONRANDOMCited in: Complications (Chronic Systemic Sequelae)
  586. [586]

    Privratsky JR, Ide S, Chen Y et al.. “A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury.” Kidney international (2022). PMID: 36334787 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  587. [587]

    Hato T, Dagher PC. “Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40601936 ↗

    L5REVIEW_NARRATIVECited in: Complications (Chronic Systemic Sequelae)
  588. [588]

    Creed HA, Kannan S, Tate BL et al.. “Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2024). PMID: 38506705 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  589. [589]

    Gerhardt LMS, Koppitch K, van Gestel J et al.. “Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2023). PMID: 36735940 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  590. [590]

    Hüsing AM, Wulfmeyer VC, Gaedcke S et al.. “Myeloid CCR2 Promotes Atherosclerosis after AKI.” Journal of the American Society of Nephrology : JASN (2022). PMID: 35537780 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  591. [591]

    Cosmai L, Porta C, Gallieni M et al.. “Onco-nephrology: a decalogue.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015). PMID: 26341467 ↗

    L5REVIEW_NARRATIVECited in: Complications (Chronic Systemic Sequelae)
  592. [592]

    Matei A, Tinică G, Bacușcă A et al.. “Changing Epidemiology, Healthcare-Associated Infections, and Outcomes in Infective Endocarditis: A Five-Year Retrospective Study from a Tertiary Cardiovascular Center.” Medicina (Kaunas, Lithuania) (2026). PMID: 42356041 ↗

    L4COHORTCited in: Complications (Chronic Systemic Sequelae)
  593. [593]

    Molema G, Zijlstra JG, van Meurs M et al.. “Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury.” Nature reviews. Nephrology (2021). PMID: 34667283 ↗

    L5REVIEW_NARRATIVECited in: Complications (Chronic Systemic Sequelae)
  594. [594]

    Shi L, Song Z, Li Y et al.. “MiR-20a-5p alleviates kidney ischemia/reperfusion injury by targeting ACSL4-dependent ferroptosis.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2023). PMID: 36695612 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  595. [595]

    Schütte-Nütgen K, Edeling M, Kentrup D et al.. “Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2022). PMID: 35801504 ↗

    L5OTHERCited in: Complications (Chronic Systemic Sequelae)
  596. [596]

    Zha Q, Xiong K, Wei M et al.. “Incidence and Risk Factors of Postoperative Acute Kidney Injury in Colorectal Cancer Patients With Metabolic Syndrome: A Retrospective Cohort Study.” Annali italiani di chirurgia (2026). PMID: 42304146 ↗

    L2COHORTCited in: Complications (Chronic Systemic Sequelae)
  597. [597]

    Lamontagne F, Masse MH, Menard J et al.. “Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.” The New England journal of medicine (2022). PMID: 35704292 ↗

    L1RCTCited in: Prognosis and Natural History
  598. [598]

    Perner A, Haase N, Guttormsen AB et al.. “Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.” The New England journal of medicine (2012). PMID: 22738085 ↗

    L1RCTCited in: Prognosis and Natural History
  599. [599]

    Palmer SC, Mavridis D, Navarese E et al.. “Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis.” Lancet (London, England) (2015). PMID: 26009228 ↗

    L1SR_OBSCited in: Prognosis and Natural History
  600. [600]

    Batista PG, Albino Dos Santos Silva RR, Malik M et al.. “Percutaneous Coronary Intervention Prior to Transcatheter Aortic Valve Implantation: A Bayesian Meta-Analysis of Randomized Controlled Trials.” The Canadian journal of cardiology (2026). PMID: 42385979 ↗

    L1SR_MA_RCTCited in: Prognosis and Natural History
  601. [601]

    Li Y, Hu C, Zhai P et al.. “Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury.” Kidney international (2023). PMID: 38163633 ↗

    L5OTHERCited in: Prognosis and Natural History
  602. [602]

    Rosenberg ME. “Cell-based therapies in kidney disease.” Kidney international supplements (2013). PMID: 25019020 ↗

    L5OTHERCited in: Prognosis and Natural History
  603. [603]

    Gelfand SL, Scherer JS, Koncicki HM. “Kidney Supportive Care: Core Curriculum 2020.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2020). PMID: 32173108 ↗

    L5REVIEW_NARRATIVECited in: Prognosis and Natural History
  604. [604]

    Chen L, Ye Z, Yang S et al.. “RNA-Binding Protein Lgals3 , Ferroptosis, and Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2025). PMID: 39928414 ↗

    L5OTHERCited in: Prognosis and Natural History
  605. [605]

    Sharfuddin AA, Sandoval RM, Berg DT et al.. “Soluble thrombomodulin protects ischemic kidneys.” Journal of the American Society of Nephrology : JASN (2009). PMID: 19176699 ↗

    L5OTHERCited in: Prognosis and Natural History, Prevention, Screening & Surveillance
  606. [606]

    Trindade-Correia S, Correia V, Delgado F et al.. “Engineered Neuromedin U Promotes Type 2 Innate Immunity and Renoprotection in Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2025). PMID: 40338728 ↗

    L5OTHERCited in: Prognosis and Natural History
  607. [607]

    Ortiz A, Husi H, Gonzalez-Lafuente L et al.. “Mitogen-Activated Protein Kinase 14 Promotes AKI.” Journal of the American Society of Nephrology : JASN (2016). PMID: 27620989 ↗

    L5OTHERCited in: Prognosis and Natural History
  608. [608]

    Gao Q, Lai X, Tian Y et al.. “Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study.” Frontiers in medicine (2026). PMID: 42292189 ↗

    L2COHORTCited in: Prognosis and Natural History
  609. [609]

    Larpnarongchai S, Maneenil G, Thatrimontrichai A et al.. “Clinical Factors Associated with Ventilator-Free Days in Newborns with Persistent Pulmonary Hypertension of the Newborn: A Retrospective Cohort Study in Thailand.” Journal of clinical medicine (2026). PMID: 42279237 ↗

    L2COHORTCited in: Prognosis and Natural History
  610. [610]

    Sevillano AM, Diaz M, Caravaca-Fontán F et al.. “IgA Nephropathy in Elderly Patients.” Clinical journal of the American Society of Nephrology : CJASN (2019). PMID: 31311818 ↗

    L2OTHERCited in: Prognosis and Natural History, Special Populations & Pregnancy
  611. [611]

    Kosugi T, Sato W. “Midkine and the kidney: health and diseases.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2011). PMID: 22167595 ↗

    L5REVIEW_NARRATIVECited in: Prognosis and Natural History
  612. [612]

    Ben Mahmoud N, Hamouda M, Ben Salem M et al.. “Risk factors of mortality in patients with acute kidney injury: Retrospective cohort study with longitudinal follow-up.” World journal of nephrology (2026). PMID: 42395687 ↗

    L2COHORTCited in: Prognosis and Natural History
  613. [613]

    Zhang Q, Liu Y, Ran B et al.. “Efficacy and optimal timing of sivelestat in critically ill patients with COVID-19: a multicenter retrospective cohort study.” BMC pulmonary medicine (2026). PMID: 42337706 ↗

    L2COHORTCited in: Prognosis and Natural History
  614. [614]

    Wang R, Ren Y, Song Y et al.. “Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury: a retrospective cohort study.” Journal of cardiothoracic surgery (2026). PMID: 42304487 ↗

    L2COHORTCited in: Prognosis and Natural History
  615. [615]

    Shoucair S, Khan J, Ahmed AS et al.. “Robotic recipient liver transplantation worldwide: a systematic review and meta-analysis of the first 93 patients, from feasibility to early outcomes.” EClinicalMedicine (2026). PMID: 42382137 ↗

    L4SR_OBSCited in: Prognosis and Natural History
  616. [616]

    Durey MA, Sinha A, Togarsimalemath SK et al.. “Anti-complement-factor H-associated glomerulopathies.” Nature reviews. Nephrology (2016). PMID: 27452363 ↗

    L5REVIEW_NARRATIVECited in: Prognosis and Natural History
  617. [617]

    O'Leary JG, Levitsky J, Wong F et al.. “Protecting the Kidney in Liver Transplant Candidates: Practice-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2016). PMID: 26990924 ↗

    L1REVIEW_NARRATIVECited in: Prognosis and Natural History
  618. [618]

    Jadlowiec CC, Heilman RL, Smith ML et al.. “Transplanting kidneys from donation after cardiac death donors with acute kidney injury.” American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2019). PMID: 31612611 ↗

    L2OTHERCited in: Prognosis and Natural History
  619. [619]

    Regusci A, Lava SAG, Milani GP et al.. “Tubulointerstitial nephritis and uveitis syndrome: a systematic review.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022). PMID: 33561271 ↗

    L4SR_OBSCited in: Special Populations & Pregnancy
  620. [620]

    Lee J, Lee J, Kim K et al.. “Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition.” Kidney international (2024). PMID: 38431216 ↗

    L2OTHERCited in: Special Populations & Pregnancy
  621. [621]

    Piccoli GB, Ahmed SB, Fakhouri F et al.. “Women and kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.” Kidney international (2025). PMID: 40439632 ↗

    L1OTHERCited in: Special Populations & Pregnancy
  622. [622]

    Joyce EL, Kane-Gill SL, Priyanka P et al.. “Piperacillin/Tazobactam and Antibiotic-Associated Acute Kidney Injury in Critically Ill Children.” Journal of the American Society of Nephrology : JASN (2019). PMID: 31501354 ↗

    L2OTHERCited in: Special Populations & Pregnancy
  623. [623]

    Yang Y, Lang XB, Zhang P et al.. “Remote ischemic preconditioning for prevention of acute kidney injury: a meta-analysis of randomized controlled trials.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2014). PMID: 24954246 ↗

    L1SR_MA_RCTCited in: Prevention, Screening & Surveillance
  624. [624]

    Zhou C, Gong J, Chen D et al.. “Levosimendan for Prevention of Acute Kidney Injury After Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2015). PMID: 26518388 ↗

    L1SR_MA_RCTCited in: Prevention, Screening & Surveillance
  625. [625]

    Brar SS, Hiremath S, Dangas G et al.. “Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.” Clinical journal of the American Society of Nephrology : CJASN (2009). PMID: 19713291 ↗

    L1SR_OBSCited in: Prevention, Screening & Surveillance
  626. [626]

    Liu Y, Guo W, Zhang J et al.. “Urinary interleukin 18 for detection of acute kidney injury: a meta-analysis.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2013). PMID: 23830182 ↗

    L1SR_OBSCited in: Prevention, Screening & Surveillance
  627. [627]

    Funahashi Y, Park SH, Hebert JF et al.. “Nanotherapeutic kidney cell-specific targeting to ameliorate acute kidney injury.” Kidney international (2024). PMID: 39067856 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  628. [628]

    Cuarental L, Ribagorda M, Ceballos MI et al.. “The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury.” Kidney international (2022). PMID: 36565807 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  629. [629]

    Li JSY, Robertson H, Trinh K et al.. “Tolerogenic dendritic cells protect against acute kidney injury.” Kidney international (2023). PMID: 37244471 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  630. [630]

    Diamantidis CJ, Zepel L, Smith VA et al.. “Epidemiology of Community-Acquired Acute Kidney Injury Among US Veterans.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2023). PMID: 36963745 ↗

    L3OTHERCited in: Prevention, Screening & Surveillance
  631. [631]

    Zhuo L, Zhang B, Huang Y et al.. “Association of Influenza Vaccination With Acute Kidney Injury: A Prospective Target Trial Emulation Study.” American journal of kidney diseases : the official journal of the National Kidney Foundation (2025). PMID: 41110628 ↗

    L2OTHERCited in: Prevention, Screening & Surveillance
  632. [632]

    Cheng L, Zhang B, Hu X et al.. “Diagnostic value of cystatin C in acute kidney injury among patients with sepsis: a systematic review and meta-analysis.” Frontiers in medicine (2026). PMID: 42359058 ↗

    L1SR_OBSCited in: Prevention, Screening & Surveillance
  633. [633]

    Antkowiak M, Domka J, Kasza R et al.. “Complications of controlled hypotension during functional endoscopic sinus surgery - a systematic review.” BMC anesthesiology (2026). PMID: 42286476 ↗

    L2SR_OBSCited in: Prevention, Screening & Surveillance
  634. [634]

    Robinson CH, Jeyakumar N, Luo B et al.. “Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2024). PMID: 39018120 ↗

    L3OTHERCited in: Prevention, Screening & Surveillance
  635. [635]

    de Caestecker M, Humphreys BD, Liu KD et al.. “Bridging Translation by Improving Preclinical Study Design in AKI.” Journal of the American Society of Nephrology : JASN (2015). PMID: 26538634 ↗

    L5REVIEW_NARRATIVECited in: Prevention, Screening & Surveillance
  636. [636]

    Li HF, Cheng CF, Liao WJ et al.. “ATF3-mediated epigenetic regulation protects against acute kidney injury.” Journal of the American Society of Nephrology : JASN (2010). PMID: 20360311 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  637. [637]

    Chen H, Wang L, Wang W et al.. “ELABELA and an ELABELA Fragment Protect against AKI.” Journal of the American Society of Nephrology : JASN (2017). PMID: 28583915 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  638. [638]

    Silva Barbosa AC, Zhou D, Xie Y et al.. “Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.” Journal of the American Society of Nephrology : JASN (2020). PMID: 32424001 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  639. [639]

    Perry HM, Huang L, Ye H et al.. “Endothelial Sphingosine 1‑Phosphate Receptor‑1 Mediates Protection and Recovery from Acute Kidney Injury.” Journal of the American Society of Nephrology : JASN (2016). PMID: 26961351 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  640. [640]

    Cashion W, Weisbord SD. “Radiographic Contrast Media and the Kidney.” Clinical journal of the American Society of Nephrology : CJASN (2022). PMID: 35777831 ↗

    L5OTHERCited in: Prevention, Screening & Surveillance
  641. [641]

    Rosner MH, Okusa MD. “Acute kidney injury associated with cardiac surgery.” Clinical journal of the American Society of Nephrology : CJASN (2005). PMID: 17699187 ↗

    L5REVIEW_NARRATIVECited in: Prevention, Screening & Surveillance
  642. [642]

    Keaney JJ, Hannon CM, Murray PT. “Contrast-induced acute kidney injury: how much contrast is safe?” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2013). PMID: 23413087 ↗

    L5REVIEW_NARRATIVECited in: Prevention, Screening & Surveillance
  643. [643]

    Morigi M, Benigni A. “Mesenchymal stem cells and kidney repair.” Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2012). PMID: 23258756 ↗

    L5REVIEW_NARRATIVECited in: Prevention, Screening & Surveillance
  644. [644]

    Bhat L, Pandey D, Bhatia K et al.. “Leveraging an Explainable Machine Learning Model for Early Identification of Acute Kidney Injury: A Retrospective Study.” The journal of applied laboratory medicine (2026). PMID: 42378106 ↗

    L3COHORTCited in: Prevention, Screening & Surveillance
  645. [645]

    Jha V, Parameswaran S. “Community-acquired acute kidney injury in tropical countries.” Nature reviews. Nephrology (2013). PMID: 23458924 ↗

    L5REVIEW_NARRATIVECited in: Prevention, Screening & Surveillance
  646. [646]

    Van Weydevelt E, Alrajhi Z, Vannier C et al.. “Two-year outcomes of fenestrated and branched stent grafts in patients ≤65 years: A bicenter retrospective study.” Journal of vascular surgery cases and innovative techniques (2026). PMID: 42255379 ↗

    L3COHORTCited in: Prevention, Screening & Surveillance
  647. [647]

    Bernhardt K, Collie S, Jacobs DWC et al.. “Analysis of adverse events following COVID-19 vaccination and infection: A retrospective, comparative cohort study using a claims database from Discovery Health, a managed care organisation in South Africa.” South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (2026). PMID: 42246858 ↗

    L3COHORTCited in: Prevention, Screening & Surveillance

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